{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:23:49Z","timestamp":1775791429447,"version":"3.50.1"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1023\/a:1022588326219","type":"journal-article","created":{"date-parts":[[2003,3,28]],"date-time":"2003-03-28T23:03:18Z","timestamp":1048892598000},"page":"276-280","source":"Crossref","is-referenced-by-count":43,"title":["Chromosomal Mosaicism in Cleavage-Stage Human Embryos and the Accuracy of Single-Cell Genetic Analysis"],"prefix":"10.1007","volume":"15","author":[{"given":"Hung-Chih","family":"Kuo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Mackie","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan H.","family":"Handyside","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"421535_CR1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/(SICI)1097-0223(199602)16:2<137::AID-PD824>3.0.CO;2-H","volume":"16","author":"A Ao","year":"1996","unstructured":"Ao A, Ray P, Harper JC, Lesko J, Handyside AH, Hughes MR, Winston RML: Clinical experience with preimplantation diagnosis of cystic fibrosis (F508). Prenat Diagn 1996;16:137-142","journal-title":"Prenat Diagn"},{"key":"421535_CR2","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1023\/A:1023008921386","volume":"15","author":"A Ao","year":"1998","unstructured":"Ao A, Wells D, Handyside AH, Winston RML, Delhanty JDA: Preimplantation diagnosis of familial adenomatous polyposis. J Assist Reprod Genet 1998;15:140-144","journal-title":"J Assist Reprod Genet"},{"key":"421535_CR3","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/hmg\/2.8.1183","volume":"2","author":"JD Delhanty","year":"1993","unstructured":"Delhanty JD, Griffin DK, Handyside AH, Harper J, Atkinson GH, Pieters MH, Winston RM: Detection of aneuploidy and chromosomal mosaicism in human embryos during preimplantation sex determination by fluorescent in situ hybridisation (FISH). Hum Mol Genet 1993;2:1183-1185","journal-title":"Hum Mol Genet"},{"key":"421535_CR4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s004390050443","volume":"99","author":"JD Delhanty","year":"1997","unstructured":"Delhanty JD, Harper JC, Ao A, Handyside AH, Winston RM: Multicolour FISH detects frequent chromosomal mosaicism and chaotic division in normal preimplantation embryos from fertile patients. Hum Genet 1997;99:755-760","journal-title":"Hum Genet"},{"key":"421535_CR5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0168-9525(97)01166-9","volume":"13","author":"AH Handyside","year":"1997","unstructured":"Handyside AH, Delhanty JD: Preimplantation genetic diagnosis: Strategies and surprises. Trends Genet 1997;13:270-275","journal-title":"Trends Genet"},{"key":"421535_CR6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJM199209243271301","volume":"327","author":"AH Handyside","year":"1992","unstructured":"Handyside AH, Lesko JG, Tarin JJ, Winston RM, Hughes MR: Birth of a normal girl after in vitro fertilization and preimplantation diagnostic testing for cystic fibrosis [see comments]. N Engl J Med 1992;327:905-909","journal-title":"N Engl J Med"},{"key":"421535_CR7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1530\/jrf.0.0980549","volume":"98","author":"K Hardy","year":"1993","unstructured":"Hardy K, Winston RM, Handyside AH: Binucleate blastomeres in preimplantation human embryos in vitro: Failure of cytokinesis during early cleavage. J Reprod Fertil 1993;98:549-558","journal-title":"J Reprod Fertil"},{"key":"421535_CR8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/oxfordjournals.humrep.a138577","volume":"9","author":"JC Harper","year":"1994","unstructured":"Harper JC, Coonen E, Ramaekers FC, Delhanty JD, Handyside AH, Winston RM, Hopman AH: Identification of the sex of human preimplantation embryos in two hours using an improved spreading method and fluorescent in-situ hybridization (FISH) using directly labelled probes. Hum Reprod 1994;9:721-724","journal-title":"Hum Reprod"},{"key":"421535_CR9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/molehr\/2.2.93","volume":"2","author":"A Jurisicova","year":"1996","unstructured":"Jurisicova A, Varmuza S, Casper RF: Programmed cell death and human embryo fragmentation. Mol Hum Reprod 1996;2:93-98","journal-title":"Mol Hum Reprod"},{"key":"421535_CR10","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/oxfordjournals.humrep.a019424","volume":"11","author":"I Kligman","year":"1996","unstructured":"Kligman I, Benadiva C, Alikani M, Munne S: The presence of multinucleated blastomeres in human embryos is correlated with chromosomal abnormalities. Hum Reprod 1996;11:1492-1498","journal-title":"Hum Reprod"},{"key":"421535_CR11","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/oxfordjournals.humrep.a138283","volume":"8","author":"J Liu","year":"1993","unstructured":"Liu J, Van den Abbeel E, Van Steirteghem A: The in-vitro and in-vivo developmental potential of frozen and non-frozen biopsied 8-cell mouse embryos. Hum Reprod 1993;8:1481-1486","journal-title":"Hum Reprod"},{"key":"421535_CR12","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/oxfordjournals.humrep.a138003","volume":"8","author":"AL Muggleton Harris","year":"1993","unstructured":"Muggleton Harris AL, Glazier AM, Pickering SJ: Biopsy of the human blastocyst and polymerase chain reaction (PCR) amplification of the beta-globin gene and a dinucleotide repeat motif from 2\u20136 trophectoderm cells. Hum Reprod 1993;8:2197-2205","journal-title":"Hum Reprod"},{"key":"421535_CR13","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1093\/oxfordjournals.humrep.a138001","volume":"8","author":"S Munn\u00e9","year":"1993","unstructured":"Munn\u00e9 S, Lee A, Rosenwaks Z, Grifo J, Cohen J: Diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum Reprod 1993;8:2185-2191","journal-title":"Hum Reprod"},{"key":"421535_CR14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1095\/biolreprod51.3.373","volume":"51","author":"S Munn\u00e9","year":"1994","unstructured":"Munn\u00e9 S, Weier HU, Grifo J, Cohe J: Chromosome mosaicism in human embryos. Biol Reprod 1994;51:373-379","journal-title":"Biol Reprod"},{"key":"421535_CR15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1159\/000134497","volume":"75","author":"S Munn\u00e9","year":"1996","unstructured":"Munn\u00e9 S, Weier HU: Simultaneous enumeration of chromosomes 13, 18, 21, X, and Y in interphase cells for preimplantation genetic diagnosis of aneuploidy. Cytogenet Cell Genet 1996;75:263-270","journal-title":"Cytogenet Cell Genet"},{"key":"421535_CR16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/oxfordjournals.humrep.a137253","volume":"6","author":"NJ Winston","year":"1991","unstructured":"Winston NJ, Braude PR, Pickering SJ, George MA, Cant A, Currie J, Johnson MH: (1991). The incidence of abnormal morphology and nucleocytoplasmic ratios in 2-, 3-and 5-day human preembryos. Hum Reprod 1991;6:17-24","journal-title":"Hum Reprod"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1022588326219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1022588326219\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1022588326219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:57:30Z","timestamp":1749121050000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1022588326219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["421535"],"URL":"https:\/\/doi.org\/10.1023\/a:1022588326219","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,5]]}}}