{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:57:22Z","timestamp":1790902642708,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,3,1]],"date-time":"1998-03-01T00:00:00Z","timestamp":888710400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Immunol"],"published-print":{"date-parts":[[1998,3]]},"DOI":"10.1023\/a:1023246800353","type":"journal-article","created":{"date-parts":[[2003,6,6]],"date-time":"2003-06-06T17:39:54Z","timestamp":1054921194000},"page":"124-131","source":"Crossref","is-referenced-by-count":34,"title":["Induction of HIV-1 Replication by Type 1-Like Cytokines, Interleukin (IL)-12 and IL-15: Effect on Viral Transcriptional Activation, Cellular Proliferation, and Endogenous Cytokine Production"],"prefix":"10.1007","volume":"18","author":[{"given":"Lena","family":"Al-Harthi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Roebuck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Landay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"421442_CR1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0006-291X(89)80025-7","volume":"165","author":"N Kobayashi","year":"1989","unstructured":"Kobayashi N, Hamamoto Y, Koyanagi Y, et al.: Effects of interleukin-1 on the augmentation of human immunodeficiency virus gene expression. Biochem Biophys Res Commun 165:715\u2013721, 1989","journal-title":"Biochem Biophys Res Commun"},{"key":"421442_CR2","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1073\/pnas.86.7.2336","volume":"86","author":"L Osborn","year":"1989","unstructured":"Osborn L, Kunkel S, Nabel GJ: Tumor necrosis factor \u03b1 and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor \u03baB. Proc Natl Acad Sci USA 86:2336\u20132340, 1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"421442_CR3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1084\/jem.172.1.151","volume":"172","author":"G Poli","year":"1990","unstructured":"Poli G, Bressler P, Kinter AL, et al.: Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis alpha by transcriptional and post-transcriptional mechanisms. J Exp Med 172:151\u2013158, 1990","journal-title":"J Exp Med"},{"key":"421442_CR4","first-page":"108","volume":"9","author":"G Poli","year":"1989","unstructured":"Poli G, Kinter AL, Fauci AS: Interleukin 1 induces expression of human immunodeficiency virus alone and in synergy with interleukin 6 in chronically infected U1 cells: Inhibition of inductive effect by interleukin 1 receptor antagonist. Proc Natl Acad Sci USA 9:108\u2013112, 1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"421442_CR5","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1089\/aid.1990.6.1045","volume":"6","author":"HE Gendelman","year":"1990","unstructured":"Gendelman HE, Baca L, Turpin JA, Kalter DC, et al.: Restriction of HIV replication in infected T cells and monocytes by interferonalpha. AIDS Res Hum Retrovirus 6:1045\u20131049, 1990","journal-title":"AIDS Res Hum Retrovirus"},{"key":"421442_CR6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/viro.1993.1110","volume":"1993","author":"PR Meylan","year":"1993","unstructured":"Meylan PR, Guatelli JC, Munis JR, Richman DD, Kornbluth RS: Mechanisms for the inhibition of interferons-alpha,-beta, and-gamma in primary human macrophages. Virology 1993:138\u2013148, 1993","journal-title":"Virology"},{"key":"421442_CR7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/384529a0","volume":"389","author":"AS Fauci","year":"1996","unstructured":"Fauci AS: Host factors and the pathogenesis of HIV-induced disease. Nature 389:529\u2013534, 1996","journal-title":"Nature"},{"key":"421442_CR8","first-page":"329","volume":"78","author":"D Hober","year":"1989","unstructured":"Hober D, Haque A, Waltre P, et al.: Production of tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) in patients with AIDS: Enhanced level of TNF-alpha is related to higher cytotoxic activity. Clin Exp Immunol 78:329\u2013333, 1989","journal-title":"Clin Exp Immunol"},{"key":"421442_CR9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1093\/infdis\/166.4.731","volume":"166","author":"L Trentin","year":"1992","unstructured":"Trentin L, Garbsa S, Zambello R, et al.: Spontaneous production of IL-6 by alveolar macrophages from human immunodeficiency virus type 1 infected patients. J Infect Dis 166:731\u2013737, 1992","journal-title":"J Infect Dis"},{"key":"421442_CR10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00042560-199509050-00005","volume":"9","author":"V Navikas","year":"1995","unstructured":"Navikas V, Link J, Persson C, et al.: Increased mRNA expression of IL-6, IL-1, TNF-alpha, perforin in blood mononuclear cells in human immunodeficiency virus infection. J Acquir Immune Defic Syndr Hum Retrovirol 9:484\u2013489, 1995","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"421442_CR11","unstructured":"Lederman MM, Connick E, Landay A, et al.: Partial immune reconstitution after 12 weeks of HAART (AZT, 3TC, Ritonavir) preliminary results of ACTG 315. 4th Conference on Retroviruses and Opportunistic Infections. Washington, DC, Jan 1997, abstr LB13"},{"key":"421442_CR12","unstructured":"Cameron DW, Heath-Chiozzi M, Kravick S, Mills R, Pathoff A, Henry D: Prolongation of life and prevention of AIDS complications in advanced HIV immunodeficiency with ritonavir: Update. Int Conf AIDS 1998, abstr Mo.B.411"},{"key":"421442_CR13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nm0597-533","volume":"3","author":"M Conners","year":"1997","unstructured":"Conners M, Kovacs JA, Krevat S, et al.: HIV infection induces changes in CD4+ T-cell phenotypes and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nat Med 3:533\u2013540, 1997","journal-title":"Nat Med"},{"issue":"SupplA","key":"421442_CR14","first-page":"S149","volume":"11","author":"AD Kelleher","year":"1997","unstructured":"Kelleher AD, Al-Harthi L, Landay A: Immunological effects of antiretroviral and immune therapies for HIV. AIDS 11(Suppl A):S149\u2013S155, 1997","journal-title":"AIDS"},{"key":"421442_CR15","first-page":"512","volume":"3","author":"HC Lane","year":"1984","unstructured":"Lane HC, Siegel JP, Rook AH, et al.: Use of interleukin-2 in patients with acquired immunodeficiency syndrome. J Biol Response Modif 3:512\u2013516, 1984","journal-title":"J Biol Response Modif"},{"key":"421442_CR16","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/aid.1987.3.115","volume":"3","author":"P Volberding","year":"1987","unstructured":"Volberding P, Moody DJ, Beardslee, et al.: Therapy of acquired immune deficiency syndrome with recombinant Interleukin-2. AIDS Res Hum Retrovirus 3:115\u2013124, 1987","journal-title":"AIDS Res Hum Retrovirus"},{"key":"421442_CR17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00126334-199101000-00002","volume":"4","author":"DH Schwartz","year":"1991","unstructured":"Schwartz DH, Skowron G, Merigan TC: Safety and effects of interleukin-2 plus zidoviduine in asymptomatic individuals infected with human immunodeficiency virus. J Acquir Immune Defic Syndr 4:11\u201323, 1991","journal-title":"J Acquir Immune Defic Syndr"},{"key":"421442_CR18","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM199610313351803","volume":"335","author":"JA Kovacs","year":"1996","unstructured":"Kovacs JA, Vogel S, Albert JM, et al.: Controlled trial of interleukin-2 infusions in patients with the human immunodeficiency virus. N Engl J Med 335:1350\u20131356, 1996","journal-title":"N Engl J Med"},{"key":"421442_CR19","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1126\/science.7903123","volume":"262","author":"M Clerici","year":"1993","unstructured":"Clerici M, Lucey DR, Berzofsky JA, et al.: Restoration of HIV-1 specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721\u20131724, 1993","journal-title":"Science"},{"key":"421442_CR20","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/infdis\/173.5.1085","volume":"173","author":"AL Landay","year":"1996","unstructured":"Landay AL, Clerici M, Hashemi F, et al.: In vitro T cell immune function in HIV+ individuals: Effects of IL-12 and anti-IL-10. J Infect Dis 173:1085\u20131091, 1996","journal-title":"J Infect Dis"},{"key":"421442_CR21","doi-asserted-by":"crossref","first-page":"5978","DOI":"10.4049\/jimmunol.158.12.5978","volume":"158","author":"J Chechimi","year":"1997","unstructured":"Chechimi J, Marshall JD, Salvucci O, et al.: IL-15 enhances immune function during HIV infection. J Immunol 158:5978\u20135987, 1997","journal-title":"J Immunol"},{"key":"421442_CR22","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1128\/cdli.3.5.547-553.1996","volume":"3","author":"M Bayard-McNeeley","year":"1996","unstructured":"Bayard-McNeeley M, Doo H, He S, Hafner A, Johnson WD, Ho JL: Differential effects of interleukin-12, interleukin-15, and interleukin-2 on human immunodeficiency virus type 1 replication in vitro. Clin Diagn Lab Immunol 3:547\u2013553, 1996","journal-title":"Clin Diagn Lab Immunol"},{"key":"421442_CR23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/infdis\/173.3.559","volume":"173","author":"RE Akridge","year":"1996","unstructured":"Akridge RE, Reed SG: Interleukin-12 decreases human immunodeficiency virus type 1 replication in human macrophage cultures reconstituted with autologous peripheral blood mononuclear cells. J Infect Dis 173:559\u2013564, 1996","journal-title":"J Infect Dis"},{"key":"421442_CR24","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1172\/JCI118831","volume":"98","author":"AH Patki","year":"1996","unstructured":"Patki AH, Quinones-Mateu ME, Dorzaio D, Yen-Lieberman B, Boom WH, Thomas EK, Lederman MM: Activation of antigen-induced lymphocyte proliferation by interleukin-15 without the mitogenic effect of interleukin-2 that may induce human immunodeficiency virus-1 expression. J Clin Invest 98:616\u2013621, 1996","journal-title":"J Clin Invest"},{"key":"421442_CR25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1128\/cdli.4.1.43-48.1997","volume":"4","author":"DR Lucey","year":"1997","unstructured":"Lucey DR, Pinto LA, Bethke FR, Rusnak J, Melcher GP, Hashemi FN, Landay AL, et al.: In vitro immunologic and virologic effects of interleukin 15 on peripheral blood mononuclear cells from normal donors and human immunodeficiency virus type-1 infected patients. Clin Diagn Lab Immunol 4:43\u201348, 1997","journal-title":"Clin Diagn Lab Immunol"},{"key":"421442_CR26","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4049\/jimmunol.156.2.841","volume":"156","author":"A Finnegan","year":"1996","unstructured":"Finnegan A, Roebuck KA, Nakai BE, Gu DS, Rabbi MF, Song S, Landay AL: IL-10 cooperates with TNF-alpha to activate HIV-1 from latently and acutely infected cells of monocyte\/macrophage lineage. J Immunol 156:841\u2013851, 1996","journal-title":"J Immunol"},{"issue":"6","key":"421442_CR27","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.4049\/jimmunol.156.6.2324","volume":"156","author":"MD Smithgall","year":"1996","unstructured":"Smithgall MD, Wong JG, Critchett KE, Haffar OK: IL-7 up-regulates HIV-1 replication in naturally infected peripheral blood mononuclear cells. J Immunol 156(6):2324\u20132330, 1996","journal-title":"J Immunol"},{"issue":"10","key":"421442_CR28","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.4049\/jimmunol.154.10.5093","volume":"154","author":"PT Mehrotra","year":"1995","unstructured":"Mehrotra PT, Grant AJ, Siegel JP: Synergistic effects of IL-7 and IL-12 on human T cell activation. J Immunol 154(10):5093\u20135102, 1995","journal-title":"J Immunol"},{"issue":"3","key":"421442_CR29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1084\/jem.176.3.739","volume":"176","author":"P Biswas","year":"1992","unstructured":"Biswas P, Poli G, Kinter AL, et al.: Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbal myristate. J Exp Med 176(3):739\u2013750, 1992","journal-title":"J Exp Med"},{"key":"421442_CR30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1172\/JCI110981","volume":"72","author":"AH Rook","year":"1983","unstructured":"Rook AH, Masur H, Lane HC, et al.: Interleukin-2 enhances the depressed natural killer and cytomeglovirus-specific cytotoxic activity of lymphocytes from patients with the acquired immunodeficiency syndrome. J Clin Invest 72:398\u2013403, 1983","journal-title":"J Clin Invest"},{"key":"421442_CR31","doi-asserted-by":"crossref","first-page":"10985","DOI":"10.1073\/pnas.92.24.10985","volume":"92","author":"AL Kinter","year":"1995","unstructured":"Kinter AL, Bende SM, Hardy EC, Jacobson RJ, Fauci AS: Interleukin 2 induces CD8+ T cell mediated suppression in CD4+ T cells and this effect overrides its ability to stimulate virus expression. Proc Natl Acad Sci USA 92:10985\u201310989, 1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"421442_CR32","doi-asserted-by":"crossref","first-page":"11135","DOI":"10.1073\/pnas.92.24.11135","volume":"92","author":"F Barker","year":"1995","unstructured":"Barker F, Mackowicz CF, Levy JA: Effects of TH1 and TH2 cytokines on CD8+ cell response against human immunodeficiency virus: implications for long-term survival. Proc Natl Acad Sci USA 92:11135\u201311149, 1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"421442_CR33","doi-asserted-by":"crossref","first-page":"118111","DOI":"10.1073\/pnas.91.25.11811","volume":"91","author":"M Clerici","year":"1994","unstructured":"Clerici M, Sarin A, Coffman RL, Wynn TA, Blatt SP, Hendrix CW, et al.: Type 1\/type 2 cytokine modulation of T-cell programmed cell death as a model for human immunodeficiency virus pathogenesis. Proc Natl Acad Sci USA 91:118111\u201318115, 1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"421442_CR34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/infdis\/167.2.291","volume":"167","author":"H Teppler","year":"1993","unstructured":"Teppler H, Kaplan G, Smith K, et al.: Efficacy of low doses of the polyethylene glycol derivative of interleukin-2 in modulating the immune responses of patients with human immunodeficiency virus type 1 infection. J Infect Dis 167:291\u2013298, 1993","journal-title":"J Infect Dis"},{"key":"421442_CR35","doi-asserted-by":"crossref","first-page":"10405","DOI":"10.1073\/pnas.93.19.10405","volume":"93","author":"EL Jacobson","year":"1996","unstructured":"Jacobson EL, Pillaro F, Smith A: Rational interleukin-2 therapy for HIV positive individuals: Daily low doses enhance immune function without cytotoxicity. Proc Natl Acad Sci USA 93:10405\u201310410, 1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"421442_CR36","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJM199503023320904","volume":"332","author":"J Kovacs","year":"1995","unstructured":"Kovacs J, Baseler M, Dewar RJ, et al.: Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection: A preliminary study. N Engl J Med 332:567\u2013575, 1995","journal-title":"N Engl J Med"},{"key":"421442_CR37","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1086\/513971","volume":"175","author":"RT Davey","year":"1997","unstructured":"Davey RT, Chaitt DG, Piscitelli SC, et al.: Subcutaneous administration of interleukin-2 in human immunodeficiency virus type-1 infected patients. J Infect Dis 175:781\u2013789, 1997","journal-title":"J Infect Dis"},{"key":"421442_CR38","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1126\/science.8178155","volume":"264","author":"KH Grabstein","year":"1994","unstructured":"Grabstein KH, Eisenman J, Shanebeck K, et al.: Cloning of a T cell growth factor that interacts with the \u03b2 chain of the interleukin-2 receptor. Science 264:965\u2013968, 1994","journal-title":"Science"},{"key":"421442_CR39","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1084\/jem.182.4.1067","volume":"182","author":"RA Seder","year":"1995","unstructured":"Seder RA, Grabstein KH, Berzofsky JA, McDyer JF: Cytokine interaction in human immunodeficiency virus-infected individuals: Roles of interleukin IL-2, IL-12, and IL-15. J Exp Med 182:1067\u20131078, 1995","journal-title":"J Exp Med"},{"key":"421442_CR40","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1084\/jem.182.6.1759","volume":"182","author":"J Estaquire","year":"1995","unstructured":"Estaquire J, Idziorek T, Zou W, et al.: T helper type 1\/T helper type 2 cytokines and T cell death: Effect of interleukin-12 on activation-induced CD95 (fas\/apo-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons. J Exp Med 182:1759\u20131769, 1995","journal-title":"J Exp Med"},{"key":"421442_CR41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/cimm.1995.1003","volume":"161","author":"M Radrizzini","year":"1995","unstructured":"Radrizzini M, Accornero P, Amidei A, Aiello A, Delia D, Kurrle D, Colombo MP: IL-12 inhibits apoptosis induced in human TH1 clone by gp120\/CD4 cross-linking and CD3\/TCR activation or by IL-2 deprivation. Cell Immunol 161:14\u201321, 1995","journal-title":"Cell Immunol"},{"key":"421442_CR42","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1084\/jem.175.3.789","volume":"175","author":"J Chehimi","year":"1992","unstructured":"Chehimi J, Starr SE, Frank I, et al.: Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from healthy donors and human immunodeficiency virus-infected patients. J Exp Med 175:787\u2013796, 1992","journal-title":"J Exp Med"},{"key":"421442_CR43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/infdis\/174.3.483","volume":"174","author":"P Uherova","year":"1996","unstructured":"Uherova P, Connick E, McWhinnery S, Schlichtemer, Schooley RT: In vitro effect of interleukin-12 on antigen-specific lymphocyte proliferative response from persons infected with human immunodeficiency virus type 1. J Infect Dis 174:483\u2013489, 1996","journal-title":"J Infect Dis"},{"key":"421442_CR44","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/infdis\/174.5.1105","volume":"174","author":"S Kohl","year":"1996","unstructured":"Kohl S, Sigaroudinia M, Charlebois ED, Jacobson MA: Interleukin-12 administered in vivo decreases human NK cell cytotoxicity and antibody-dependent cellular cytotoxicity to human immunodeficiency virus-infected cells. J Infect Dis 174:1105\u20131108, 1996","journal-title":"J Infect Dis"},{"key":"421442_CR45","unstructured":"Jacobson MA, Hardy D, Connick E, Anderson R, Debruin M: Phase I trial recombinant human interleukin-12 in HIV infected subjects. 3rd Conference on Retroviruses and Opportunistic Infections, Washington, DC, January 1996, abstr 309"},{"key":"421442_CR46","unstructured":"McLeod G, Hammer S: Effects of interleukin (IL)-12 on HIV-1 replication in vitro. First National Conference on Human Retroviruses and Related Infections. Washington, DC, 1993, abstr p 118"},{"key":"421442_CR47","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/cimm.1994.1032","volume":"153","author":"CE Mackewicz","year":"1994","unstructured":"Mackewicz CE, Ortega H, Levy JA: Effects of cytokines on HIV replication in CD4+ lymphocytes: Lack of identity with the CD8+ cell antiviral factor. Cell Immunol 153:329\u2013336, 1994","journal-title":"Cell Immunol"},{"key":"421442_CR48","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1182\/blood.V85.8.2114.bloodjournal8582114","volume":"85","author":"A Foli","year":"1995","unstructured":"Foli A, Saville MW, Baseler MW, Yarchoan R: Effects of the TH1 and TH2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication. Blood 85:2114\u20132123, 1995","journal-title":"Blood"}],"container-title":["Journal of Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1023246800353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1023246800353\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1023246800353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:32:10Z","timestamp":1751031130000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1023246800353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,3]]}},"alternative-id":["421442"],"URL":"https:\/\/doi.org\/10.1023\/a:1023246800353","relation":{},"ISSN":["0271-9142","1573-2592"],"issn-type":[{"value":"0271-9142","type":"print"},{"value":"1573-2592","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,3]]}}}