{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:09:27Z","timestamp":1774123767757,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Virus Genes"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1023\/a:1023487413912","type":"journal-article","created":{"date-parts":[[2003,6,6]],"date-time":"2003-06-06T13:42:07Z","timestamp":1054906927000},"page":"165-173","source":"Crossref","is-referenced-by-count":6,"title":["Epstein\u2013Barr Virus DNA is Detected in Peripheral Blood Mononuclear Cells of EBV-seronegative Infants with Infectious Mononucleosis-like Symptoms"],"prefix":"10.1007","volume":"26","author":[{"given":"Kazufumi","family":"Ikuta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Saiga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Sairenji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"5121627_CR1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/infdis\/121.3.303","volume":"121","author":"G. Henle","year":"1970","unstructured":"Henle G. and Henle W., Observations on childhood: Infections with the Epstein-Barr virus. J Infect Dis 121, 303-310, 1970.","journal-title":"J Infect Dis"},{"key":"5121627_CR2","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJM197606172942501","volume":"294","author":"J.C. Niederman","year":"1976","unstructured":"Niederman J.C., Miller G., Pearson H.A., Pagano J.S., and Dowaliby J.M., Infectious mononucleosis; Epstein-Barr virus shedding in saliva and the oropharynx. N Eng J Med 294, 1355-1359, 1976.","journal-title":"N Eng J Med"},{"key":"5121627_CR3","unstructured":"University Health Physicians, PHLS Laboratories, Infectious mononucleosis and its relationship to EB virus antibody. Br Med J 643-646, 1971."},{"key":"5121627_CR4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1073\/pnas.59.1.94","volume":"59","author":"G. Henle","year":"1968","unstructured":"Henle G., Henle W. and Diehl V., Relation of Burkitt's tumor-associated herpes-type virus to infectious mononucleosis. Proc Natl Acad Sci USA 59, 94-101, 1968.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5121627_CR5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/978-3-642-67236-1_13","volume-title":"The Epstein-Barr Virus","author":"G. Henle","year":"1979","unstructured":"Henle G. and Henle W., The virus as the etiologic agent of infectious mononucleosis. The Epstein-Barr Virus, Springer Verlag, New York, 1979, pp. 297-319."},{"key":"5121627_CR6","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0046-8177(74)80006-7","volume":"5","author":"W. Henle","year":"1974","unstructured":"Henle W., Henle G., and Horwitz C.A., The Epstein-Barr virus specific diagnostic tests in infectious mononucleosis. Human Pathol 5, 551-565, 1974.","journal-title":"Human Pathol"},{"key":"5121627_CR7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1286-4579(00)00277-X","volume":"2","author":"K. Ikuta","year":"2000","unstructured":"Ikuta K., Satoh Y., Hoshikawa Y., and Sairenji T., Detection of Epstein-Barr virus in salivas and throat washings in healthy adults and children. Microb Infect 2, 115-120, 2000.","journal-title":"Microb Infect"},{"key":"5121627_CR8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-642-67236-1_4","volume-title":"The Epstein-Barr Virus","author":"W. Henle","year":"1979","unstructured":"Henle W. and Henle G., Seroepidemiology of the virus. The Epstein-Barr Virus Springer Verlag, New York, 1979, pp. 61-78."},{"key":"5121627_CR9","first-page":"65","volume":"7","author":"Y. Hinuma","year":"1969","unstructured":"Hinuma Y., Biology of a herpes-type virus associated with Burkitt lymphoma cell lines. Gann Monograph 7, 65-76, 1969.","journal-title":"Gann Monograph"},{"key":"5121627_CR10","first-page":"1","volume":"21","author":"A. Boyum","year":"1968","unstructured":"Boyum A., Separation of leukocytes from blood and bone marrow. Scand J Clin Lab Invest 21, 1-109, 1968.","journal-title":"Scand J Clin Lab Invest"},{"key":"5121627_CR11","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ijc.2910110302","volume":"11","author":"B.M. Reedman","year":"1973","unstructured":"Reedman B.M. and Klein G., Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines. Int J Cancer 11, 499-520, 1973.","journal-title":"Int J Cancer"},{"key":"5121627_CR12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.1349-7006.1990.tb02561.x","volume":"81","author":"H. Uhara","year":"1990","unstructured":"Uhara H., Sato Y., Mukai K., Akao I., Matsuno Y., Furuya S., Hoshikawa T., Shimosato Y., and Saida T., Detection of Epstein-Barr virus DNA in Reed-Sternberg cells of Hodgkin's disease using the polymerase chain reaction and in situ hybridization. Jpn J Cancer Res 81, 272-278, 1990.","journal-title":"Jpn J Cancer Res"},{"key":"5121627_CR13","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1128\/JCM.36.11.3423-3425.1998","volume":"36","author":"Y. Satoh","year":"1998","unstructured":"Satoh Y., Takasaka N., Hoshikawa Y., Osaki M., Ohfuji S., Itoh H., Kaibara N., Kurata T., and Sairenji T., Pretreatment with restriction enzyme or bovine serum albumin for effective PCR amplification of Epstein-Barr virus DNA extracted from paraffin-embedded gastric tissue. J Clin Microbiol 36, 3423-3425, 1998.","journal-title":"J Clin Microbiol"},{"key":"5121627_CR14","first-page":"1248","volume":"173","author":"A. Gradilone","year":"1996","unstructured":"Gradilone A., Vercillo R., Napolitano M., Cardinali G., Gazzaniga P., Silvestri I., Gandini O., Tomao S., and Agliano A.M., Prevalence of human papillomavirus, cytomegalovirus, and Epstein-Barr virus in the cervix of healthy women. J Med Virol 173, 1248-1251, 1996.","journal-title":"J Med Virol"},{"key":"5121627_CR15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/bjc.1996.412","volume":"74","author":"M. Sugiura","year":"1996","unstructured":"Sugiura M., Imai S., Tokunaga M., Koizumi S., Uchizawa M., Okamoto K., and Osato T., Transcriptional analysis of Epstein-Barr virus gene expression in EBV-positive gastric carcinoma: Unique viral latency in the tumor cells. Br J Cancer 74, 625-631, 1996.","journal-title":"Br J Cancer"},{"key":"5121627_CR16","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1128\/jvi.66.6.3715-3724.1992","volume":"66","author":"L. Qu","year":"1992","unstructured":"Qu L. and Rowe D.T., Epstein-Barr virus latent gene expression in uncultured peripheral blood lymphocytes. J Virol 66, 3715-3724, 1992.","journal-title":"J Virol"},{"key":"5121627_CR17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/viro.1999.9748","volume":"258","author":"X. Gao","year":"1998","unstructured":"Gao X., Tajima M., and Sairenji T., Nitric oxide down-regulates Epstein-Barr virus reactivation in epithelial cell lines. Virology 258, 375-381, 1998.","journal-title":"Virology"},{"key":"5121627_CR18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-3083.1998.00406.x","volume":"48","author":"M. Hurme","year":"1998","unstructured":"Hurme M. and Helminen M., Polymorphism of the IL-1 gene complex in Epstein-Barr virus seronegative and seropositive adult blood donors. Scand J Immunol 48, 219-222, 1998.","journal-title":"Scand J Immunol"},{"key":"5121627_CR19","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.1073\/pnas.81.23.7632","volume":"81","author":"T. Dambaugh","year":"1984","unstructured":"Dambaugh T., Hennessy K., Chamnankit L., and Kieff E., U2 region of Epstein-Barr virus DNA may encode Epstein-Barr nuclear antigen 2. Proc Natl Acad Sci 81, 7632-7636, 1984.","journal-title":"Proc Natl Acad Sci"},{"key":"5121627_CR20","doi-asserted-by":"crossref","first-page":"7374","DOI":"10.1128\/jvi.68.11.7374-7385.1994","volume":"68","author":"R.J. Tierney","year":"1994","unstructured":"Tierney R.J., Steven N., Young L.S., and Rickinson A.B., Epstein-Barr virus latency in blood mononuclear cells: Analysis of viral gene transcription during primary infection and in the carrier state. J Virol 68, 7374-7385, 1994.","journal-title":"J Virol"},{"key":"5121627_CR21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S1386-6532(01)00149-4","volume":"21","author":"K.H. Chan","year":"2001","unstructured":"Chan K.H., Tam J.S.L., Peiris J.S.M., Seto W.H., and Ng M.H., Epstein-Barr virus (EBV) infection in infancy. J Clin Virol 21, 57-62, 2001.","journal-title":"J Clin Virol"},{"key":"5121627_CR22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0092-8674(95)90513-8","volume":"80","author":"E.M. Miyashita","year":"1995","unstructured":"Miyashita E.M., Yang B., Lam K.M., Crawford D.H., and Thorley-Lawson D.A., A novel form of Epstein-Barr virus latency in normal B cells in vivo. Cell 80, 593-601, 1995.","journal-title":"Cell"},{"key":"5121627_CR23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1073\/pnas.70.1.190","volume":"70","author":"G. Miller","year":"1973","unstructured":"Miller G. and Lipman M., Release of infectious Epstein-Barr virus by transformed marmoset leukocytes. Proc Natl Acad Sci USA 70, 190-194, 1973.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5121627_CR24","doi-asserted-by":"crossref","first-page":"909","DOI":"10.4049\/jimmunol.168.2.909","volume":"168","author":"B. Savoldo","year":"2002","unstructured":"Savoldo B., Cubbage M.L., Durett A.G., Goss J., Huls M.H., Liu Z., Teresita L., Gee A.P., Ling P.D., Brenner M.K., Heslop H.E., and Rooney C.M., Generation of EBV-specific CD4+ cytotoxic T cells from virus naive individuals. J Immunol 168, 909-918, 2002.","journal-title":"J Immunol"},{"key":"5121627_CR25","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0008-8749(84)90032-7","volume":"87","author":"A.B. Rickinson","year":"1984","unstructured":"Rickinson A.B., Rowe M., Hart I., Yao Q.Y., Henderson L.E., Rabin H., and Epstein M.A., T cell-mediated regression of 'spontaneous' and of Epstein-Barr virus-induced B cell transformation in vivo: Studies with cyclosporine A. Cell Immunol 87, 646-655, 1984.","journal-title":"Cell Immunol"},{"key":"5121627_CR26","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1182\/blood.V98.6.1882","volume":"98","author":"Y. Kasahara","year":"2001","unstructured":"Kasahara Y., Yachie A., Takei K., Kanegane C., Okada K., Ohta K., Seki H., Igarashi N., Maruhashi K., Katayama K., Katoh E., Terao G., Sakiyama Y., and Koizumi S., Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Blood 98, 1882-1888, 2001.","journal-title":"Blood"},{"key":"5121627_CR27","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0140-6736(89)90829-5","volume":"8666","author":"J.W. Sixbey","year":"1989","unstructured":"Sixbey J.W., Shirley P., Chesney P.J., Buntin D.M., and Resnick L., Detection of a second widespread strain of Epstein-Barr virus. Lancet 8666, 761-765, 1989.","journal-title":"Lancet"},{"key":"5121627_CR28","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1006\/viro.1994.1422","volume":"202","author":"A. Apolloni","year":"1994","unstructured":"Apolloni A. and Sculley T.B., Detection of A-type and B-type Epstein-Barr virus in throat washings and lymphocytes. Virology 202, 978-981, 1994.","journal-title":"Virology"},{"key":"5121627_CR29","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1093\/infdis\/173.5.1248","volume":"173","author":"W.J. Jabs","year":"1996","unstructured":"Jabs W.J., Wagner H.J., Neustock P., Kluter H., and Kirchner H., Immunologic properties of Epstein-Barr virus-seronegative adults. J Infect Dis 173, 1248-1251, 1996.","journal-title":"J Infect Dis"}],"container-title":["Virus Genes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1023487413912.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1023487413912\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1023487413912.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:28:51Z","timestamp":1754904531000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1023487413912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["5121627"],"URL":"https:\/\/doi.org\/10.1023\/a:1023487413912","relation":{},"ISSN":["0920-8569","1572-994X"],"issn-type":[{"value":"0920-8569","type":"print"},{"value":"1572-994X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3]]}}}