{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:17:05Z","timestamp":1787001425985,"version":"build-2736575974"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Behav Genet"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1023\/a:1023498508987","type":"journal-article","created":{"date-parts":[[2003,6,6]],"date-time":"2003-06-06T13:42:07Z","timestamp":1054906927000},"page":"301-310","source":"Crossref","is-referenced-by-count":43,"title":["The Behavioral Profile of Severe Mental Retardation in a Genetic Mouse Model of Phenylketonuria"],"prefix":"10.1007","volume":"33","author":[{"given":"Simona","family":"Cabib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Pascucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentino","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Puglisi-Allegra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"5","key":"463872_CR1","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1651-2227.1998.tb01505.x","volume":"87","author":"G. L. Arnold","year":"1998","unstructured":"Arnold, G. L., Kramer, B. M., Kirby, R. S., Plumeau, P. B., Blakely, E. M., Sanger Cregan, L. S., and Davidson, P. W. (1998). Factors affecting cognitive, motor, behavioral and executive functioning in children with phenylketonuria. Acta Paediatr. 87(5): 565-570.","journal-title":"Acta Paediatr."},{"issue":"1\u20132","key":"463872_CR2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(01)00291-1","volume":"125","author":"C. Belzung","year":"2001","unstructured":"Belzung, C., and Griebel, G. (2001). Measuring normal and pathological anxiety-like behaviour in mice: A review. Behav. Brain. Res. 125(1\u20132): 141-149.","journal-title":"Behav. Brain. Res."},{"key":"463872_CR3","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1523\/JNEUROSCI.21-09-03228.2001","volume":"21","author":"H. W. Broening","year":"2001","unstructured":"Broening, H. W., Morford, L. L., Inman-Wood, S. L., Fukumura, M., and Vorhees, C. V. (2001). 3,4-methylenedioxymethamphetamine (ecstasy)-induced learning and memory impairments depend on the age of exposure during early development. J. Neurosci. 21: 3228-3235.","journal-title":"J. Neurosci."},{"issue":"1","key":"463872_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/08990229509063138","volume":"12","author":"G. E. Carvell","year":"1995","unstructured":"Carvell, G. E., and Simons, D. J. (1995). Task-and subject-related differences in sensorimotor behavior during active touch. Somatosens. Mot. Res. 12(1): 1-9.","journal-title":"Somatosens. Mot. Res."},{"key":"463872_CR5","doi-asserted-by":"crossref","first-page":"8853","DOI":"10.1523\/JNEUROSCI.20-23-08853.2000","volume":"20","author":"R. E. Clark","year":"2000","unstructured":"Clark, R. E., Zola, M. S., and Squire, L. R. (2000). Impaired recognition memory in rats after damage to the hippocampus. J. Neurosci. 20: 8853-8860.","journal-title":"J. Neurosci."},{"key":"463872_CR6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0003-9861(60)90504-X","volume":"91","author":"D. L. Coleman","year":"1960","unstructured":"Coleman, D. L. (1960). Phenylalanine hydroxylase activity in dilute and nondilute strains of mice. Arch. Biochem. Biophys. 91: 300-306.","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"463872_CR7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/1166208","volume":"62","author":"A. Diamond","year":"1997","unstructured":"Diamond, A., Prevor, M. B., Callender, G., and Druin, D. P. (1997). Prefrontal cortex cognitive deficits in children treated early and continuously for PKU. Monogr. Soc. Res. Child. Dev. 62(4): 1-208.","journal-title":"Monogr. Soc. Res. Child. Dev."},{"key":"463872_CR8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0166-4328(98)00079-5","volume":"99","author":"S. L. Dix","year":"1999","unstructured":"Dix, S. L., and Aggleton, J. P. (1999). Extending the spontaneous preference test of recognition: Evidence of object-location and object-context recognition. Behav. Brain Res. 99: 191-200.","journal-title":"Behav. Brain Res."},{"issue":"7","key":"463872_CR9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1097\/00005072-199607000-00005","volume":"55","author":"C. A. Dyer","year":"1996","unstructured":"Dyer, C. A., Kendler, A., Philibotte, T., Gardiner, P., Cruz, J., and Levy, H. L. (1996). Evidence for central nervous system glial cell plasticity in phenylketonuria. J. Neuropathol. Exp. Neurol. 55(7): 795-814.","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"463872_CR10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0306-4522(00)00292-X","volume":"100","author":"C. Dobkin","year":"2000","unstructured":"Dobkin, C., Rabe, A., Dumas, R., El Idrissi, A., Haubenstock, H., and Brown, W. T. (2000). Fmr1 knockout mouse has a distinctive strainspecific learning impairment. Neuroscience 100(2): 423-9.","journal-title":"Neuroscience"},{"issue":"4\u20135","key":"463872_CR11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S0031-9384(01)00602-3","volume":"74","author":"M. Fletcher","year":"2001","unstructured":"Fletcher, M., and Wilson, D. A. (2001). Ontogeny of odor discrimination: A method to assess novel odor discrimination in neonatal rats. Physiol. Behav. 74(4\u20135): 589-593.","journal-title":"Physiol. Behav."},{"issue":"2","key":"463872_CR12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0166-4328(97)00144-7","volume":"95","author":"R. Gerlai","year":"1998","unstructured":"Gerlai, R. (1998). Contextual learning and cue association in fear conditioning in mice: A strain comparison and a lesion study. Behav. Brain. Res. 95(2): 191-203.","journal-title":"Behav. Brain. Res."},{"key":"463872_CR13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF01799701","volume":"9","author":"F. Guttler","year":"1986","unstructured":"Guttler, F., and Lou, H. (1986). Dietary problems of phenylketonuria: Effect on CNS transmitters and their possible role in behaviour and neuropsychological function. J. Inherit. Metab. Dis. 9: 169-177.","journal-title":"J. Inherit. Metab. Dis."},{"key":"463872_CR14","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1073\/pnas.87.5.1965","volume":"87","author":"J. D. McDonald","year":"1990","unstructured":"McDonald, J. D., Bode, V. C., Dove, W. F., and Shedlovsky, A. (1990). Pahhph-5: A mouse mutant deficient in phenylalanine hydroxylase. Proc. Natl. Acad. Sci. USA 87: 1965-1967.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"463872_CR15","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/geno.1996.4508","volume":"39","author":"J. D. McDonald","year":"1997","unstructured":"McDonald, J. D., and Charlton, C. K. (1997). Characterization of mutations at the mouse phenylalanine hydroxylase locus. Genomics 39(3): 402-405.","journal-title":"Genomics"},{"key":"463872_CR16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0006-8993(72)90653-1","volume":"47","author":"C. M. McKean","year":"1972","unstructured":"McKean, C. M. (1972). The effects of high phenilalanine concentrations on serotonin and catecholamine metabolism in the human brain. Brain Res. 47: 469-476.","journal-title":"Brain Res."},{"issue":"3","key":"463872_CR17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1901\/jeab.2000.73-305","volume":"73","author":"S. M. Mihalick","year":"2000","unstructured":"Mihalick, S. M., Langlois, J. C., Krienke, J. D., and Dube, W. V. (2000). An olfactory discrimination procedure for mice. J. Exp. Anal. Behav. 73(3): 305-318.","journal-title":"J. Exp. Anal. Behav."},{"key":"463872_CR18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0166-4328(01)00367-9","volume":"127","author":"D. G. Mumby","year":"2001","unstructured":"Mumby, D. G. (2001). Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats. Behav. Brain Res. 127: 159-181.","journal-title":"Behav. Brain Res."},{"issue":"4","key":"463872_CR19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0301-0082(97)00036-1","volume":"53","author":"J. Myslivecek","year":"1997","unstructured":"Myslivecek, J. (1997). Inhibitory learning and memory in newborn rats. Prog. Neurobiol. 53(4): 399-430.","journal-title":"Prog. Neurobiol."},{"issue":"1","key":"463872_CR20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/hipo.10007","volume":"12","author":"E. Passino","year":"2002","unstructured":"Passino, E., Middei, S., Restivo, L., Bertaina-Anglade, V., and Ammassari-Teule, M. (2002). Genetic approach to variability of memory systems: Analysis of place vs. response learning and fos-related expression in hippocampal and striatal areas of C57BL\/6 and DBA\/2 mice. Hippocampus 12(1): 63-75.","journal-title":"Hippocampus"},{"issue":"6","key":"463872_CR21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/00019052-199812000-00012","volume":"11","author":"J. Pietz","year":"1998","unstructured":"Pietz, J. (1998). Neurological aspects of adult phenylketonuria. Curr. Opin. Neurol. 11(6): 679-688.","journal-title":"Curr. Opin. Neurol."},{"key":"463872_CR22","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1037\/0735-7044.103.5.1009","volume":"103","author":"B. Poucet","year":"1989","unstructured":"Poucet, B. (1989). Object exploration, habituation, and response to spatial change in rats following septal or medial frontal cortical damage. Behav. Neurosci. 103: 1009-1016.","journal-title":"Behav. Neurosci."},{"issue":"26","key":"463872_CR23","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1097\/00001756-200004270-00042","volume":"11","author":"S. Puglisi-Allegra","year":"2000","unstructured":"Puglisi-Allegra, S., Cabib, S., Pascucci, T., Ventura, R., Cal\u00ec, F., and Romano, V. (2000). Dramatic brain aminergic deficit in a genetic mouse model of phenylketonuria. Neuroreport 11(26): 1361-1364.","journal-title":"Neuroreport"},{"issue":"2","key":"463872_CR24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/1098-2302(200009)37:2<109::AID-DEV6>3.0.CO;2-D","volume":"37","author":"L. Ricceri","year":"2000","unstructured":"Ricceri, L., Colozza, C., and Calamandrei, G. (2000). Ontogeny of spatial discrimination in mice: A longitudinal analysis in the modified openfield with objects. Dev. Psychobiol. 37(2): 109-118.","journal-title":"Dev. Psychobiol."},{"issue":"1","key":"463872_CR25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-4328(05)80175-5","volume":"45","author":"C. Rossi-Arnaud","year":"1991","unstructured":"Rossi-Arnaud, C., Fagioli, S., and Ammassari-Teule, M. (1991). Spatial learning in two inbred strains of mice: Genotype-dependent effect of amygdaloid and hippocampal lesions. Behav. Brain. Res. 45(1): 9-16.","journal-title":"Behav. Brain. Res."},{"key":"463872_CR26","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1037\/0735-7044.111.5.976","volume":"111","author":"P. Roullet","year":"1997","unstructured":"Roullet, P., Mele, A., and Ammassari-Teule, M. (1997). Ibotenic acid lesions of the nucleus accumbens improve detection of spatial novelty in poor spatial learner mice. Behav. Neurosci. 111: 976-984.","journal-title":"Behav. Neurosci."},{"issue":"7","key":"463872_CR27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0168-9525(99)01761-8","volume":"15","author":"C. R. Scriver","year":"1999","unstructured":"Scriver, C. R., and Waters, P. J. (1999). Monogenic traits are not simple: Lessons from phenylketonuria. Trends Genet. 15(7): 267-272.","journal-title":"Trends Genet."},{"key":"463872_CR28","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/genetics\/134.4.1205","volume":"134","author":"A. Shedlovsky","year":"1993","unstructured":"Shedlovsky, A., McDonald, J. D., Symula, D., and Dove, W. F. (1993). Mouse models of human phenylketonuria. Genetics 134: 1205-1210.","journal-title":"Genetics"},{"key":"463872_CR29","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1471-4159.1993.tb05823.x","volume":"60","author":"N. Shimada","year":"1993","unstructured":"Shimada, N., Graf, R., Rosner, G., and Heiss, W. D. (1993) Ischemiainduced accumulation of extracellular amino acids in cerebral cortex, white matter, and cerebrospinal fluid. J. Neurochem. 60: 66-71.","journal-title":"J. Neurochem."},{"issue":"20","key":"463872_CR30","doi-asserted-by":"crossref","first-page":"11014","DOI":"10.1073\/pnas.97.20.11014","volume":"97","author":"C. B. Smith","year":"2000","unstructured":"Smith, C. B., and Kang, J. (2000). Cerebral protein synthesis in a genetic mouse model of phenylketonuria. Proc. Natl. Acad. Sci. USA. 97(20): 11014-11019.","journal-title":"Proc. Natl. Acad. Sci. USA."},{"issue":"2","key":"463872_CR31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1037\/0735-7044.107.2.254","volume":"107","author":"R. M. Sullivan","year":"1993","unstructured":"Sullivan, R. M., and Wilson, D. A. (1993). Role of the amygdala complex in early olfactory associative learning. Behav. Neurosci. 107(2): 254-63.","journal-title":"Behav. Neurosci."},{"issue":"1\u20132","key":"463872_CR32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0166-4328(01)00384-9","volume":"131","author":"D. G. Wallace","year":"2002","unstructured":"Wallace, D. G., Gorny, B., and Whishaw, I. Q. (2002). Rats can track odors, other rats, and themselves: Implications for the study of spatial behavior. Behav Brain Res. 131(1\u20132): 185-192.","journal-title":"Behav Brain Res."},{"key":"463872_CR33","first-page":"79","volume":"564","author":"P. M. Whitaker-Azmitia","year":"2001","unstructured":"Whitaker-Azmitia, P. M. (2001). Serotonin and brain development: Role in human developmental diseases. Brain Res. Bull. 564: 79-85.","journal-title":"Brain Res. Bull."},{"issue":"1","key":"463872_CR34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S135561770102001X","volume":"8","author":"D. A. White","year":"2002","unstructured":"White, D. A., Nortz, M. J., Mandernach, T., Huntington, K., and Steiner, R. D. (2002). Age-related working memory impairments in children with prefrontal dysfunction associated with phenylketonuria. J. Int. Neuropsychol. Soc. 8(1): 1-11.","journal-title":"J. Int. Neuropsychol. Soc."},{"issue":"14","key":"463872_CR35","doi-asserted-by":"crossref","first-page":"6175","DOI":"10.1523\/JNEUROSCI.19-14-06175.1999","volume":"19","author":"L. Zagreda","year":"1999","unstructured":"Zagreda, L., Goodman, J., Druin, D. P., McDonald, D., and Diamond, A. (1999). Cognitive deficits in a genetic mouse model of the most common biochemical cause of human mental retardation. J. Neurosci. 19(14): 6175-6182.","journal-title":"J. Neurosci."}],"container-title":["Behavior Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1023498508987.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1023498508987\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1023498508987.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T03:49:59Z","timestamp":1748058599000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1023498508987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["463872"],"URL":"https:\/\/doi.org\/10.1023\/a:1023498508987","relation":{},"ISSN":["0001-8244","1573-3297"],"issn-type":[{"value":"0001-8244","type":"print"},{"value":"1573-3297","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}