{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:21:40Z","timestamp":1767651700118,"version":"3.41.2"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurocytol"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1023\/a:1023993405851","type":"journal-article","created":{"date-parts":[[2003,6,9]],"date-time":"2003-06-09T16:05:44Z","timestamp":1055174744000},"page":"121-129","source":"Crossref","is-referenced-by-count":16,"title":["Apolipoprotein D in the Niemann-Pick type C disease mouse brain: An ultrastructural immunocytochemical analysis"],"prefix":"10.1007","volume":"31","author":[{"given":"Wei-Yi","family":"Ong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Yong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shutish C.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"5123160_CR1","doi-asserted-by":"crossref","first-page":"17805","DOI":"10.1016\/S0021-9258(18)38235-8","volume":"265","author":"J. K. Boyles","year":"1990","unstructured":"Boyles, J. K., Notterpek, L. M. & Anderson, L. J. (1990a) Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve. Identification of apolipoprotein D, apolipoprotein A-IV, apolipoprotein E, and apolipoprotein A-I. Journal of Biological Chemistry\n265, 17805\u201317815.","journal-title":"Journal of Biological Chemistry"},{"key":"5123160_CR2","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1016\/S0022-2275(20)42112-1","volume":"31","author":"J. K. Boyles","year":"1990","unstructured":"Boyles, J. K., Notterpek, L. M., Wardell, M. R. & Rall, S. C. Jr (1990b) Identification, characterization, and tissue distribution of apolipoprotein D in the rat. Journal of Lipid Research\n31, 2243\u20132256.","journal-title":"Journal of Lipid Research"},{"key":"5123160_CR3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1126\/science.277.5323.228","volume":"277","author":"E. D. Carstea","year":"1997","unstructured":"Carstea, E. D., Morris, J. A., Coleman, K. G., Loftus, S. K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M. A., Pavan, W. J., Krizman, D. B., Nagle, J., Polymeropoulos, M. H., Sturley, S. L., Ioannou, Y. A., Higgins, M. E., Comly, M., Cooney, A., Brown, A., Kaneski, C. R., Blanchette-Mackie, E. J., Dwyer, N. K., Neufeld, E. B., Chang, T. Y., Liscum, L. & Tagle, D. A. (1997) Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis. Science\n277, 228\u2013231.","journal-title":"Science"},{"key":"5123160_CR4","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.1074\/jbc.273.13.7691","volume":"273","author":"F. Dandoy-Dron","year":"1998","unstructured":"Dandoy-Dron, F., Guillo, F., Benboudjema, L., Deslys, J. P., Lasmezas, C., Dormont, D., Tovey, M. G. & Dron, M. (1998) Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Journal of Biological Chemistry\n273, 7691\u20137697.","journal-title":"Journal of Biological Chemistry"},{"key":"5123160_CR5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/dna.1987.6.199","volume":"6","author":"D. T. Drayna","year":"1987","unstructured":"Drayna, D. T., Mclean, J. W., Wion, K. L., Trent, J. M., Drabkin, H. A. & Lawn, R. G. (1987) Human apolipoprotein D gene: Gene sequence, chromosome localization and homology to alpha 2u-globulin superfamily. DNA\n6, 199\u2013204.","journal-title":"DNA"},{"key":"5123160_CR6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3180001","volume":"318","author":"D. R. Flower","year":"1996","unstructured":"Flower, D. R. (1996) The lipocalin protein family: Structure and function. Biochemistry Journal\n318, 1\u201314.","journal-title":"Biochemistry Journal"},{"key":"5123160_CR7","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1046\/j.1471-4159.1999.0731615.x","volume":"73","author":"G. Franz","year":"1999","unstructured":"Franz, G., Reindl, M., Patel, S. C., Beer, R., Unterrichter, I., Berger, T., Schmutzhard, E., Poewe, W. & Kampfl, A. (1999) Increased expression of apolipoprotein D following experimental traumatic brain injury. Journal of Neurochemistry\n73, 1615\u20131625.","journal-title":"Journal of Neurochemistry"},{"key":"5123160_CR8","first-page":"2085","volume":"62","author":"D. H. Gutmann","year":"2002","unstructured":"Gutmann, D. H., Hedrick, N. M., Li, J., Nagarajan, R., Perry, A. & Watson, M. A. (2002) Comparative gene expression profile analysis of neurofibromatosis 1\u2014associated and sporadic pilocytic astrocytomas. Cancer Research\n62, 2085\u20132091.","journal-title":"Cancer Research"},{"key":"5123160_CR9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1012797623620","volume":"30","author":"C. Y. Hu","year":"2001","unstructured":"Hu, C. Y., Ong, W. Y., Sundaram, R. K., Chan, C. & Patel, S. C. (2001) Immunocytochemical localization of apolipoprotein D in oigodendrocyte precursor-Like cells, perivascular cells, and pericytes in the human cerebral cortex. Journal of Neurocytology\n30, 209\u2013218.","journal-title":"Journal of Neurocytology"},{"key":"5123160_CR10","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/jnen\/61.3.275","volume":"61","author":"S. Hunter","year":"2002","unstructured":"Hunter, S., Young, A., Olson, J., Brat, D. J., Bowers, G., Wilcox, J. N., Jaye, D., Mendrinos, S. & Neish, A. (2002) Differential expression between pilocytic and anaplastic astrocytomas: Identification of apolipoprotein D as a marker for low grade, non-infiltrating primary CNS neoplasms. Journal of Neuropathology and Experimental Neurology\n61, 275\u2013281.","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"key":"5123160_CR11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1095\/biolreprod54.4.847","volume":"54","author":"C. Kirchhoff","year":"1996","unstructured":"Kirchhoff, C., Osterhoff, C. & Young, L. (1996) Molecular cloning and characterization of HE1, a major secretory protein of the human epididymis. Biology of Reproduction\n54, 847\u2013856.","journal-title":"Biology of Reproduction"},{"key":"5123160_CR12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0039-128X(88)90135-3","volume":"52","author":"O. A. Lea","year":"1988","unstructured":"Lea, O. A. (1988) Binding properties of progesteronebinding cyst protein, PBCP. Steroids\n52, 337\u2013338.","journal-title":"Steroids"},{"key":"5123160_CR13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1126\/science.277.5323.232","volume":"277","author":"S. K. Loftus","year":"1997","unstructured":"Loftus, S. K., Morris, J. A., Carstea, E. D., Gu, J. Z., Cummings, C., Brown, A., Ellison, J., Ohno, K., Rosenfeld, M. A., Tagle, D. A., Pentchev, P. G. & Pavan, W. J. (1997) Murine model of Niemann-Pick C Disease: Mutation in a cholesterol homeostasis gene. Science\n277, 232\u2013235.","journal-title":"Science"},{"key":"5123160_CR14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-5793(95)00484-Q","volume":"366","author":"J. H. Morais-Cabral","year":"1995","unstructured":"Morais-Cabral, J. H., Atkins, G. L., Sanchez, L. M., Lopez-Boado, Y. S., Lopez-Otin, C. & Sawyer, L. (1995) Arachidonic acid binds to apolipoprotein D: Implications for the protein's function. FEBS Letters\n366, 53\u201356.","journal-title":"FEBS Letters"},{"key":"5123160_CR15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.901390102","volume":"139","author":"S. Mori","year":"1970","unstructured":"Mori, S. & Leblond, C. P. (1970) Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats. Journal of Comparative Neurology\n139, 1\u201328.","journal-title":"Journal of Comparative Neurology"},{"key":"5123160_CR16","first-page":"140","volume":"108","author":"M. D. Morris","year":"1982","unstructured":"Morris, M. D., Bhuvaneswaran, C., Shio, H. & Fowler, S. (1982) Lysosome Lipid Storage Disorder in NCTR-BALB\/C mice: I. Description of the disease and genetics. American Journal of Pathology\n108, 140\u2013149.","journal-title":"American Journal of Pathology"},{"key":"5123160_CR17","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1126\/science.290.5500.2298","volume":"290","author":"S. Naureckiene","year":"2001","unstructured":"Naureckiene, S., Sleat, D. E., Lackland, H., Fensom, A., Vanier, M. T., Wattiaux, R., Jadot, M. & Lobel, P. (2001) Identification of HE1 as the second gene of Niemann-Pick C Disease. Science\n290, 2298\u20132301.","journal-title":"Science"},{"key":"5123160_CR18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(98)00639-9","volume":"254","author":"A. Navarro","year":"1998","unstructured":"Navarro, A., Tolivia, J., Astudillo, A. & del Valle, E. (1998) Pattern of apolipoprotein D immunoreactivity in human brain. Neuroscience Letters\n254, 17\u201320.","journal-title":"Neuroscience Letters"},{"key":"5123160_CR19","doi-asserted-by":"crossref","first-page":"9627","DOI":"10.1074\/jbc.274.14.9627","volume":"274","author":"E. B. Neufeld","year":"1999","unstructured":"Neufeld, E. B., Wastney, M., Patel, S., Suresh, S., Cooney, A. M., Dwyer, N. K., Roff, C. F., Ohno, K., Morris, J. A., Carstea, E. D., Incardona, J. P., Strauss, J. F. 3rd, Vanier, M. T., Patterson, M. C., Brady, R. O., Pentchev, P. G. & Blanchette-Mackie, E. J. (1999) The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. Journal of Biological Chemistry\n274, 9627\u20139635.","journal-title":"Journal of Biological Chemistry"},{"key":"5123160_CR20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S1388-1981(99)00070-0","volume":"1438","author":"N. Okamura","year":"1999","unstructured":"Okamura, N., Kiuchi, S., Tamba, M., Kashima, T., Hiramoto, S., Baba, T., Dacheux, F., Dacheux, J. L., Sugita, Y. & Jin, Y. Z. (1999) A ApoD in NP-C mice 129 porcine homolog of the major secretory protein of human epididymis, HE1, specifically binds cholesterol. Biochimica et Biophysica Acta\n1438, 377\u2013387.","journal-title":"Biochimica et Biophysica Acta"},{"key":"5123160_CR21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s002210100870","volume":"141","author":"W. Y. Ong","year":"2001","unstructured":"Ong, W. Y., Kumar, U., Switzer, R. C., Sidhu, A., Suresh, G., Hu, C. Y. & Patel, S. C. (2001) Neurodegeneration in Niemann-Pick Type C disease mice. Experimental Brain Research\n141, 218\u2013231.","journal-title":"Experimental Brain Research"},{"key":"5123160_CR22","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0306-4522(98)00507-7","volume":"90","author":"W. Y. Ong","year":"1999","unstructured":"Ong, W. Y., Lau, C. P., Leong, S. K., Kumar, U., Suresh, S. & Patel, S. C. (1999) Apolipoprotein D gene expression in the rat brain and light and electron microscopic immunocytochemistry of apolipoprotein D expression in the cerebellum of neonatal, immature and adult rats. Neuroscience\n90, 913\u2013922.","journal-title":"Neuroscience"},{"key":"5123160_CR23","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/protein\/10.6.621","volume":"10","author":"R. C. Patel","year":"1997","unstructured":"Patel, R. C., Lange, D., Mcconathy, W. J., Patel, Y. C. & Patel, S. C. (1997) Probing the structure of the ligand binding cavity of lipocalins by fluorescence spectroscopy. Protein Engineering\n10, 621\u2013625.","journal-title":"Protein Engineering"},{"key":"5123160_CR24","first-page":"197","volume":"2","author":"M. C. Peitsch","year":"1990","unstructured":"Peitsch, M. C. & Boguski, M. S. (1990) Is apolipoprotein D a mammalian bilin-binding protein? New Biologist\n2, 197\u2013206.","journal-title":"New Biologist"},{"key":"5123160_CR25","doi-asserted-by":"crossref","first-page":"5784","DOI":"10.1016\/S0021-9258(18)91082-3","volume":"259","author":"P. G. Pentchev","year":"1984","unstructured":"Pentchev, P. G., Boothe, A. D., Kruth, H. S., Weintroub, H., Stivers, J. & Brady, R. O. (1984) A genetic storage disorder in BALB\/C mice with a metabolic block in esterification of exogenous cholesterol. Journal of Biological Chemistry\n259, 5784\u20135791.","journal-title":"Journal of Biological Chemistry"},{"key":"5123160_CR26","volume-title":"Neurons and their Supporting Cells","author":"A. Peters","year":"1991","unstructured":"Peters, A., Palay, S. L. & Webster H. de F. (1991) The fine structure of the nervous system. Neurons and their Supporting Cells. Third edition. New York, Oxford: Oxford University Press.","edition":"Third edition"},{"key":"5123160_CR27","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0022-2275(20)41899-1","volume":"32","author":"P. R. Provost","year":"1991","unstructured":"Provost, P. R., Villeneuve, L., Weech, P. K., Milne, R. W., Marcel, Y. L. & Rassart, E. (1991) Localization of the major sites of rabbit apolipoprotein D gene transcription by in situ hybridization. Journal of Lipid Research\n32, 1959\u20131970.","journal-title":"Journal of Lipid Research"},{"key":"5123160_CR28","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/S0022-2275(20)42270-9","volume":"31","author":"P. R. Provost","year":"1990","unstructured":"Provost, P. R., Weech, P. K., Tremblay, N. M., Marcel, Y. L. & Rassart, E. (1990) Molecular characterization and differential mRNA tissue distribution of rabbit apolipoprotein D. Journal of Lipid Research\n31, 2057\u20132065.","journal-title":"Journal of Lipid Research"},{"key":"5123160_CR29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0167-4838(00)00162-X","volume":"1482","author":"E. Rassart","year":"2000","unstructured":"Rassart, E., Bedirian, A., Do Carmo, S., Guinard, O., Sirois, J., Terrisse, L. & Milne, R. (2000) Apolipoprotein D. Biochimica et Biophysica Acta\n1482, 185\u2013198.","journal-title":"Biochimica et Biophysica Acta"},{"key":"5123160_CR30","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0169-328X(95)00008-G","volume":"30","author":"D. Seguin","year":"1995","unstructured":"Seguin, D., Desforges, M. & Rassart, E. (1995) Molecular characterization and differential mRNA tissue distribution of mouse apolipoprotein D. Brain Research Molecular Brain Research\n30, 242\u2013250.","journal-title":"Brain Research Molecular Brain Research"},{"key":"5123160_CR31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1471-4159.1998.70010242.x","volume":"70","author":"S. Suresh","year":"1998","unstructured":"Suresh, S., Yan, Z., Patel, R. C., Patel, Y. C. & Patel, S. C. (1998) Cellular cholesterol storage in the Niemann-Pick disease type C mouse is associated with increased expression and defective processing of apolipoprotein D. Journal of Neurochemistry\n70, 242\u2013251.","journal-title":"Journal of Neurochemistry"},{"key":"5123160_CR32","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1046\/j.1471-4159.1998.71041643.x","volume":"71","author":"L. Terrisse","year":"1998","unstructured":"Terrisse, L., Poirier, J., Bertrand, P., Merched, A., Visvikis, S., Siest, G., Milne, R. & Rassart, E. (1998). Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients. Journal of Neurochemistry\n71, 1643\u20131650.","journal-title":"Journal of Neurochemistry"},{"key":"5123160_CR33","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1089\/dna.1996.15.873","volume":"15","author":"K. Yoshida","year":"1996","unstructured":"Yoshida, K., Cleaveland, E. S., Nagle, J. W., French, S., Yaswen, L., Ohshima, T., Brady, R. O., Pentchev, P. G. & Kulkarni, A. B. (1996) Molecular cloning of the mouse apolipoprotein D gene and its upregulated expression in Niemann-Pick disease type C mouse model. DNA Cell Biology\n15, 873\u2013882.","journal-title":"DNA Cell Biology"},{"key":"5123160_CR34","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1073\/pnas.93.13.6626","volume":"93","author":"C. Zeng","year":"1996","unstructured":"Zeng, C., Spielman, A. I., Vowels, B. R., Leyden, J. J., Biemann, K. & Preti, G. (1996) Ahuman axillary odorant is carried by apolipoprotein D. Proceedings of the National Academy of Sciences of the USA\n93, 6626\u20136630.","journal-title":"Proceedings of the National Academy of Sciences of the USA"}],"container-title":["Journal of Neurocytology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1023993405851.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1023993405851\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1023993405851.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T06:09:56Z","timestamp":1751868596000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1023993405851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["5123160"],"URL":"https:\/\/doi.org\/10.1023\/a:1023993405851","relation":{},"ISSN":["0300-4864","1573-7381"],"issn-type":[{"type":"print","value":"0300-4864"},{"type":"electronic","value":"1573-7381"}],"subject":[],"published":{"date-parts":[[2002,2]]}}}