{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:30:41Z","timestamp":1778203841846,"version":"3.51.4"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurooncol"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1023\/a:1024320516341","type":"journal-article","created":{"date-parts":[[2003,9,15]],"date-time":"2003-09-15T15:32:14Z","timestamp":1063639934000},"page":"247-256","source":"Crossref","is-referenced-by-count":15,"title":["Radioimmunoscintigraphy of Intracranial Glioma Xenograft with a Technetium-99m-Labeled Mouse Monoclonal Antibody Specifically Recognizing Type III Mutant Epidermal Growth Factor Receptor"],"prefix":"10.1007","volume":"63","author":[{"given":"Syuntaro","family":"Takasu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitada","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Oriuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Nakayashiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Muramatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norimoto","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiko","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Kozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Miyaishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Saga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuzo","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"5138402_CR1","first-page":"3217","volume":"53","author":"IE Garcia de Palazzo","year":"1993","unstructured":"Garcia de Palazzo IE, Adams GP, Sundareshan P, Wong AJ, Testa JR, Bigner DD, Weiner LM: Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas. Cancer Res 53: 3217\u20133220, 1993","journal-title":"Cancer Res"},{"key":"5138402_CR2","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3109\/13550289809114515","volume":"4","author":"CJ Wikstrand","year":"1998","unstructured":"Wikstrand CJ, Reist CJ, Archer GE, Zalutsky MR, Bigner DD: The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target. J Neurovirol 4: 148\u2013158, 1998","journal-title":"J Neurovirol"},{"key":"5138402_CR3","first-page":"5536","volume":"55","author":"DK Moscatello","year":"1995","unstructured":"Moscatello DK, Holgado-Madruga M, Godwin AK, Ramirez G, Gunn G, Zoltick PW, Biegel JA, Hayes RL, Wong AJ: Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors. Cancer Res 55: 5536\u20135539, 1995","journal-title":"Cancer Res"},{"key":"5138402_CR4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1136\/jcp.52.8.574","volume":"52","author":"A Korshunov","year":"1999","unstructured":"Korshunov A, Golanov A, Sycheva R, Pronin I: Prognostic value of tumour associated antigen immunoreactivity and apoptosis in cerebral glioblastomas: an analysis of 168 cases. J Clin Pathol 52: 574\u2013580, 1999","journal-title":"J Clin Pathol"},{"key":"5138402_CR5","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/jnci\/90.11.824","volume":"90","author":"JR Grandis","year":"1998","unstructured":"Grandis JR, Melhem MF, Gooding WE, Day R, Holst VA, Wagener MM, Drenning SD, Tweardy DJ: Levels of TGFalpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 90: 824\u2013832, 1998","journal-title":"J Natl Cancer Inst"},{"key":"5138402_CR6","doi-asserted-by":"crossref","first-page":"5724","DOI":"10.1073\/pnas.95.10.5724","volume":"95","author":"M Nagane","year":"1998","unstructured":"Nagane M, Levitzki A, Gazit A, Cavenee WK, Huang HJ: Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases. Proc Natl Acad Sci USA 95: 5724\u20135729, 1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"5138402_CR7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1023\/A:1005812417638","volume":"35","author":"DM Ashley","year":"1997","unstructured":"Ashley DM, Batra SK, Bigner DD: Monoclonal antibodies to growth factors and growth factor receptors: their diagnostic and therapeutic potential in brain tumors. J Neuro-Oncol 35: 259\u2013273, 1997","journal-title":"J Neuro-Oncol"},{"key":"5138402_CR8","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1073\/pnas.89.7.2965","volume":"89","author":"AJ Wong","year":"1992","unstructured":"Wong AJ, Ruppert JM, Bigner SH, Grzeschik CH, Humphrey PA, Bigner DS, Vogelstein B: Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci USA 89: 2965\u20132969, 1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"5138402_CR9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1023\/A:1006354102377","volume":"18","author":"CJ Wikstrand","year":"1999","unstructured":"Wikstrand CJ, Cokgor I, Sampson JH, Bigner DD: Monoclonal antibody therapy of human gliomas: current status and future approaches. Cancer Metastasis Rev 18: 451\u2013464, 1999","journal-title":"Cancer Metastasis Rev"},{"key":"5138402_CR10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.1349-7006.1990.tb02644.x","volume":"81","author":"H Yamazaki","year":"1990","unstructured":"Yamazaki H, Ohba Y, Tamaoki N, Shibuya M: A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors. Jpn J Cancer Res 81: 773\u2013779, 1990","journal-title":"Jpn J Cancer Res"},{"key":"5138402_CR11","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1073\/pnas.87.21.8602","volume":"87","author":"N Sugawa","year":"1990","unstructured":"Sugawa N, Ekstrand AJ, James CD, Collins VP: Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas. Proc Natl Acad Sci USA 87: 8602\u20138606, 1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"5138402_CR12","first-page":"2231","volume":"48","author":"PA Humphrey","year":"1988","unstructured":"Humphrey PA, Wong AJ, Vogelstein B, Friedman HS, Werner MH, Bigner DD, Bigner SH: Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. Cancer Res 48: 2231\u20132238, 1988","journal-title":"Cancer Res"},{"key":"5138402_CR13","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1073\/pnas.87.11.4207","volume":"87","author":"PA Humphrey","year":"1990","unstructured":"Humphrey PA, Wong AJ, Vogelstein B, Zalutsky MR, Fuller GN, Archer GE, Friedman HS, Kwatra MM, Bigner SH, Bigner DD: Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma. Proc Natl Acad Sci USA 87: 4207\u20134211, 1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"5138402_CR14","first-page":"4130","volume":"57","author":"CJ Wikstrand","year":"1997","unstructured":"Wikstrand CJ, McLendon RE, Friedman AH, Bigner DD: Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. Cancer Res 57: 4130\u20134140, 1997","journal-title":"Cancer Res"},{"key":"5138402_CR15","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1054\/bjoc.1999.0898","volume":"82","author":"EO Olapade-Olaopa","year":"2000","unstructured":"Olapade-Olaopa EO, Moscatello DK, MacKay EH, Horsburgh T, Sandhu DP, Terry TR, Wong AJ, Habib FK: Evidence for the differential expression of a variant EGF receptor protein in human prostate cancer. Br J Cancer 82: 186\u2013194, 2000","journal-title":"Br J Cancer"},{"key":"5138402_CR16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/ijc.10224","volume":"98","author":"H Ge","year":"2002","unstructured":"Ge H, Gong X, Tang CK: Evidence of high incidence of EGFRvIII expression and coexpression with EGFR in human invasive breast cancer by laser capture microdissection and immunohistochemical analysis. Int J Cancer 98: 357\u2013361, 2002","journal-title":"Int J Cancer"},{"key":"5138402_CR17","first-page":"3140","volume":"55","author":"CJ Wikstrand","year":"1995","unstructured":"Wikstrand CJ, Hale LP, Batra SK, Hill ML, Humphrey PA, Kurpad SN, McLendon RE, Moscatello D, Pegram CN, Reist CJ: Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res 55: 3140\u20133148, 1995","journal-title":"Cancer Res"},{"key":"5138402_CR18","doi-asserted-by":"crossref","first-page":"7727","DOI":"10.1073\/pnas.91.16.7727","volume":"91","author":"R Nishikawa","year":"1994","unstructured":"Nishikawa R, Ji XD, Harmon RC, Lazar CS, Gill GN, Cavenee WK, Huang HJ: A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA 91: 7727\u20137731, 1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"5138402_CR19","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1097\/00006123-199912000-00034","volume":"45","author":"MM Feldkamp","year":"1999","unstructured":"Feldkamp MM, Lala P, Lau N, Roncari L, Guha A: Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens. Neurosurgery 45: 1442\u20131453, 1999","journal-title":"Neurosurgery"},{"key":"5138402_CR20","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/ijc.2910630414","volume":"63","author":"D Hills","year":"1995","unstructured":"Hills D, Rowlinson-Busza G, Gullick WJ: Specific targeting of a mutant, activated FGF receptor found in glioblastoma using a monoclonal antibody. Int J Cancer 63: 537\u2013543, 1995","journal-title":"Int J Cancer"},{"key":"5138402_CR21","first-page":"5349","volume":"61","author":"K Mishima","year":"2001","unstructured":"Mishima K, Johns TG, Luwor RB, Scott AM, Stockert E, Jungbluth AA, Ji XD, Suvarna P, Voland JR, Old LJ, Huang HJ, Cavenee WK:Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor. Cancer Res 61: 5349\u20135354, 2001","journal-title":"Cancer Res"},{"key":"5138402_CR22","first-page":"5355","volume":"61","author":"RB Luwor","year":"2001","unstructured":"Luwor RB, Johns TG, Murone C, Huang HJ, Cavenee WK, Ritter G, Old LJ, Burgess AW, Scott AM: Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR. Cancer Res 61: 5355\u20135361, 2001","journal-title":"Cancer Res"},{"key":"5138402_CR23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000059704","volume":"23","author":"L Ohman","year":"2002","unstructured":"Ohman L, Gedda L, Hesselager G, Larsson R, Nister M, Stigbrand T, Wester K, Carlsson J: A new antibody recognizing the vIII mutation of human epidermal growth factor receptor. Tumour Biol 23: 61\u201369, 2002","journal-title":"Tumour Biol"},{"key":"5138402_CR24","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/bjc.1996.260","volume":"73","author":"S Okamoto","year":"1996","unstructured":"Okamoto S, Yoshikawa K, Obata Y, Shibuya M, Aoki S, Yoshida J, Takahashi T: Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor. Br J Cancer 73: 1366\u20131372, 1996","journal-title":"Br J Cancer"},{"key":"5138402_CR25","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1349-7006.2000.tb00882.x","volume":"91","author":"N Nakayashiki","year":"2000","unstructured":"Nakayashiki N, Yoshikawa K, Nakamura K, Hanai N, Okamoto K, Okamoto S, Mizuno M, Wakabayashi T, Saga S, Yoshida J, Takahashi T: Production of a single-chain variable fragment antibody recognizing type III mutant epidermal growth factor receptor. Jpn J Cancer Res 91: 1035\u20131043, 2000","journal-title":"Jpn J Cancer Res"},{"key":"5138402_CR26","first-page":"593","volume":"41","author":"K Mitsui","year":"1995","unstructured":"Mitsui K, Taki T, Miyagawa Y, Yamada Y, Honda N, Fukatsu H, Yoshikawa K, Segawa A: Scintigraphic detection of xenografted renal tumor by anti-renal cancer monoclonal antibody radiolabeled with technetium-99m. Hinyokika Kiyo 41: 593\u2013601, 1995","journal-title":"Hinyokika Kiyo"},{"key":"5138402_CR27","first-page":"685","volume":"27","author":"BA Rhodes","year":"1986","unstructured":"Rhodes BA, Zamora PO, Newell KD, Valdez EF: Technetium-99m labeling of murine monoclonal antibody fragments. J Nucl Med 27: 685\u2013693, 1986","journal-title":"J Nucl Med"},{"key":"5138402_CR28","first-page":"692","volume":"31","author":"SJ Mather","year":"1990","unstructured":"Mather SJ, Ellison D: Reduction-mediated technetium-99m labeling of monoclonal antibodies. J Nucl Med 31: 692\u2013697, 1990","journal-title":"J Nucl Med"},{"key":"5138402_CR29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF02482738","volume":"17","author":"CT Kuan","year":"2000","unstructured":"Kuan CT, Wikstrand CJ, Bigner DD: EGFRvIII as a promising target for antibody-based brain tumor therapy. Brain Tumor Pathol 17: 71\u201378, 2000","journal-title":"Brain Tumor Pathol"},{"key":"5138402_CR30","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/0161-5890(95)00052-G","volume":"32","author":"TK Nikula","year":"1995","unstructured":"Nikula TK, Bocchia M, Curcio MJ, Sgouros G, Ma Y, Finn RD, Scheinberg DA: Impact of the high tyrosine fraction in complementarity determining regions: measured and predicted effects of radioiodination on IgG immunoreactivity. Mol Immunol 32: 865\u2013872, 1995","journal-title":"Mol Immunol"},{"key":"5138402_CR31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/ijc.10189","volume":"98","author":"TG Johns","year":"2002","unstructured":"Johns TG, Stockert E, Ritter G, Jungbluth AA, Huang HJ, Cavenee WK, Smyth FE, Hall CM, Watson N, Nice EC, Gullick WJ, Old LJ, Burgess AW, Scott AM: Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene. Int J Cancer 98: 398\u2013408, 2002","journal-title":"Int J Cancer"},{"key":"5138402_CR32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/jso.2930230318","volume":"23","author":"DS Reintgen","year":"1983","unstructured":"Reintgen DS, Shimizu K, Coleman E, Briner W, Kitzmiller J, Eisenbarth G, Seigler HF: Immunodiagnosis of tumors in vivo using radiolabeled monoclonal antibody A2B5. J Surg Oncol 23: 205\u2013211, 1983","journal-title":"J Surg Oncol"},{"key":"5138402_CR33","first-page":"1191","volume":"31","author":"K Fujimori","year":"1990","unstructured":"Fujimori K, Covell DG, Fletcher JE, Weinstein JN: A modeling analysis of monoclonal antibody percolation through tumors: a binding-site barrier. J Nucl Med 31: 1191\u20131198, 1990","journal-title":"J Nucl Med"},{"key":"5138402_CR34","first-page":"4750","volume":"61","author":"GP Adams","year":"2001","unstructured":"Adams GP, Schier R, McCallA M, Simmons HH, Horak EM, Alpaugh RK, Marks JD, Weiner LM: High affinity restricts the localization and tumor penetration of singlechain fv antibody molecules. Cancer Res 61: 4750\u20134755, 2001","journal-title":"Cancer Res"},{"key":"5138402_CR35","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1200\/JCO.2002.20.5.1389","volume":"20","author":"DA Reardon","year":"2002","unstructured":"Reardon DA, Akabani G, Coleman RE, Friedman AH, Friedman HS, Herndon JE 2nd, Cokgor I, McLendon RE, Pegram CN, Provenzale JM, Quinn JA, Rich JN, Regalado LV, Sampson JH, Shafman TD, Wikstrand CJ, Wong TZ, Zhao XG, Zalutsky MR, Bigner DD: Phase II trial of murine (131)I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas. J Clin Oncol 20: 1389\u20131397, 2002","journal-title":"J Clin Oncol"},{"key":"5138402_CR36","first-page":"243","volume":"34","author":"LW Brady","year":"1990","unstructured":"Brady LW, Markoe AM, Woo DV, Rackover MA, Koprowski H, Steplewski Z, Peyster RG: Iodine125 labeled anti-epidermal growth factor receptor-425 in the treatment of malignant astrocytomas. A pilot study. J Neurosurg Sci 34: 243\u2013249, 1990","journal-title":"J Neurosurg Sci"}],"container-title":["Journal of Neuro-Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1024320516341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1024320516341\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1024320516341.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:01:06Z","timestamp":1749632466000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1024320516341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["5138402"],"URL":"https:\/\/doi.org\/10.1023\/a:1024320516341","relation":{},"ISSN":["0167-594X","1573-7373"],"issn-type":[{"value":"0167-594X","type":"print"},{"value":"1573-7373","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}