{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:50:38Z","timestamp":1772895038017,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biometals"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1023\/a:1024417309370","type":"journal-article","created":{"date-parts":[[2003,9,15]],"date-time":"2003-09-15T17:22:37Z","timestamp":1063646557000},"page":"15-24","source":"Crossref","is-referenced-by-count":17,"title":["Regulation of p27Kip1 by intracellular iron levels"],"prefix":"10.1007","volume":"17","author":[{"given":"Gang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Miskimins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Keith","family":"Miskimins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"5123312_CR1","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0955-0674(00)00280-5","volume":"13","author":"J Bartek","year":"2001","unstructured":"Bartek, J and Lukas, J. 2001 Mammalian G1-and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol\n13, 738\u2013747.","journal-title":"Curr Opin Cell Biol"},{"key":"5123312_CR2","first-page":"3968","volume":"53","author":"C Brodie","year":"1993","unstructured":"Brodie, C, Siriwardana, G, Lucas, J, et al. 1993 Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle. Cancer Res\n53, 3968\u20133975.","journal-title":"Cancer Res"},{"key":"5123312_CR3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s007260170050","volume":"20","author":"M Caraglia","year":"2001","unstructured":"Caraglia, M, Marra, M, Giuberti, G, et al. 2001 The role of eukaryotic initiation factor 5A in the control of cell proliferation and apoptosis. Amino Acids\n20, 91\u2013104.","journal-title":"Amino Acids"},{"key":"5123312_CR4","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-4757-3230-6_16","volume":"472","author":"M Caraglia","year":"1999","unstructured":"Caraglia, M, Tagliaferri, P, Budillon, A and Abbruzzese, A. 1999 Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anticancer therapy. Adv Exp Med Biol\n472, 187\u2013198.","journal-title":"Adv Exp Med Biol"},{"key":"5123312_CR5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/ijc.10515","volume":"100","author":"PM Clement","year":"2002","unstructured":"Clement, PM, Hanauske-Abel, HM, Wolff, EC, Kleinman, HK and Park, MH. 2002 The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro. Int J Cancer\n100, 491\u2013498.","journal-title":"Int J Cancer"},{"key":"5123312_CR6","doi-asserted-by":"crossref","first-page":"20291","DOI":"10.1074\/jbc.271.34.20291","volume":"271","author":"CE Cooper","year":"1996","unstructured":"Cooper, CE, Lynagh, GR, Hoyes, KP, et al. 1996 The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. J Biol Chem\n271, 20291\u201320299.","journal-title":"J Biol Chem"},{"key":"5123312_CR7","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1182\/blood.V94.2.781","volume":"94","author":"G Darnell","year":"1999","unstructured":"Darnell, G and Richardson, DR. 1999 The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents III: the effect of the ligands on molecular targets involved in proliferation. Blood\n94, 781\u2013792.","journal-title":"Blood"},{"key":"5123312_CR8","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0968-0004(92)90249-9","volume":"17","author":"SJ Elledge","year":"1992","unstructured":"Elledge, SJ, Zhou, Z and Allen, JB. 1992 Ribonucleotide reductase: regulation, regulation, regulation. Trends Biochem Sci\n17, 119\u2013123.","journal-title":"Trends Biochem Sci"},{"key":"5123312_CR9","first-page":"1073","volume":"61","author":"L Fan","year":"2001","unstructured":"Fan, L, Iyer, J, Zhu, S, et al. 2001 Inhibition of N-myc expression and induction of apoptosis by iron chelation in human neuroblastoma cells. Cancer Res\n61, 1073\u20131079.","journal-title":"Cancer Res"},{"key":"5123312_CR10","doi-asserted-by":"crossref","first-page":"4718","DOI":"10.1038\/sj.onc.1204647","volume":"20","author":"T Furukawa","year":"2001","unstructured":"Furukawa, T, Adachi, Y, Fujisawa, J, et al. 2001 Involvement of PLAGL2 in activation of iron deficient-and hypoxia-induced gene expression in mouse cell lines. Oncogene\n20, 4718\u20134727.","journal-title":"Oncogene"},{"key":"5123312_CR11","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1182\/blood.V98.3.842","volume":"98","author":"Gao, J","year":"2001","unstructured":"Gao, J and Richardson, DR. 2001 The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents, IV: The mechanisms involved in inhibiting cell-cycle progression. Blood\n98, 842\u2013850.","journal-title":"Blood"},{"key":"5123312_CR12","first-page":"7919","volume":"276","author":"LB Gardner","year":"2001","unstructured":"Gardner, LB, Li, Q, Park, MS, et al. 2001 Hypoxia inhibits G1\/S transition through regulation of p27 expression. J BiolChem\n276, 7919\u20137926.","journal-title":"J BiolChem"},{"key":"5123312_CR13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jcp.1041130109","volume":"113","author":"TA. Hamilton","year":"1982","unstructured":"Hamilton, TA. 1982 Regulation of transferrin receptor expression in concanavalin A stimulated and Gross virus transformed rat lymphoblasts. J Cell Physiol\n113, 40\u201346.","journal-title":"J Cell Physiol"},{"key":"5123312_CR14","first-page":"4591","volume":"52","author":"KP Hoyes","year":"1992","unstructured":"Hoyes, KP, Hider, RC and Porter, JB. 1992 Cell cycle synchronization and growth I nhibition by 3-hydroxypyridin-4-one iron chelators in leukemia cell lines. Cancer Res\n52, 4591\u20134599.","journal-title":"Cancer Res"},{"key":"5123312_CR15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1042\/bj3630431","volume":"363","author":"O Kakhlon","year":"2002","unstructured":"Kakhlon, O, Gruenbaum, Y and Cabantchik, ZI. 2002 Ferritin expression modulates cell cycle dynamics and cell responsiveness to H-ras-induced growth via expansion of the labile iron pool. Biochem J\n363, 431\u2013436.","journal-title":"Biochem J"},{"key":"5123312_CR16","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/jmbi.1996.0546","volume":"262","author":"B Kauppi","year":"1996","unstructured":"Kauppi, B, Nielsen, BB, Ramaswamy, S, et al. 1996 The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible ironradical site than Escherichia coli R2. J Mol Biol\n262, 706\u2013720.","journal-title":"J Mol Biol"},{"key":"5123312_CR17","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/sj.onc.1202159","volume":"17","author":"A Krtolica","year":"1998","unstructured":"Krtolica, A, Krucher, NA and Ludlow, JW. 1998 Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities. Oncogene\n17, 2295\u20132304.","journal-title":"Oncogene"},{"key":"5123312_CR18","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1038\/sj.bjc.6690615","volume":"80","author":"A Krtolica","year":"1999","unstructured":"Krtolica, A, Krucher, NA and Ludlow, JW. 1999 Molecular analysis of selected cell cycle regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells. Br J Cancer\n80, 1875\u20131883.","journal-title":"Br J Cancer"},{"key":"5123312_CR19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1006\/excr.1996.0343","volume":"229","author":"KS Kulp","year":"1996","unstructured":"Kulp, KS, Green, SL and Vulliet, PR. 1996 Iron deprivation inhibits cyclin-dependent kinase activity and decreases cyclin D\/CDK4 protein levels in asynchronous MDA-MB-453 human breast cancer cells. Exp Cell Res\n229, 60\u201368.","journal-title":"Exp Cell Res"},{"key":"5123312_CR20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1040-8428(01)00213-X","volume":"42","author":"JC Kwok","year":"2002","unstructured":"Kwok, JC and Richardson, DR. 2002 The iron metabolism of neoplastic cells: alterations that facilitate proliferation? Crit Rev Oncol Hematol\n42, 65\u201378.","journal-title":"Crit Rev Oncol Hematol"},{"key":"5123312_CR21","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jss.400110415","volume":"11","author":"JW Larrick","year":"1979","unstructured":"Larrick, JW and Cresswell, P. 1979 Modulation of cell surface iron transferrin receptors by cellular density and state of activation. J Supramol Struct\n11, 579\u2013586.","journal-title":"J Supramol Struct"},{"key":"5123312_CR22","first-page":"1814","volume":"5","author":"JF Lesley","year":"1985","unstructured":"Lesley, JF and Schulte, RJ. 1985 Inhibition of cell growth by monoclonal anti-transferrin receptor antibodies. Mol Cell Biol\n5, 1814\u20131821.","journal-title":"Mol Cell Biol"},{"key":"5123312_CR23","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1182\/blood.V86.6.2268.bloodjournal8662268","volume":"86","author":"JJ Lucas","year":"1995","unstructured":"Lucas, JJ, Szepesi, A, Domenico, J, et al. 1995 Effects of iron-depletion on cell cycle progression in normal human T lymphocytes: selective inhibition of the appearance of the cyclin A-associated component of the p33cdk2 kinase. Blood\n86, 2268\u20132280.","journal-title":"Blood"},{"key":"5123312_CR24","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.4049\/jimmunol.148.6.1804","volume":"148","author":"JJ Lucas","year":"1992","unstructured":"Lucas, JJ, Terada, N, Szepesi, A and Gelfand, EW. 1992 Regulation of synthesis of p34cdc2 and its homologues and their relationship to p110Rb phosphorylation during cell cycle progression of normal human T cells. J Immunol\n148, 1804\u20131811.","journal-title":"J Immunol"},{"key":"5123312_CR25","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1021\/bi00221a030","volume":"30","author":"GJ Mann","year":"1991","unstructured":"Mann, GJ, Graslund, A, Ochiai, E, Ingemarson, R and Thelander, L. 1991 Purification and characterization of recombinant mouse and herpes simplex virus ribonucleotide reductase R2 subunit. Biochemistry\n30, 1939\u20131947.","journal-title":"Biochemistry"},{"key":"5123312_CR26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0955-0674(02)00312-5","volume":"14","author":"J Melo","year":"2002","unstructured":"Melo, J and Toczyski, D. 2002 A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol\n14, 237\u2013245.","journal-title":"Curr Opin Cell Biol"},{"key":"5123312_CR27","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1083\/jcb.103.5.1781","volume":"103","author":"WK Miskimins","year":"1986","unstructured":"Miskimins, WK, McClelland, A, Roberts, MP and Ruddle, FH. 1986 Cell proliferation and expression of the transferrin receptor gene: promoter sequence homologies and protein interactions. J Cell Biol\n103, 1781\u20131788.","journal-title":"J Cell Biol"},{"key":"5123312_CR28","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1073\/pnas.80.11.3494","volume":"80","author":"LM Neckers","year":"1983","unstructured":"Neckers, LM and Cossman, J. 1983 Transferrin receptor induction in mitogenstimulated human T lymphocytes is required for DNA synthesis and cell division and is regulated by interleukin 2. Proc Natl Acad Sci USA\n80, 3494\u20133498.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5123312_CR29","doi-asserted-by":"crossref","first-page":"26200","DOI":"10.1016\/S0021-9258(19)74300-2","volume":"268","author":"S Nyholm","year":"1993","unstructured":"Nyholm, S, Mann, GJ, Johansson, AG, et al. 1993 Role of ribonucleotide reductase in inhibition of mammalian cell growth by potent iron chelators. J Biol Chem\n268, 26200\u201326205.","journal-title":"J Biol Chem"},{"key":"5123312_CR30","first-page":"1796","volume":"13","author":"Q Ouyang","year":"1993","unstructured":"Ouyang, Q, Bommakanti, M and Miskimins, WK. 1993 A mitogen-responsive promoter region that is synergistically activated through multiple signalling pathways. Mol Cell Biol\n13, 1796\u20131804.","journal-title":"Mol Cell Biol"},{"key":"5123312_CR31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1159\/000109117","volume":"6","author":"MH Park","year":"1997","unstructured":"Park, MH, Lee, YB and Joe, YA. 1997 Hypusine is essential for eukaryotic cell proliferation. Biol Signals\n6, 115\u2013123.","journal-title":"Biol Signals"},{"key":"5123312_CR32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1006\/excr.2000.5143","volume":"264","author":"J PhilippStaheli","year":"2001","unstructured":"PhilippStaheli, J, Payne, SR and Kemp, CJ. 2001 p27Kip1: regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Exp Cell Res\n264, 148\u2013168.","journal-title":"Exp Cell Res"},{"key":"5123312_CR33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1040-8428(01)00218-9","volume":"42","author":"DR. Richardson","year":"2002","unstructured":"Richardson, DR. 2002 Iron chelators as therapeutic agents for the treatment of cancer. Crit Rev Oncol Hematol\n42, 267\u2013281.","journal-title":"Crit Rev Oncol Hematol"},{"key":"5123312_CR34","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1091\/mbc.8.9.1815","volume":"8","author":"P Shiyanov","year":"1997","unstructured":"Shiyanov, P, Hayes, S, Chen, N, et al. 1997 p27Kip1 induces an accumulation of the repressor complexes of E2F and inhibits expression of the E2F-regulated genes. Mol Biol Cell\n8, 1815\u20131827.","journal-title":"Mol Biol Cell"},{"key":"5123312_CR35","first-page":"1759","volume":"46","author":"R Taetle","year":"1986","unstructured":"Taetle, R, Castagnola, J and Mendelsohn, J. 1986 Mechanisms of growth inhibition by anti-transferrin receptor monoclonal antibodies. Cancer Res\n46, 1759\u20131763.","journal-title":"Cancer Res"},{"key":"5123312_CR36","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/0006-291X(83)91040-9","volume":"110","author":"L Thelander","year":"1983","unstructured":"Thelander, L, Graslund, A and Thelander, M. 1983 Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: possible regulation mechanism. Biochem Biophys Res Commun\n110, 859\u2013865.","journal-title":"Biochem Biophys Res Commun"},{"key":"5123312_CR37","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1073\/pnas.79.4.1175","volume":"79","author":"IS Trowbridge","year":"1982","unstructured":"Trowbridge, IS and Lopez, F. 1982 Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro. Proc Natl Acad Sci USA\n79, 1175\u20131179.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5123312_CR38","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1073\/pnas.78.5.3039","volume":"78","author":"IS Trowbridge","year":"1981","unstructured":"Trowbridge, IS and Omary, MB. 1981 Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin. Proc Natl Acad Sci USA\n78, 3039\u20133043.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5123312_CR39","doi-asserted-by":"crossref","first-page":"8835","DOI":"10.1073\/pnas.95.15.8835","volume":"95","author":"A Varrault","year":"1998","unstructured":"Varrault, A, Ciani, E, Apiou, F, et al. 1998 hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer. Proc Natl Acad Sci USA\n95, 8835\u20138840.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5123312_CR40","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1182\/blood.V82.12.3610.3610","volume":"82","author":"GL Wang","year":"1993","unstructured":"Wang, GL and Semenza, GL. 1993 Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood\n82, 3610\u20133615.","journal-title":"Blood"},{"key":"5123312_CR41","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.283.5402.676","volume":"283","author":"KJ Wu","year":"1999","unstructured":"Wu, KJ, Polack, A and Dalla-Favera, R. 1999 Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC. Science\n283, 676\u2013679.","journal-title":"Science"},{"key":"5123312_CR42","first-page":"1777","volume":"21","author":"DC Yang","year":"2001","unstructured":"Yang, DC, Jiang, XP, Elliott, RL and Head, JF. 2001 Inhibition of growth of human breast carcinoma cells by an antisense oligonucleotide targeted to the transferrin receptor gene. Anticancer Res\n21, 1777\u20131787.","journal-title":"Anticancer Res"},{"key":"5123312_CR43","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1042\/bj20011445","volume":"366","author":"G Yoon","year":"2002","unstructured":"Yoon, G, Kim, HJ, Yoon, YS, et al. 2002 Iron chelation-induced senescence-like growth 613-621.arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression. Biochem J\n366, 613\u2013621.","journal-title":"Biochem J"}],"container-title":["Biometals"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1024417309370.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1024417309370\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1024417309370.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T17:18:00Z","timestamp":1749575880000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1024417309370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["5123312"],"URL":"https:\/\/doi.org\/10.1023\/a:1024417309370","relation":{},"ISSN":["0966-0844","1572-8773"],"issn-type":[{"value":"0966-0844","type":"print"},{"value":"1572-8773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}