{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:21:48Z","timestamp":1791030108001,"version":"4.1.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Pharmacokinet Pharmacodyn"],"published-print":{"date-parts":[[1997,8]]},"DOI":"10.1023\/a:1025740909016","type":"journal-article","created":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T18:33:40Z","timestamp":1067020420000},"page":"413-447","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Physiologically Based Pharmacokinetic Modeling of a Homologous Series of Barbiturates in the Rat: A Sensitivity Analysis"],"prefix":"10.1007","volume":"25","author":[{"given":"Ivan A.","family":"Nestorov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon J.","family":"Aarons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"424815_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0010-2180(85)90019-7","volume":"59","author":"R. A. Yetter","year":"1985","unstructured":"R. A. Yetter, F. L. Dryer, and H. Rabitz. Some interpretative aspects of elementary sensitivity gradients in combustion kinetics modeling. Combust. Flame\n59:107\u2013133 (1985).","journal-title":"Combust. Flame"},{"key":"424815_CR2","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1006\/taap.1994.1177","volume":"128","author":"M. V. Evans","year":"1994","unstructured":"M. V. Evans, W. D. Crank, H-M. Yang, and J. E. Simmons. Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats. Toxicol. Appl. Pharmacol.\n128:36\u201344 (1994).","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"424815_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01062190","volume":"19","author":"D. M. Hetrick","year":"1991","unstructured":"D. M. Hetrick, A. M. Jarabek, and C. C. Travis. Sensitivity analysis for physiologically based pharmacokinetic models. J. Pharmacokin. Biopharm.\n19:1\u201320 (1991).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"424815_CR4","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/jps.2600840322","volume":"84","author":"P. Varkonyi","year":"1995","unstructured":"P. Varkonyi, J. V. Bruckner, and J. M. Gallo. Effect of parameter variability on physiologically based pharmacokinetic model predicted drug concentrations. J. Pharm. Sci.\n84:381\u2013384 (1995).","journal-title":"J. Pharm. Sci."},{"key":"424815_CR5","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/j.1539-6924.1991.tb00653.x","volume":"11","author":"R. C. Spear","year":"1991","unstructured":"R. C. Spear, F. Y. Bois, T. Woodruff, D. Auslander, J. Parker, and S. Selvin. Modeling benzene pharmacokinetics across three sets of animal data: Parametric sensitivity and risk implications. Risk Anal.\n11:641\u2013654 (1991).","journal-title":"Risk Anal."},{"key":"424815_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0169-2607(94)90046-9","volume":"42","author":"K. Thomaseth","year":"1994","unstructured":"K. Thomaseth. PANSYM: A symbolic equation generator for mathematical modelling, analysis and control of metabolic and pharmacokinetic systems. Comput. Meth. Prog. Biomed.\n42:99\u2013112 (1994).","journal-title":"Comput. Meth. Prog. Biomed."},{"key":"424815_CR7","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1002\/bit.260411105","volume":"41","author":"P. M. Schlosser","year":"1993","unstructured":"P. M. Schlosser, T. Holcomb, and J. E. Bailey. Determining metabolic sensitivity coefficient directly from experimental data. Biotech. Bioeng.\n41:1027\u20131038 (1993).","journal-title":"Biotech. Bioeng."},{"key":"424815_CR8","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/j.1539-6924.1994.tb00241.x","volume":"14","author":"J. H. Clewell","year":"1994","unstructured":"J. H. Clewell and B. M. Jarnot. Incorporation of pharmacokinetics in noncancer risk assessment: Example with chloropentafluorobenzene. Risk Anal.\n14:265\u2013276 (1994).","journal-title":"Risk Anal."},{"key":"424815_CR9","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1023\/A:1025771608474","volume":"25","author":"G. Blakey","year":"1997","unstructured":"G. Blakey, I. Nestorov, P. Arundel, L. Aarons, and M. Rowland. Quantitative structure-pharmacokinetics relationships: I. Development of a whole-body physiologically based model to characterize changes in pharmacokinetics across a homologous series of barbiturates in the rat. J. Pharmacokin. Biopharm.\n25:277\u2013312 (1997).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"424815_CR10","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1248\/cpb.15.1883","volume":"15","author":"K. Kakemi","year":"1967","unstructured":"K. Kakemi, T. Arita, R. Hori, and R. Konishi. Absorption and excretion of drugs. XXXII: Absorption of barbituric acid derivatives from rat small intestine. Chem. Pharm. Bull.\n15:1883\u20131887 (1967).","journal-title":"Chem. Pharm. Bull."},{"key":"424815_CR11","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1023\/A:1018943613122","volume":"10","author":"B. Davies","year":"1993","unstructured":"B. Davies and T. Morris. Physiological parameters in laboratory animals and humans. Pharm. Res.\n10:1093\u20131095 (1993).","journal-title":"Pharm. Res."},{"key":"424815_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/BF01062191","volume":"19","author":"A. Bernareggi","year":"1991","unstructured":"A. Bernareggi and M. Rowland. Physiological modeling of cyclosporine kinetics in rat and man. J. Pharmacokin. Biopharm.\n19:21\u201350 (1991).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"424815_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/BF01059779","volume":"21","author":"S. Bjorkman","year":"1993","unstructured":"S. Bjorkman, D. R. Stanski, H. Harashima, R. Dowrie, S. R. Harapat, D. R. Wada, and W. F. Ebling. Tissue distribution of fentanyl and alfentanil in the rat cannot be described by a blood flow limited model. J. Pharmacokin. Biopharm.\n21:255\u2013279 (1993).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"424815_CR14","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/BF02353862","volume":"22","author":"S. Bjorkman","year":"1994","unstructured":"S. Bjorkman, D. R. Wada, D. R. Stanski, and W. F. Ebling. Comparative pharmacokinetics of fentanyl and alfentanil inrats and humans based on parametric single-tissue models. J. Pharmacokin. Biopharm.\n22:381\u2013410 (1994).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"424815_CR15","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/BF02353860","volume":"22","author":"R. Kawai","year":"1994","unstructured":"R. Kawai, M. Lemaire, J-L. Steimer, A. Bruelisauer, W. Niederberger, and M. Rowland. Physiologically based pharmacokinetic study on a cyclosporine derivative, SDZ IMM 125. J. Pharmacokin. Biopharm.\n22:327\u2013365 (1994).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"424815_CR16","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1002\/jps.2600721003","volume":"72","author":"L. E. Gerlovski","year":"1983","unstructured":"L. E. Gerlovski and R. K. Jain. Physiologically based pharmacokinetic modeling: Principles and applications. J. Pharm. Sci.\n72:1103\u20131129 (1983).","journal-title":"J. Pharm. Sci."},{"key":"424815_CR17","volume-title":"Compartmental Models and Their Application","author":"K. Godfrey","year":"1983","unstructured":"K. Godfrey. Compartmental Models and Their Application. Academic Press, New York, 1983."},{"key":"424815_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-51861-4","volume-title":"Compartmental Modeling and Tracer Kinetics. Lecture Notes in Biomathematics","author":"D. A. Anderson","year":"1983","unstructured":"D. A. Anderson, Compartmental Modeling and Tracer Kinetics. Lecture Notes in Biomathematics, Vol. 50. Springer-Verlag, New York. 1983."},{"key":"424815_CR19","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1088\/0031-9155\/34\/12\/002","volume":"34","author":"V. Dhawan","year":"1989","unstructured":"V. Dhawan, A. Poltorak, J. R. Moeller, J. O. Jarden, S. Strother, H. Thaler, and D. A. Rottenberg. Positron emission tomographic measurement of blood-to-brain and blood-to-tumor transport of 82Rb: I. Error analysis and computer simulations. Phys. Med. Biol.\n34:1773\u20131784 (1989).","journal-title":"Phys. Med. Biol."},{"key":"424815_CR20","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/BF01062260","volume":"16","author":"J. L. Gabrielsson","year":"1988","unstructured":"J. L. Gabrielsson and T. Groth. An extended physiological pharmacokinetic model of methadone disposition in the rat: Vaiidation and sensitivity analysis. J. Pharmacokin. Biopharm.\n16:183\u2013201 (1988).","journal-title":"J. Pharmacokin. Biopharm."},{"key":"424815_CR21","volume-title":"Theory of Matrices","author":"P. Lancaster","year":"1969","unstructured":"P. Lancaster. Theory of Matrices, Academic Press, New York, 1969."},{"key":"424815_CR22","first-page":"328","volume-title":"Fundamentals of Matrix Computations","author":"D. E. Watkins","year":"1991","unstructured":"D. E. Watkins. Fundamentals of Matrix Computations, Wiley, New York, 1991, p. 328."},{"key":"424815_CR23","unstructured":"G. H. Golub. and C. F. Van Loan. Matrix Computations. Johns Hopkins University Press, 1983. p. 202."},{"key":"424815_CR24","unstructured":"MATLAB Manual. University of Manchester Regional Computer Center, NAT 657, 1988."},{"key":"424815_CR25","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-01632-9","volume-title":"Theory of sensitivity in dynamic systems. An Introduction","author":"M. Eslami","year":"1994","unstructured":"M. Eslami. Theory of sensitivity in dynamic systems. An Introduction, Springer Verlag, Heidelberg, 1994."},{"key":"424815_CR26","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/3-540-11603-6_5","volume":"142","author":"S. J. Hague","year":"1982","unstructured":"S. J. Hague, S. M. Nugent, and B. Ford. Computer-based documentation for the NAG Library. Lecture Notes in Computer Science, Vol. 142, 1982, pp. 91\u2013127.","journal-title":"Lecture Notes in Computer Science"},{"key":"424815_CR27","volume-title":"Sensitivity Analysis of Dynamic Systems","author":"R. Tomovic","year":"1964","unstructured":"R. Tomovic. Sensitivity Analysis of Dynamic Systems, McGraw-Hill, New York, 1964."},{"key":"424815_CR28","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0022-3565(25)33658-X","volume":"225","author":"S. Toon","year":"1983","unstructured":"S. Toon and M. Rowland. Structure-activity relationships among the barbiturates in the rat. J. Pharmacol. Exp. Ther.\n225:752\u2013763 (1983).","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Journal of Pharmacokinetics and Biopharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1025740909016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1025740909016\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1025740909016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T09:46:22Z","timestamp":1751622382000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1025740909016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["424815"],"URL":"https:\/\/doi.org\/10.1023\/a:1025740909016","relation":{},"ISSN":["0090-466X"],"issn-type":[{"value":"0090-466X","type":"print"}],"subject":[],"published":{"date-parts":[[1997,8]]},"assertion":[{"value":"1 August 1997","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}