{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:11:23Z","timestamp":1785161483980,"version":"3.55.0"},"reference-count":206,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1023\/a:1026080320034","type":"journal-article","created":{"date-parts":[[2003,10,24]],"date-time":"2003-10-24T23:17:50Z","timestamp":1067037470000},"page":"287-305","source":"Crossref","is-referenced-by-count":35,"title":["High altitude hypoxia: An intricate interplay of oxygen responsive macroevents and micromolecules"],"prefix":"10.1007","volume":"253","author":[{"given":"S.","family":"Sarkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.K.","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Selvamurthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5140033_CR1","unstructured":"Ward MP, Milledge JS, West JB: In: High Altitude Medicine and Physiology, 2nd edn. Chapman and Hall Medical, 1995, pp 51-68"},{"key":"5140033_CR2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev.physiol.63.1.259","volume":"63","author":"J Lopez-Barneo","year":"2001","unstructured":"Lopez-Barneo J, Pardal R, Ortega-Saenz P: Cellular mechanism of oxygen sensing. Ann Rev Physiol 63: 259-287, 2001","journal-title":"Ann Rev Physiol"},{"key":"5140033_CR3","first-page":"375","volume-title":"Adaptation Biology and Medicine","author":"IY Malyshev","year":"1999","unstructured":"Malyshev IY, Manukina EB: Stress, adaptation and nitric oxide. In: K.B. Pandolf, N. Takeda, P.K. Singal (eds). Adaptation Biology and Medicine, Vol. 2. Narosa Publishing House, India, 1999, pp 375-392"},{"key":"5140033_CR4","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1152\/jappl.2000.88.6.2287","volume":"88","author":"NR Prabhakar","year":"2000","unstructured":"Prabhakar NR: Oxygen sensing in the carotid body chemoreceptors. J Appl Physiol 88: 2287-2295, 2000","journal-title":"J Appl Physiol"},{"key":"5140033_CR5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ki.1975.130","volume":"8","author":"N Gledhill","year":"1975","unstructured":"Gledhill N, Beirne GJ, Dempsey JA: Renal response to short-term hypocapnia in man. Kidney Int 8: 376-386, 1975","journal-title":"Kidney Int"},{"key":"5140033_CR6","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1152\/jappl.1995.78.2.377","volume":"78","author":"ER Swenson","year":"1995","unstructured":"Swenson ER, Duncan TB, Goldberg SV, Ramirez G, Ahmad S, Schoene RB: Diuretic effect of acute hypoxia in humans: Relationship to hypoxic ventilatory responsiveness and renal hormones. J Appl Physiol 78: 377-383, 1995","journal-title":"J Appl Physiol"},{"key":"5140033_CR7","first-page":"105","volume":"62","author":"P B\u00e4rtsch","year":"1991","unstructured":"B\u00e4rtsch P, Pfluger N, Audetat M, Shaw S, Weidmann P, Vock P, Vetter W, Rennie D, Oelz O: Effects of slow ascent to 4559 M on fluid homeostasis. Aviat Space Environ Med 62: 105-110, 1991","journal-title":"Aviat Space Environ Med"},{"key":"5140033_CR8","first-page":"145","volume":"98","author":"LG Moore","year":"1981","unstructured":"Moore LG, Brewer GJ: Beneficial effect of rightward hemoglobin-oxygen dissociation curve shift for short-term high-altitude adaptation. J Lab Clin Med 98: 145-154, 1981","journal-title":"J Lab Clin Med"},{"key":"5140033_CR9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1152\/jappl.1984.56.1.109","volume":"56","author":"RM Winslow","year":"1984","unstructured":"Winslow RM, Samaja M, West JB: Red cell function at extreme altitude on Mount Everest. J Appl Physiol 56: 109-116, 1984","journal-title":"J Appl Physiol"},{"key":"5140033_CR10","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1098\/rstb.1913.0008","volume":"203","author":"MP Fitzgerald","year":"1913","unstructured":"Fitzgerald MP: The changes in the breathing and the blood at various high altitude. Phil Trans C Proc R Soc Lond ser B 203: 351-371, 1913","journal-title":"Phil Trans C Proc R Soc Lond ser B"},{"key":"5140033_CR11","doi-asserted-by":"crossref","first-page":"R756","DOI":"10.1152\/ajpregu.1994.266.3.R756","volume":"266","author":"JP Richalet","year":"1994","unstructured":"Richalet JP, Souberbielle JC, Antezana AM, D\u00e9chaux M, LeTrong JL, Bienuenu A, Daniel F, Blanchot C, Zittoun J: Control of erythropoiesis in human during prolonged exposure to the altitude of 6542 m. Am J Physiol Regul Intergr Comp Physiol 266: R756-R764, 1994","journal-title":"Am J Physiol Regul Intergr Comp Physiol"},{"key":"5140033_CR12","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1152\/jappl.1996.81.2.636","volume":"81","author":"MN Swaka","year":"1996","unstructured":"Swaka MN, Young AJ, Rock PB, Lyons TP, Boushel R, Freund BJ, Muza SR, Cymerman A, Dennis RC, Pandolf KB, Valeri CR: Altitude acclimatization and blood volume: Effects of exogenous erythrocyte volume expansion. J Appl Physiol 81: 636-642, 1996","journal-title":"J Appl Physiol"},{"key":"5140033_CR13","doi-asserted-by":"crossref","first-page":"11124","DOI":"10.1152\/jappl.1967.22.6.1124","volume":"22","author":"JA Vogel","year":"1967","unstructured":"Vogel JA, Harris CW: Cardiopulmonary responses of resting man during early exposure to high altitude. J Appl Physiol 22: 11124-1128, 1967","journal-title":"J Appl Physiol"},{"issue":"suppl1","key":"5140033_CR14","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1055\/s-2007-1024581","volume":"13","author":"JT Reeves","year":"1992","unstructured":"Reeves JT, Mazzeo RS, Wolfel EE, Young AJ: Increased arterial pressure after acclimatization to 4300 m: Possible role of norepinephrine. Int J Sports Med 13(suppl 1): S18-S21, 1992","journal-title":"Int J Sports Med"},{"key":"5140033_CR15","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1152\/jappl.1999.87.6.2053","volume":"87","author":"IL Kanstrup","year":"1999","unstructured":"Kanstrup IL, Poulsen TD, Hansen JM, Andersen LJ, Bestle MH, Christensen NJ, Olsen NV: Blood pressure and plasma catecholamines in acute and prolonged hypoxia: Effects of local hypothermia. J Appl Physiol 87: 2053-2058, 1999","journal-title":"J Appl Physiol"},{"key":"5140033_CR16","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02281624","volume":"9","author":"M Veglio","year":"1999","unstructured":"Veglio M, Maule S, Cametti G, Cogo A, Lussiana L, Madrigale G, Pecchio O: The effects of exposure to moderate altitude on cardiovascular autonomic function in normal subjects. Clin Auton Res 9: 123-127, 1999","journal-title":"Clin Auton Res"},{"key":"5140033_CR17","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1152\/japplphysiol.00936.2001","volume":"92","author":"MH Bestle","year":"2002","unstructured":"Bestle MH, Olsen NV, Poulsen TD, Roach R, Fogh-Anderson N, Bie P: Prolonged hypobaric hypoxemia attenuates vasopressin secretion and renal response to osmostimulation in men. J Appl Physiol 92: 1911-1922, 2002","journal-title":"J Appl Physiol"},{"key":"5140033_CR18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1440-1681.1996.tb02760.x","volume":"23","author":"JE Brian Jr","year":"1996","unstructured":"Brian JE Jr, Faraci FM, Heistad DD: Recent insights into the regulation of cerebral circulation. Clin Exp Pharmacol Physiol 23: 449-457, 1996","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"5140033_CR19","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1097\/00004647-199808000-00011","volume":"18","author":"A Buck","year":"1998","unstructured":"Buck A, Schirlo C, Jasinksy V, Weber B, Burger C, von Schulthess GK, Koller EA, Pavlicek V: Changes of cerebral blood flow during short-term exposure to normobaric hypoxia. J Cereb Blood Flow Metab 18: 906-910, 1998","journal-title":"J Cereb Blood Flow Metab"},{"key":"5140033_CR20","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/BF01936933","volume":"46","author":"H Hoppeler","year":"1990","unstructured":"Hoppeler H, Howald H, Cerretelli P: Human muscle structure after exposure to extreme altitude. Experientia 46: 1185-1187, 1990","journal-title":"Experientia"},{"key":"5140033_CR21","first-page":"273","volume":"136","author":"U Boutellier","year":"1983","unstructured":"Boutellier U, Howald H, diPrampero PE, Giezendanner D, Cerretelli P: Human muscle adaptation to chronic hypoxia. Prog Clin Biol Res 136: 273-281, 1983","journal-title":"Prog Clin Biol Res"},{"key":"5140033_CR22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1748-1716.1991.tb09176.x","volume":"142","author":"JD McDougall","year":"1991","unstructured":"McDougall JD, Green HJ, Sutton JR, Coates G, Cymerman A, Young P, Houston CS: Operation Everest II: Structural adaptations in skeletal muscle in response to extreme simulated altitude. Acta Physiol Scan 142: 421-427, 1991","journal-title":"Acta Physiol Scan"},{"key":"5140033_CR23","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1152\/jappl.1991.70.2.919","volume":"70","author":"GA Brooks","year":"1991","unstructured":"Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE, Reeves JT: Increased dependence on blood glucose after acclimatization to 4,300 m. J Appl Physiol 70: 919-927, 1991","journal-title":"J Appl Physiol"},{"key":"5140033_CR24","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1152\/jappl.1996.81.4.1762","volume":"81","author":"AC Roberts","year":"1996","unstructured":"Roberts AC, Butterfield GE, Cymerman A, Reeves JT, Mazzeo RS, Wolfel EE, Brooks GA: Acclimatization to 4,300-m altitude decreases reliance on fat as a substrate. J Appl Physiol 81: 1762-1771, 1996","journal-title":"J Appl Physiol"},{"key":"5140033_CR25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1152\/jappl.2001.90.1.17","volume":"90","author":"SL Kennedy","year":"2001","unstructured":"Kennedy SL, Stanley WC, Panchal AR, Mazzeo RS: Alterations in enzymes involved in fat metabolism after acute and chronic altitude exposure. J Appl Physiol 90: 17-22, 2001","journal-title":"J Appl Physiol"},{"key":"5140033_CR26","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1152\/jappl.1992.73.6.2574","volume":"73","author":"PM Young","year":"1992","unstructured":"Young PM, Sutton JR, Green HJ, Reeves JT, Rock PB, Houston CS, Cymerman A: Operation Everest II. Metabolic and hormonal responses to incremental exercise to exhaustion. J Appl Physiol 73: 2574-2579, 1992","journal-title":"J Appl Physiol"},{"key":"5140033_CR27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-4615-2572-1_3","volume":"360","author":"H Acker","year":"1994","unstructured":"Acker H: Oxygen sensing in the carotid body: Ideas and models. Adv Exp Med Biol 360: 21-27, 1994","journal-title":"Adv Exp Med Biol"},{"key":"5140033_CR28","first-page":"1183","volume":"2","author":"S Lahiri","year":"1996","unstructured":"Lahiri S: Peripheral Receptors and their Sensory Neurons in Chronic States of Hypo-and Hyperoxia. Handbook Physiol Env Physiol Sect 4, Vol. 2, 1996, pp 1183-1206","journal-title":"Handbook Physiol Env Physiol Sect 4"},{"key":"5140033_CR29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1046\/j.1365-201X.1997.574342000.x","volume":"159","author":"M Samaja","year":"1997","unstructured":"Samaja M, Mariani C, Prestini A, Cerretelli, P: Acid-base balance and O2 transport at high altitude. Acta Physiol Scand 159: 249-256, 1997","journal-title":"Acta Physiol Scand"},{"key":"5140033_CR30","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.RES.73.6.1100","volume":"73","author":"SL Archer","year":"1993","unstructured":"Archer SL, Huang J, Henry T, Peterson D, Weir EK: A redox-based O2 sensor in rat pulmonary vasculature. Circ Res 73: 1100-1112, 1993","journal-title":"Circ Res"},{"key":"5140033_CR31","first-page":"3","volume-title":"Man at High Altitude","author":"D Heath","year":"1981","unstructured":"Heath D, William DR: Man at High Altitude. Churchill Livingstone, London, 1981, pp 3-23"},{"key":"5140033_CR32","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1152\/jappl.1993.74.1.312","volume":"74","author":"BM Groves","year":"1993","unstructured":"Groves BM, Droma T, Sutton JR, McCullough RG, McCullough RE, Zhuang J, Rapmund G, Sun S, Janes C, Moore LG: Minimal hypoxic pulmonary hypertension in normal Tibetans at 3,658 m. J Appl Physiol 74: 312-318, 1993","journal-title":"J Appl Physiol"},{"key":"5140033_CR33","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","volume":"16","author":"JS Forsythe","year":"1999","unstructured":"Forsythe JS, Hang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL: Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16: 4604-4613, 1999","journal-title":"Mol Cell Biol"},{"key":"5140033_CR34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/1523-1747.ep12286453","volume":"108","author":"M Detmar","year":"1996","unstructured":"Detmar M, Brown LF, Berse B, Jackman RW, Elicker BM, Dvorak HF, Claffey KP: Hypoxia regulates the expression of vascular permeability factor\/vascular endothelial growth factor (VPF\/VEGF) and its receptors in human skin. J Invest Dermatol 108: 263-268, 1996","journal-title":"J Invest Dermatol"},{"key":"5140033_CR35","first-page":"H1948","volume":"267","author":"E Hashimoto","year":"1994","unstructured":"Hashimoto E, Ogita T, Nakaoka T, Matsuoka R, Takao A, Kira Y: Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am J Physiol 267: H1948-H1954, 1994","journal-title":"Am J Physiol"},{"key":"5140033_CR36","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0006-8993(96)00965-1","volume":"737","author":"N Harik","year":"1996","unstructured":"Harik N, Harik SI, Kuo NT, Sakai K, Przybylski RJ, LaManna JC: Time-course and reversibility of the hypoxia-induced alterations in cerebral vascularity and cerebral capillary glucose transporter density. Brain Res 737: 335-338, 1996","journal-title":"Brain Res"},{"key":"5140033_CR37","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1126\/science.2849206","volume":"242","author":"MA Goldberg","year":"1988","unstructured":"Goldberg MA, Dunning SP, Bunn HF: Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science 242: 1412-1415, 1988","journal-title":"Science"},{"key":"5140033_CR38","doi-asserted-by":"crossref","first-page":"9493","DOI":"10.1073\/pnas.93.18.9493","volume":"93","author":"PW Hochachka","year":"1996","unstructured":"Hochachka PW, Buck LT, Doll CJ, Land SC: Unifying theory of hypoxia tolerance: Molecular\/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci USA 93: 9493-9498, 1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"5140033_CR39","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1152\/physrev.1996.76.3.839","volume":"76","author":"HF Bunn","year":"1996","unstructured":"Bunn HF, Poyton RO: Oxygen sensing and molecular adaptation. Physiol Rev 76: 839-885, 1996","journal-title":"Physiol Rev"},{"key":"5140033_CR40","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1152\/jappl.2000.88.5.1880","volume":"88","author":"NS Chandel","year":"2000","unstructured":"Chandel NS, Schumacker PT: Cellular oxygen sensing by mitochondria: Old questions, new insight. J Appl Physiol 88: 1880-1889, 2000","journal-title":"J Appl Physiol"},{"key":"5140033_CR41","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1152\/jappl.2000.88.4.1467","volume":"88","author":"S Lahiri","year":"2000","unstructured":"Lahiri S: Historical perspectives of cellular oxygen sensing and responses to hypoxia. J Appl Physiol 88: 1467-1473, 2000","journal-title":"J Appl Physiol"},{"key":"5140033_CR42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1749-6632.1994.tb55698.x","volume":"718","author":"H Acker","year":"1994","unstructured":"Acker H: Cellular oxygen sensors. Ann NY Acad Sci 718: 3-10, 1994","journal-title":"Ann NY Acad Sci"},{"key":"5140033_CR43","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0891-5849(00)00320-8","volume":"29","author":"RD Jones","year":"2000","unstructured":"Jones RD, Hancock JT, Morice AH: NADPH oxidase: A universal oxygen sensor? Free Radic Biol Med 29: 416-424, 2000","journal-title":"Free Radic Biol Med"},{"key":"5140033_CR44","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0034-5687(00)00160-2","volume":"122","author":"NR Prabhakar","year":"2000","unstructured":"Prabhakar NR, Overholt JL: Cellular mechanisms of oxygen sensing at the carotid body: Heme proteins and ion channels. Respir Physiol 122: 209-221, 2000","journal-title":"Respir Physiol"},{"key":"5140033_CR45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/0-306-46825-5_22","volume":"475","author":"JL Overholt","year":"2000","unstructured":"Overholt JL, Ficker E, Yang T, Shams H, Bright GR, Prabhakr NR: Chemosensing at the carotid body. Involvement of a HERG-like potassium current in glomus cells. Adv Exp Med Biol 475: 241-248, 2000","journal-title":"Adv Exp Med Biol"},{"key":"5140033_CR46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0014-5793(89)81721-1","volume":"256","author":"H Acker","year":"1989","unstructured":"Acker H, Dufau E, Huber J, Sylvester D: Indications to an NADPH oxidase as a possible PO2 sensor in the rat carotid body. FEBS Lett 256: 75-78, 1989","journal-title":"FEBS Lett"},{"key":"5140033_CR47","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood.V87.2.756.bloodjournal872756","volume":"87","author":"RH Wenger","year":"1996","unstructured":"Wenger RH, Marti HH, Schuerer-Maly CC, Kvietikova I, Bauer C, Gassmann M, Maly FE: Hypoxic induction of gene expression in chronic granulomatous disease-derived B-cell lines: Oxygen sensing is independent of the cytochrome b558-containing nicotinamide adenine dinucleotide phosphate oxidase. Blood 87: 756-761, 1996","journal-title":"Blood"},{"key":"5140033_CR48","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0034-5687(01)00310-3","volume":"128","author":"T Porwol","year":"2001","unstructured":"Porwol T, Ehleben W, Brand V, Acker H: Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species. Respir Physiol 128: 331-348, 2001","journal-title":"Respir Physiol"},{"key":"5140033_CR49","doi-asserted-by":"crossref","first-page":"25130","DOI":"10.1074\/jbc.M001914200","volume":"275","author":"NS Chandel","year":"2000","unstructured":"Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriquez AM, Schumacker PJ: Reactive oxygen species generated at mitochondrial complex III stabilize HIF-1\u03b1 during hypoxia: A mechanism of O2 sensing. J Biol Chem 275: 25130-25138, 2000","journal-title":"J Biol Chem"},{"key":"5140033_CR50","doi-asserted-by":"crossref","first-page":"21995","DOI":"10.1074\/jbc.C100177200","volume":"276","author":"V Srinivas","year":"2001","unstructured":"Srinivas V, Leshchinsky I, Sang N, King MP, Minchenko A, Caro J: Oxygen sensing and IIIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J Biol Chem 276: 21995-21998, 2001","journal-title":"J Biol Chem"},{"key":"5140033_CR51","first-page":"202","volume":"15","author":"T Kietzman","year":"2000","unstructured":"Kietzman T, Fandrey J, Acker H: Oxygen radicals as messengers in oxygen-dependent gene expression. News Physiol Sci 15: 202-208, 2000","journal-title":"News Physiol Sci"},{"key":"5140033_CR52","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1023\/A:1014819832003","volume":"67","author":"KT Turpaev","year":"2002","unstructured":"Turpaev KT: Reactive oxygen species and regulation of gene expression. Biochem Mosc 67: 281-292, 2002","journal-title":"Biochem Mosc"},{"key":"5140033_CR53","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1357-4310(97)01198-2","volume":"4","author":"JM Gleadle","year":"1998","unstructured":"Gleadle JM, Ratcliffe PJ: Hypoxia and the regulation of gene expression. Mol Med Today 4: 122-129, 1998","journal-title":"Mol Med Today"},{"key":"5140033_CR54","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0891-5849(00)00343-9","volume":"29","author":"J Genius","year":"2000","unstructured":"Genius J, Fandrey J: Nitric oxide affects the production of reactive oxygen species in hepatoma cells: Implications for the process of oxygen sensing. Free Radic Biol Med 29: 515-521, 2000","journal-title":"Free Radic Biol Med"},{"key":"5140033_CR55","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0034-5687(97)00075-3","volume":"110","author":"D Beitner-Johnson","year":"1997","unstructured":"Beitner-Johnson D, Shull GE, Dedman JR, Millhorn DE: Regulation of gene expression by hypoxia: A molecular approach. Respir Physiol 110: 87-97, 1997","journal-title":"Respir Physiol"},{"key":"5140033_CR56","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1469-7793.1997.293bk.x","volume":"502","author":"L Conforti","year":"1997","unstructured":"Conforti L, Millhorn DE: Selective inhibition of a slow-inactivating voltage-dependent K+ channel in rat PC12 cells by hypoxia. J Physiol 502: 293-305, 1997","journal-title":"J Physiol"},{"key":"5140033_CR57","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ki.1997.73","volume":"51","author":"DE Millhorn","year":"1997","unstructured":"Millhorn DE, Raymond R, Conforti L, Zhu W, Beitner-Johnson D, Filisko T, Genter MB, Kobayashi S, Peng M: Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia. Kidney Int 51: 527-535, 1997","journal-title":"Kidney Int"},{"key":"5140033_CR58","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/ki.1997.74","volume":"51","author":"R Raymond","year":"1997","unstructured":"Raymond R, Millhorn D: Regulation of tyrosine hydroxylase gene expression during hypoxia: Role of Ca2+ and PKC. Kidney Int. 51: 536-541, 1997","journal-title":"Kidney Int"},{"key":"5140033_CR59","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/0-306-46825-5_10","volume":"475","author":"DR Premkumar","year":"2000","unstructured":"Premkumar DR, Adhikary G, Overholt JL, Simonson MS, Cherniack NS, Prabhakar NR: Intracellular pathways linking hypoxia to activation of c-fos and AP-1. Adv Exp Med Biol 475: 101-109, 2000","journal-title":"Adv Exp Med Biol"},{"key":"5140033_CR60","doi-asserted-by":"crossref","first-page":"33709","DOI":"10.1074\/jbc.274.47.33709","volume":"274","author":"PW Conrad","year":"1999","unstructured":"Conrad PW, Freeman TL, Beitner-Johnson D, Millhorn DE: EPAS1 trans-activation during hypoxia requires p42\/p44 MAPK. J Biol Chem 274: 33709-33713, 1999","journal-title":"J Biol Chem"},{"key":"5140033_CR61","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/0-306-46825-5_28","volume":"475","author":"PW Conrad","year":"2000","unstructured":"Conrad PW, Millhorn DE, Beitner-Johnson D: Hypoxia differentially regulates the mitogen-and stress-activated protein kinases. Role of Ca2+\/CaM in the activation of MAPK and p38 gamma. Adv Exp Med Biol 475: 293-302, 2000","journal-title":"Adv Exp Med Biol"},{"key":"5140033_CR62","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1074\/jbc.273.3.1741","volume":"273","author":"H Enslen","year":"1998","unstructured":"Enslen H, Raingeaud J, Davis RJ: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MK K3 and MK K6. J Biol Chem 273: 1741-1748, 1998","journal-title":"J Biol Chem"},{"key":"5140033_CR63","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0898-6568(00)00091-7","volume":"12","author":"PW Conrad","year":"2000","unstructured":"Conrad PW, Millhorn DE, Beitner-Johnson D: Novel regulation of p38gamma by dopamine D2 receptors during hypoxia. Cell Signal 12: 463-467, 2000","journal-title":"Cell Signal"},{"key":"5140033_CR64","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S1096-4959(00)00326-2","volume":"128","author":"PW Conrad","year":"2001","unstructured":"Conrad PW, Conforti L, Kobayashi S, Beitner-Johnson D, Rust RT, Yuan Y, Kim HW, Kim RH, Seta K, Millhorn DE: The molecular basis of O2-sensing and hypoxia tolerance in pheochromocytoma cells. Comp Biochem Physiol B Biochem Mol Biol 128: 187-204, 2001","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"5140033_CR65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0898-6568(00)00128-5","volume":"13","author":"D Beitner-Johnson","year":"2001","unstructured":"Beitner-Johnson D, Rust RT, Hsieh TC, Millhorn DE: Hypoxia activates Akt and induces phosphorylation of GSK-3 in PC12 cells. Cell Signal 13: 23-27, 2001","journal-title":"Cell Signal"},{"key":"5140033_CR66","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1006\/bbrc.1995.2674","volume":"216","author":"GL Wang","year":"1995","unstructured":"Wang GL, Jiang BH, Semenza GL: Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1. Biochem Biophys Res Commun 216: 669-675, 1995","journal-title":"Biochem Biophys Res Commun"},{"key":"5140033_CR67","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/ki.1997.78","volume":"51","author":"S Salceda","year":"1997","unstructured":"Salceda S, Beck I, Srinivas V, Caro J: Complex role of protein phosphorylation in gene activation by hypoxia. Kidney Int 51: 556-559, 1997","journal-title":"Kidney Int"},{"key":"5140033_CR68","doi-asserted-by":"crossref","first-page":"32631","DOI":"10.1074\/jbc.274.46.32631","volume":"274","author":"DE Richard","year":"1999","unstructured":"Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J: p42\/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) and enhance the transcriptional activity of HIF-1. J Biol Chem 274: 32631-32637, 1999","journal-title":"J Biol Chem"},{"key":"5140033_CR69","doi-asserted-by":"crossref","first-page":"21166","DOI":"10.1074\/jbc.M100677200","volume":"276","author":"K Hirota","year":"2001","unstructured":"Hirota K, Semenza GL: Rac1 activity is required for the activation of hypoxia-inducible factor 1. J Biol Chem 276: 21166-21172, 2001","journal-title":"J Biol Chem"},{"key":"5140033_CR70","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/375577a0","volume":"375","author":"D Mukhopadhyay","year":"1995","unstructured":"Mukhopadhyay D, Tsiokas L, Zhou X-M, Foster D, Brugge JS, Sukhatme VP: Hypoxic induction of human vascular epithelial growth factor expression through c-Src expression. Nature Lond 375: 577-581, 1995","journal-title":"Nature Lond"},{"key":"5140033_CR71","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/01.RES.0000024412.24491.CA","volume":"91","author":"F Jung","year":"2002","unstructured":"Jung F, Haendeler J, Hoffmann J, Reissner A, Dernbach E, Zeiher AM, Dimmeler S: Hypoxic induction of the hypoxia-inducible factor is mediated via the adaptor protein She in endothelial cells. Circ Res 91: 38-45, 2002","journal-title":"Circ Res"},{"key":"5140033_CR72","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1074\/jbc.271.2.611","volume":"271","author":"D Stapleton","year":"1996","unstructured":"Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE: Mammalian AMP-activated protein kinase subfamily. J Biol Chem 271: 611-614, 1996","journal-title":"J Biol Chem"},{"key":"5140033_CR73","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/abbi.2000.1935","volume":"380","author":"W Abbud","year":"2000","unstructured":"Abbud W, Habinowski S, Zhang JZ, Kendrew J, Elkairi FS, Kemp BE, Witters LA, Ismail-Beigi F: Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport. Arch Biochem Biophys 380: 347-352, 2000","journal-title":"Arch Biochem Biophys"},{"key":"5140033_CR74","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1126\/science.1063518","volume":"294","author":"PB Dennis","year":"2001","unstructured":"Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G: Mammalian TOR: Ahomeostatic ATP sensor. Science 294: 1102-1105, 2001","journal-title":"Science"},{"key":"5140033_CR75","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1096\/fj.01-0658com","volume":"16","author":"R Humar","year":"2002","unstructured":"Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ: Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling. FASEB J 16: 771-80, 2002","journal-title":"FASEB J"},{"key":"5140033_CR76","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0021-9258(17)42415-X","volume":"269","author":"MF Czyzyk-Krzeska","year":"1994","unstructured":"Czyzyk-Krzeska MF, Furnari BA, Lawson EE, Millhorn DE: Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. J Biol Chem 269: 760-764, 1994","journal-title":"J Biol Chem"},{"key":"5140033_CR77","doi-asserted-by":"crossref","first-page":"23774","DOI":"10.1074\/jbc.270.40.23774","volume":"270","author":"ML Norris","year":"1995","unstructured":"Norris ML, Millhorn DE: Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem 270: 23774-23779, 1995","journal-title":"J Biol Chem"},{"key":"5140033_CR78","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0169-328X(99)00321-6","volume":"75","author":"KA Huey","year":"2000","unstructured":"Huey KA, Powell FL: Time-dependent changes in dopamine D(2)-receptor mRNA in the arterial chemoreflex pathway with chronic hypoxia. Brain Res Mol Brain Res 75: 264-270, 2000","journal-title":"Brain Res Mol Brain Res"},{"key":"5140033_CR79","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0034-5687(00)00113-4","volume":"121","author":"J Chen","year":"2000","unstructured":"Chen J, He L, Dinger B, Fidone S: Cellular mechanisms involved in rabbit carotid body excitation elicited by endothelin. Respir Physiol 121: 13-23, 2000","journal-title":"Respir Physiol"},{"key":"5140033_CR80","first-page":"3739","volume":"10","author":"M Paciga","year":"1999","unstructured":"Paciga M, Vollmer C, Nurse, C: Role of ET-1 in hypoxia-induced mitosis of cultured rat carotid body chemoreceptors. Neuro Report 10: 3739-3744, 1999","journal-title":"Neuro Report"},{"key":"5140033_CR81","first-page":"1474","volume":"88","author":"GL Semenza","year":"2000","unstructured":"Semenza GL: HIF-1: Mediator of physiological and pathophysiological responses to hypoxia. J Appl Biol 88: 1474-1480, 2000","journal-title":"J Appl Biol"},{"key":"5140033_CR82","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1172\/JCI114759","volume":"86","author":"S Kourembanas","year":"1990","unstructured":"Kourembanas S, Hannan RL, Faller DV: Oxygen regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J Clin Invest 86: 670-674, 1990","journal-title":"J Clin Invest"},{"key":"5140033_CR83","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1172\/JCI116122","volume":"90","author":"R Shreeniwas","year":"1992","unstructured":"Shreeniwas R, Koga S, Karakurum M, Pinsky D, Kaiser E, Brett J, Wolitzky BA, Norton C, Plocinski J, Benjamin W et al.: Hypoxia-mediated induction of endothelial cell interleukin-1 alpha. An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. J Clin Invest 90: 2333-2339, 1992","journal-title":"J Clin Invest"},{"key":"5140033_CR84","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1172\/JCI117135","volume":"93","author":"M Karakurum","year":"1994","unstructured":"Karakurum M, Shreeniwas R, Chen J, Pinsky D, Yan SD, Anderson M, Sunouchi K, Major J, Hamilton T, Kuwabara K et al.: Hypoxic induction of interleukin-8 gene expression in human endothelial cells. J Clin Invest 93: 1564-1570, 1994","journal-title":"J Clin Invest"},{"key":"5140033_CR85","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.90.9.4304","volume":"90","author":"GL Wang","year":"1993","unstructured":"Wang GL, Semenza GL: General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA 90: 4304-4308, 1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"5140033_CR86","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1089\/152702901750265251","volume":"2","author":"J Caro","year":"2001","unstructured":"Caro J: Hypoxia regulation of gene transcription. High Alt Med Biol 2: 145-154, 2001","journal-title":"High Alt Med Biol"},{"key":"5140033_CR87","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/ki.1997.77","volume":"51","author":"GL Semenza","year":"1997","unstructured":"Semenza GL, Agani F, Booth G, Forsythe J, Iyer N, Jiang BH, Leung S, Roe R, Wiener C, Yu A: Structural and functional analysis of hypoxia-inducible factor I. Kidney Int 51: 553-555, 1997","journal-title":"Kidney Int"},{"key":"5140033_CR88","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/383344a0","volume":"383","author":"S Bhattacharya","year":"1996","unstructured":"Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, Livingston DM: Cooperation of Stat2 and p300\/CBP in signaling induced by interferon-alpha. Nature Lond 383: 344-347, 1996","journal-title":"Nature Lond"},{"key":"5140033_CR89","doi-asserted-by":"crossref","first-page":"12969","DOI":"10.1073\/pnas.93.23.12969","volume":"93","author":"Z Arany","year":"1996","unstructured":"Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, Livingston DM: An essential role for p300\/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA 93: 12969-12973, 1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"5140033_CR90","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1093\/emboj\/17.22.6573","volume":"17","author":"PJ Kallio","year":"1998","unstructured":"Kallio PJ, Okamoto K, O'Brien S, Carrero P, Makino Y, Tanaka H, Poellinger L: Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP\/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J 17: 6573-6586, 1998","journal-title":"EMBO J"},{"key":"5140033_CR91","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1128\/MCB.20.1.402-415.2000","volume":"20","author":"P Carrero","year":"2000","unstructured":"Carrero P, Okamoto K, Coumailleau P, O'Brien S, Tanaka H, Poellinger L: Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1 alpha. Mol Cell Biol 20: 402-415, 2000","journal-title":"Mol Cell Biol"},{"key":"5140033_CR92","first-page":"205","volume":"7","author":"YZ Gu","year":"1998","unstructured":"Gu YZ, Moran SM, Hogenesch JB, Wartman L, Bradfield CA: Molecular characterization and chromosomal localization of a third \u03b1-class hypoxia-inducible factor subunit, HIF-3\u03b1. Gene Exp 7: 205-213, 1998","journal-title":"Gene Exp"},{"key":"5140033_CR93","doi-asserted-by":"crossref","first-page":"22642","DOI":"10.1074\/jbc.272.36.22642","volume":"272","author":"S Salceda","year":"1997","unstructured":"Salceda S, Caro J: Hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1) protein is rapidly degraded by the ubiquitin-proteosome system under normoxic conditions: Its stabilization by hypoxia depends on redox-induced changes. J Biol Chem 272: 22642-22647, 1997","journal-title":"J Biol Chem"},{"key":"5140033_CR94","doi-asserted-by":"crossref","first-page":"7987","DOI":"10.1073\/pnas.95.14.7987","volume":"95","author":"LE Huang","year":"1998","unstructured":"Huang LE, Gu J, Schau M, Bunn HE: Regulation of hypoxia-inducible factor 1\u03b1 is mediated by an O2-dependent degradation domain via the ubiquitin-proteosome pathway. Proc Natl Acad Sci USA 95: 7987-7992, 1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"5140033_CR95","doi-asserted-by":"crossref","first-page":"6519","DOI":"10.1074\/jbc.274.10.6519","volume":"274","author":"PJ Kallio","year":"1999","unstructured":"Kallio PJ, Wilson WJ, O'Brien S, Makino Y, Poellinger L: Regulation of the hypoxia-inducible transcription factor 1\u03b1 by the ubiquitin-proteosome pathway. J Biol Chem 274: 6519-6525, 1999","journal-title":"J Biol Chem"},{"key":"5140033_CR96","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","volume":"292","author":"M Ivan","year":"2001","unstructured":"Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaclin WG Jr: HIF alpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing. Science 292: 464-468, 2001","journal-title":"Science"},{"key":"5140033_CR97","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","volume":"292","author":"P Jaakkola","year":"2001","unstructured":"Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, Kriegsheim AV, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ: Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292: 468-472, 2001","journal-title":"Science"},{"key":"5140033_CR98","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0092-8674(88)90076-1","volume":"54","author":"R Chiu","year":"1988","unstructured":"Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M: The c-fos protein interacts with c-jun\/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54: 541-552, 1988","journal-title":"Cell"},{"key":"5140033_CR99","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0092-8674(88)90024-4","volume":"55","author":"T Curran","year":"1988","unstructured":"Curran T, Franza BR Jr: Fos and jun: The AP-1 connection. Cell 55: 395-397, 1988","journal-title":"Cell"},{"key":"5140033_CR100","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1101\/gad.3.2.173","volume":"3","author":"DR Cohen","year":"1989","unstructured":"Cohen DR, Ferreira CP, Grentz R, Franza BR Jr, Curran T: The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with jun: Transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev 3: 173-184, 1989","journal-title":"Genes Dev"},{"key":"5140033_CR101","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1073\/pnas.88.9.3720","volume":"88","author":"T Hai","year":"1991","unstructured":"Hai T, Curran T: Cross-family dimerization of transcription factors fos\/jun and ATF\/CREB alters DNA binding specificity. Proc Natl Acad Sci USA 88: 3720-3724, 1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"5140033_CR102","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0092-8674(88)90147-X","volume":"55","author":"TD Halazonetis","year":"1988","unstructured":"Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P: c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 55: 917-924, 1988","journal-title":"Cell"},{"key":"5140033_CR103","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/341243a0","volume":"341","author":"M Neuberg","year":"1989","unstructured":"Neuberg M, Adamkiewicz J, Hunter JB, Muller R: A Fos protein containing the Jun leucine zipper forms a homodimer which binds to the AP1 binding site. Nature Lond 341: 243-245, 1989","journal-title":"Nature Lond"},{"key":"5140033_CR104","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1042\/bj3600599","volume":"360","author":"L Steinmuller","year":"2001","unstructured":"Steinmuller L, Cibelli G, Moll JR, Vinson C, Thiel G: Regulation and composition of activator protein 1 (AP-1) transcription factors controlling collagenase and c-Jun promoter activities. Biochem J 360: 599-607, 2001","journal-title":"Biochem J"},{"key":"5140033_CR105","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1126\/science.2118682","volume":"249","author":"C Abate","year":"1990","unstructured":"Abate C, Patel L, Rauscher FJ, Curran T: Redox regulation of fos and jun DNA-binding activity in vitro. Science 249: 1157-1161, 1990","journal-title":"Science"},{"key":"5140033_CR106","doi-asserted-by":"crossref","first-page":"11463","DOI":"10.1074\/jbc.270.19.11463","volume":"270","author":"SF Yan","year":"1995","unstructured":"Yan SF, Tritto I, Pinsky D, Liao H, Huang J, Fuller G, Brett J, May L, Stern D: Induction of interleukin 6 (IL-6) by hypoxia in vascular cells: Central role of the binding site for nuclear factor-IL6. J Biol Chem 270: 11463-11471, 1995","journal-title":"J Biol Chem"},{"key":"5140033_CR107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4889(00)00041-0","volume":"1497","author":"C Michiels","year":"2000","unstructured":"Michiels C, Arnould T, Remacle J: Endothelial cell responses to hypoxia: Initiation of a cascade of cellular interactions. Biochim Biophys Acta 1497: 1-10, 2000","journal-title":"Biochim Biophys Acta"},{"key":"5140033_CR108","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1152\/jappl.2000.88.6.2303","volume":"88","author":"SF Yan","year":"2000","unstructured":"Yan SF, Lu J, Xu L, Zou YS, Tongers J, Kisiel W, Mackman N, Pinsky DJ, Stern DM: Pulmonary expression of early growth response-1: Biphasic time course and effect of oxygen concentration. J Appl Physiol 88: 2303-2309, 2000","journal-title":"J Appl Physiol"},{"key":"5140033_CR109","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1074\/jbc.271.5.2731","volume":"271","author":"MZ Cui","year":"1996","unstructured":"Cui MZ, Parry GC, Oeth P, Larson H, Smith M, Huang RP, Adamson ED, Mackman N: Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1. J Biol Chem 271: 2731-2739, 1996","journal-title":"J Biol Chem"},{"key":"5140033_CR110","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1073\/pnas.95.14.8298","volume":"95","author":"SF Yan","year":"1998","unstructured":"Yan SF, Zou YS, Gao Y, Zhai C, Mackman N, Lee SL, Milbrandt J, Pinsky D, Kisiel W, Stern D: Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia. Proc Natl Acad Sci USA 95: 8298-8303, 1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"5140033_CR111","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1172\/JCI119337","volume":"99","author":"CA Lawson","year":"1997","unstructured":"Lawson CA, Yan SD, Yan SF, Liao H, Zhou YS, Sobel J, Kisiel W, Stern DM, Pinsky DJ: Monocytes and tissue factor promote thrombosis in a murine model of oxygen deprivation. J Clin Invest 99: 1729-1738, 1997","journal-title":"J Clin Invest"},{"key":"5140033_CR112","doi-asserted-by":"crossref","first-page":"11921","DOI":"10.1074\/jbc.275.16.11921","volume":"275","author":"SF Yan","year":"2000","unstructured":"Yan SF, Lu J, Zou YS, Kisiel W, Mackman N, Leitges M, Steinberg S, Pinsky D, Stern D: Protein kinase C-\u03b2 and oxygen deprivation: A novel EGR-1-dependent pathway for fibrin deposition in hypoxemic vasculature. J Biol Chem 275: 11921-11928, 2000","journal-title":"J Biol Chem"},{"key":"5140033_CR113","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/rr27","volume":"1","author":"GL Semenza","year":"2000","unstructured":"Semenza GL: Oxygen-regulated transcription factors and their role in pulmonary disease. Respir Res 1: 159-162, 2000","journal-title":"Respir Res"},{"key":"5140033_CR114","first-page":"5989","volume":"59","author":"SK Bae","year":"1999","unstructured":"Bae SK, Bae MH, Ahn MY, Son MJ, Lee YM, Bae MK, Lee OH, Park BC, Kim KW: Egr-1 mediates transcriptional activation of IGF-II gene in response to hypoxia. Cancer Res 59: 5989-5994, 1999","journal-title":"Cancer Res"},{"key":"5140033_CR115","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/152702901750265260","volume":"2","author":"M Samaja","year":"2001","unstructured":"Samaja M: Hypoxia-dependent protein expression: Erythropoietin. High Alt Med Biol 2: 155-163, 2001","journal-title":"High Alt Med Biol"},{"key":"5140033_CR116","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-201x.2002.00940.x","volume":"174","author":"B Berglund","year":"2002","unstructured":"Berglund B, Gennser M, Ornhagen H, Ostberg C, Wide L: Erythropoietin concentrations during 10 days of normobaric hypoxia under controlled environmental circumstances. Acta Physiol Scand 174: 225-229, 2002","journal-title":"Acta Physiol Scand"},{"key":"5140033_CR117","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/ndt\/17.3.356","volume":"17","author":"MS Weisener","year":"2002","unstructured":"Weisener MS, Eckardt KU: Erythropoietin, tumors and the von Hippel-Lindau gene: Towards identification of mechanisms and dysfunction of oxygen sensing. Nephrol Dial Transplant 17: 356-359, 2002","journal-title":"Nephrol Dial Transplant"},{"key":"5140033_CR118","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1242\/jeb.201.8.1197","volume":"201","author":"HF Bunn","year":"1998","unstructured":"Bunn HF, Gu J, Huang LE, Park J-W, Zhu H: Erythropoietin: A model system for studying oxygen-dependent gene regulation. J Exp Biol 201: 1197-1201, 1998","journal-title":"J Exp Biol"},{"key":"5140033_CR119","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1128\/MCB.15.4.2135","volume":"15","author":"DL Galson","year":"1995","unstructured":"Galson DL, Tuschiya T, Tendler DS, Huang LE, Ren Y, Ogura T, Bunn HF: The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3\/COUP-TF1. Mol Cell Biol 15: 2135-2144, 1995","journal-title":"Mol Cell Biol"},{"key":"5140033_CR120","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s004240050351","volume":"433","author":"B Gess","year":"1997","unstructured":"Gess B, Wolf K, Kurtz A: Lack of control by immediate early response genes in the oxygen regulation of erythropoietin gene expression. Pfl\u00fcgers Arch 433: 827-831, 1997","journal-title":"Pfl\u00fcgers Arch"},{"key":"5140033_CR121","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1046\/j.1523-1755.1999.00610.x","volume":"56","author":"N Ferrara","year":"1999","unstructured":"Ferrara N: Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 56: 794-814, 1999","journal-title":"Kidney Int"},{"key":"5140033_CR122","doi-asserted-by":"crossref","first-page":"11947","DOI":"10.1016\/S0021-9258(18)99049-6","volume":"266","author":"E Tisher","year":"1991","unstructured":"Tisher E, Mitchell R, Hartmann T, Silva M, Gospodarowicz D, Fiddes J, Abraham J: The human gene for vascular endothelial growth factor. J Biol Chem 266: 11947-11954, 1991","journal-title":"J Biol Chem"},{"key":"5140033_CR123","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1074\/jbc.270.22.13333","volume":"270","author":"AP Levy","year":"1995","unstructured":"Levy AP, Levy NS, Wegner S, Goldberg MA: Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem 270: 13333-13340, 1995","journal-title":"J Biol Chem"},{"key":"5140033_CR124","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1006\/bbrc.1995.1356","volume":"208","author":"G Finkenzeller","year":"1995","unstructured":"Finkenzeller G, Technau A, Marme D: Hypoxia-induced transcription of the vascular endothelial growth factor gene is independent of functional AP-1 transcription factor. Biochem Biophys Res Commun 208: 432-439, 1995","journal-title":"Biochem Biophys Res Commun"},{"key":"5140033_CR125","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1016\/S0021-9258(17)41787-X","volume":"260","author":"MA Goldberg","year":"1994","unstructured":"Goldberg MA, Schneider TJ: Similarities between the oxygen sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 260: 4355-4359, 1994","journal-title":"J Biol Chem"},{"key":"5140033_CR126","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1210\/edrv.18.1.0287","volume":"18","author":"N Ferrara","year":"1997","unstructured":"Ferrara N, Davies-Smyth T: The biology of vascular endothelial growth factor. Endoer Rev 18: 4-25, 1997","journal-title":"Endoer Rev"},{"key":"5140033_CR127","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0167-4781(97)00052-3","volume":"1352","author":"NS Levy","year":"1997","unstructured":"Levy NS, Goldberg MA, Levy AP: Sequencing of the human vascular endothelial growth factor (VEGF) 3\u2032 untranslated region (UTR): Conservation of five hypoxia-inducible RNA-protein binding sites. Biochim Biophys Acta 1352: 167-173, 1997","journal-title":"Biochim Biophys Acta"},{"key":"5140033_CR128","doi-asserted-by":"crossref","first-page":"13635","DOI":"10.1074\/jbc.M108703200","volume":"277","author":"I Goldberg-Cohen","year":"2002","unstructured":"Goldberg-Cohen I, Furneauxb H, Levy AP: A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR. J Biol Chem 277: 13635-13640, 2002","journal-title":"J Biol Chem"},{"key":"5140033_CR129","doi-asserted-by":"crossref","first-page":"23774","DOI":"10.1074\/jbc.270.40.23774","volume":"270","author":"ML Norris","year":"1995","unstructured":"Norris ML, Millhorn DE: Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem 270: 23774-23779, 1995","journal-title":"J Biol Chem"},{"key":"5140033_CR130","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1006\/bbrc.1998.8639","volume":"246","author":"AB Scandurro","year":"1998","unstructured":"Scandurro AB, Beckman BS: Common proteins bind mRNAs encoding erythropoietin, tyrosine hydroxylase, and vascular endothelial growth factor. Biochem Biophys Res Commun 246: 436-440, 1998","journal-title":"Biochem Biophys Res Commun"},{"key":"5140033_CR131","first-page":"1347","volume":"79","author":"K Nakanishi","year":"1999","unstructured":"Nakanishi K, Tajima F, Nakata Y, Osada H, Tachibana S, Kawai T, Torikata C, Suga T, Takishima K, Aurues T, Ikeda T: Expression of endothelin-1 in rats developing hypobaric hypoxia-induced pulmonary hypertension. Lab Invest 79: 1347-1357, 1999","journal-title":"Lab Invest"},{"key":"5140033_CR132","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1172\/JCI115367","volume":"88","author":"S Kourembanas","year":"1991","unstructured":"Kourembanas S, Marsden PA, McQuillan LP, Faller DV: Hypoxia induces endothelial gene expression and secretion in cultured human endothelium. J Clin Invest 88: 1054-1057, 1991","journal-title":"J Clin Invest"},{"key":"5140033_CR133","first-page":"R1260","volume":"263","author":"TS Elton","year":"1992","unstructured":"Elton TS, Oparil S, Taylor GR, Hicks PH, Yang RH, Jin H, Chen YF: Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am J Physiol 263: R1260-R1264, 1992","journal-title":"Am J Physiol"},{"key":"5140033_CR134","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/A:1007042729486","volume":"208","author":"A Minchenko","year":"2000","unstructured":"Minchenko A, Caro J: Regulation of endothelin-1 gene expression in human microvascular endothelial cells by hypoxia and cobalt: Role of hypoxia responsive element. Mol Cell Biochem 208: 53-62, 2000","journal-title":"Mol Cell Biochem"},{"key":"5140033_CR135","doi-asserted-by":"crossref","first-page":"12645","DOI":"10.1074\/jbc.M011344200","volume":"276","author":"K Yamashita","year":"2001","unstructured":"Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA: Molecular regulation of the endothelin-1 gene by hypoxia contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, and p300\/CBP. J Biol Chem 276: 12645-12653, 2001","journal-title":"J Biol Chem"},{"key":"5140033_CR136","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1074\/jbc.272.9.5555","volume":"272","author":"A Behrooz","year":"1997","unstructured":"Behrooz A, Ismail-Beigi F: Dual control of Glut-1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation. J Biol Chem 272: 5555-5562, 1997","journal-title":"J Biol Chem"},{"key":"5140033_CR137","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1046\/j.0022-3042.2001.00756.x","volume":"80","author":"RJ Boado","year":"2002","unstructured":"Boado RJ, Pardridge WM: Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element. J Neurochem 80: 552-554, 2002","journal-title":"J Neurochem"},{"key":"5140033_CR138","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1111\/j.1471-4159.1993.tb03516.x","volume":"60","author":"RJ Boado","year":"1993","unstructured":"Boado RJ, Pardridge WM: Glucose deprivation causes post-transcriptional enhancement of brain capillary endothelial glucose transporter gene expression via GLUT1 mRNA stabilization. J Neurochem 60: 2290-2296, 1993","journal-title":"J Neurochem"},{"key":"5140033_CR139","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1042\/bj3130809","volume":"313","author":"BL Ebert","year":"1996","unstructured":"Ebert BL, Gleadle JM, O'Rourke JF, Bartlett SM, Poulton J, Ratcliffe PJ: Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: Similarities with the regulation of erythropoietin. Biochem J 313: 809-814, 1996","journal-title":"Biochem J"},{"key":"5140033_CR140","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1073\/pnas.91.14.6496","volume":"91","author":"JD Firth","year":"1994","unstructured":"Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ: Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3\u2032 enhancer. Proc Natl Acad Sci USA 91: 6496-6500, 1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"5140033_CR141","doi-asserted-by":"crossref","first-page":"23757","DOI":"10.1016\/S0021-9258(17)31580-6","volume":"269","author":"GL Semenza","year":"1994","unstructured":"Semenza GL, Roth PH, Fang HM, Wang GL: Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 269: 23757-23763, 1994","journal-title":"J Biol Chem"},{"key":"5140033_CR142","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1432-1033.1991.tb16061.x","volume":"198","author":"J Hellkamp","year":"1991","unstructured":"Hellkamp J, Christ B, Bastian H, Jungermann K: Modulation by oxygen of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene in rat hepatocyte cultures. Eur J Biochem 198: 635-639, 1991","journal-title":"Eur J Biochem"},{"key":"5140033_CR143","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/978-1-4612-1990-3_8","volume-title":"Introduction to Cellular Signal Transduction","author":"JL Garvin","year":"1999","unstructured":"Garvin JL: Nitric oxide: Synthesis and intracellular actions. In: A. Sitaramayya (ed). Introduction to Cellular Signal Transduction. Birkh\u00e4user, Boston, 1999, pp 177-212"},{"key":"5140033_CR144","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1096\/fasebj.12.10.773","volume":"12","author":"U Forstermann","year":"1998","unstructured":"Forstermann U, Boissel JP, Kleinert H: Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J 12: 773-790, 1998","journal-title":"FASEB J"},{"key":"5140033_CR145","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-3940(95)11492-F","volume":"190","author":"A Trzebski","year":"1995","unstructured":"Trzebski A, Sato Y, Suzuki A, Sato A: Inhibition of nitric oxide synthesis potentiates the responsiveness of carotid chemoreceptors to systemic hypoxia in the rat. Neurosci Lett 190: 29-32, 1995","journal-title":"Neurosci Lett"},{"key":"5140033_CR146","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1152\/jappl.1996.81.5.2068","volume":"81","author":"D Gozal","year":"1996","unstructured":"Gozal D, Torres JE, Gozal YM, Littwin SM: Effect of nitric oxide synthase inhibition on cardiorespiratory responses in the conscious rat. J Appl Physiol 81: 2068-2077, 1996","journal-title":"J Appl Physiol"},{"key":"5140033_CR147","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1165\/ajrcmb.13.2.7542896","volume":"13","author":"PW Shaul","year":"1995","unstructured":"Shaul PW, North AJ, Brannon TS, Ujiie K, Wells LB, Nisen PA, Lowenstein CJ, Snyder SH, Star RA: Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung. Am J Respir Cell Mol Biol 13: 167-174, 1995","journal-title":"Am J Respir Cell Mol Biol"},{"key":"5140033_CR148","first-page":"L667","volume":"267","author":"C Xue","year":"1994","unstructured":"Xue C, Rengasamy A, Le Cras TD, Koberna PA, Dailey GC, Johns RA: Distribution of nitric oxide synthase (NOS) in normoxic vs. hypoxic rat lung: Upregulation of NOS by chronic hypoxia. Am J Physiol 267: L667-L678, 1994","journal-title":"Am J Physiol"},{"key":"5140033_CR149","first-page":"L164","volume":"270","author":"TD LeCras","year":"1996","unstructured":"LeCras TD, Xue C, Rengasamy A: Chronic hypoxia upregulates endothelial and inducible NO synthase gene and protein expression in rat lung. Am J Physiol 270: L164-L170, 1996","journal-title":"Am J Physiol"},{"key":"5140033_CR150","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1096\/fasebj.12.10.773","volume":"12","author":"U Forstermann","year":"1998","unstructured":"Forstermann U, Boissel JP, Kleinert H: Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J 12: 773-790, 1998","journal-title":"FASEB J"},{"key":"5140033_CR151","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/ki.1994.318","volume":"46","author":"MG Mohaupt","year":"1994","unstructured":"Mohaupt MG, Elzie JL, Ahn KY, Clapp WL, Wilcox CS, Kone BL: Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidneys. Kidney Int 46: 653-665, 1994","journal-title":"Kidney Int"},{"key":"5140033_CR152","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0006-8993(93)90132-7","volume":"625","author":"NR Prabhakar","year":"1993","unstructured":"Prabhakar NR, Kumar GK, Chang CH, Agani FH, Haxhiu MA: Nitric oxide in the sensory function of the carotid body. Brain Res 625: 16-22, 1993","journal-title":"Brain Res"},{"key":"5140033_CR153","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0165-1838(95)00006-J","volume":"54","author":"PA Grimes","year":"1995","unstructured":"Grimes PA, Mokashi A, Stone RA, Lahiri S: Nitric oxide synthase in autonomic innervation of the carotid body. J Auton Nerv Syst 54: 80-86, 1995","journal-title":"J Auton Nerv Syst"},{"key":"5140033_CR154","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0306-4522(92)90184-4","volume":"46","author":"SR Vincent","year":"1992","unstructured":"Vincent SR, Kimura H: Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience 46: 755-784, 1992","journal-title":"Neuroscience"},{"key":"5140033_CR155","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0034-5687(95)00020-E","volume":"101","author":"MA Haxhui","year":"1995","unstructured":"Haxhui MA, Chang CH, Dreshraj IA, Erokwu B, Prabhakar NR, Cherniack NS: Nitric oxide and ventilatory response to hypoxia. Respir Physiol 101: 257-266, 1995","journal-title":"Respir Physiol"},{"key":"5140033_CR156","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/978-1-4615-5891-0_53","volume":"410","author":"NR Prabhakar","year":"1996","unstructured":"Prabhakar NR, Rao S, Premkumar D, Pieramici SF, Kumar GK, Kalaria RK: Regulation of neuronal nitric oxide synthase gene expression by hypoxia. Role of nitric oxide in respiratory adaptation to low pO2. Adv Exp Med Biol 410: 345-348, 1996","journal-title":"Adv Exp Med Biol"},{"key":"5140033_CR157","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1469-7793.1998.273bi.x","volume":"511","author":"DD Kline","year":"1998","unstructured":"Kline DD, Yang T, Huang PL, Prabhakar NR: Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J Physiol 511: 273-287, 1998","journal-title":"J Physiol"},{"key":"5140033_CR158","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1152\/ajpregu.1993.265.1.R14","volume":"265","author":"SW Mifflin","year":"1993","unstructured":"Mifflin SW: Inhibition of chemoreceptor inputs to nucleus of tractus solitarius neurons during baroreceptor stimulation. Am J Physiol Regulatory Integrative Comp Physiol 265: R14-R20, 1993","journal-title":"Am J Physiol Regulatory Integrative Comp Physiol"},{"key":"5140033_CR159","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1146\/annurev.ph.57.030195.004011","volume":"57","author":"JG Umans","year":"1995","unstructured":"Umans JG, Levi R: Nitric oxide in the regulation of blood flow and arterial pressure. Ann Rev Physiol 57: 771-790, 1995","journal-title":"Ann Rev Physiol"},{"key":"5140033_CR160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1152\/physrev.1998.78.1.53","volume":"78","author":"FM Faraci","year":"1998","unstructured":"Faraci FM, Heistad DD: Regulation of the cerebral circulation: Role of endothelium and potassium channels. Physiol Rev 78: 53-97, 1998","journal-title":"Physiol Rev"},{"key":"5140033_CR161","first-page":"161","volume":"2","author":"OB Paulson","year":"1990","unstructured":"Paulson OB, Strandgaard S, Edvinsson I: Cerebral autoregulation. Cerebrovasc Brain Metab Rev 2: 161-192, 1990","journal-title":"Cerebrovasc Brain Metab Rev"},{"key":"5140033_CR162","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1088\/0967-3334\/19\/3\/001","volume":"19","author":"RB Panerai","year":"1998","unstructured":"Panerai RB: Assessment of cerebral pressure autoregulation in humans: A review of measurement methods. Physiol Meas 19: 305-338, 1998","journal-title":"Physiol Meas"},{"key":"5140033_CR163","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1152\/japplphysiol.00616.2001","volume":"92","author":"AHM Van Mil","year":"2002","unstructured":"Van Mil AHM, Spilt A, Buchem MAV, Bollen ELEM, Teppema L, Westendorp RGJ, Blauw J: Nitric oxide mediated hypoxia-induced cerebral vasodilation in humans. J Appl Physiol 92: 962-966, 2002","journal-title":"J Appl Physiol"},{"key":"5140033_CR164","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1161\/01.ATV.17.11.3147","volume":"17","author":"XL Wang","year":"1997","unstructured":"Wang XL, Mahaney MC, Sim AS et al.: Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscl Thromb Vasc Biol 17: 3147-3153, 1997","journal-title":"Arterioscl Thromb Vasc Biol"},{"key":"5140033_CR165","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1152\/jappl.2000.88.4.1496","volume":"88","author":"DD Kline","year":"2000","unstructured":"Kline DD, Yang T, Premkumar DRD, Thomas AJ, Prabhakar NR: Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3. J Appl Physiol 88: 1496-1508, 2000","journal-title":"J Appl Physiol"},{"key":"5140033_CR166","first-page":"L212","volume":"274","author":"LA Palmer","year":"1998","unstructured":"Palmer LA, Semenza GL, Stoler MH, Johns RA: Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am J Physiol 274: L212-L219, 1998","journal-title":"Am J Physiol"},{"key":"5140033_CR167","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1093\/nar\/23.22.4542","volume":"23","author":"I Kvietikova","year":"1995","unstructured":"Kvietikova I, Wenger RH, Marti HH, Gassmann M: The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1) DNA recognition site. Nucl Acids Res 23: 4542-4550, 1995","journal-title":"Nucl Acids Res"},{"key":"5140033_CR168","doi-asserted-by":"crossref","first-page":"39805","DOI":"10.1074\/jbc.M107689200","volume":"276","author":"KB Sandau","year":"2001","unstructured":"Sandau KB, Zhou J, Kietzmann T, Brune B. Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide. J Biol Chem 276: 39805-139801, 2001","journal-title":"J Biol Chem"},{"key":"5140033_CR169","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.cb.11.110195.002221","volume":"11","author":"SR Jaffrey","year":"1995","unstructured":"Jaffrey SR, Snyder SH: Nitric oxide: A neural messenger. Ann Rev Cell Dev Biol 11: 417-440, 1995","journal-title":"Ann Rev Cell Dev Biol"},{"key":"5140033_CR170","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/10715769309145868","volume":"18","author":"RE Huie","year":"1993","unstructured":"Huie RE, Padmaja S: The reaction of NO with superoxide. Free Radic Res Commun 18: 195-199, 1993","journal-title":"Free Radic Res Commun"},{"key":"5140033_CR171","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0306-3623(00)00062-8","volume":"34","author":"S Andreopoulos","year":"2000","unstructured":"Andreopoulos S, Papapetropoulos A: Molecular aspects of soluble guanylyl cyclase regulation. Gen Pharmacol 34: 147-158, 2000","journal-title":"Gen Pharmacol"},{"key":"5140033_CR172","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1152\/japplphysiol.00829.2001","volume":"92","author":"S Earley","year":"2002","unstructured":"Earley S, Nelin LD, Chicoine LG, Walker BR: Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric oxide. J Appl Physiol 92: 1152-1158, 2002","journal-title":"J Appl Physiol"},{"key":"5140033_CR173","first-page":"1407","volume":"60","author":"LG Moore","year":"1986","unstructured":"Moore LG, Harrison GL, McCullough RE, McCullogh RG, Micco AJ, Tucker A, Weil JV, Reeves JT: Low acute hypoxic ventilatory response and hypoxic depression in acute altitude sickness. J Appl Biol 60: 1407-1412, 1986","journal-title":"J Appl Biol"},{"key":"5140033_CR174","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1378\/chest.111.1.58","volume":"111","author":"RL Ge","year":"1997","unstructured":"Ge RL, Matsuzawa Y, Takeoka M, Kubo K, Sekiguchi M, Kobayashi T: Low pulmonary diffusing capacity in subjects with acute mountain sickness. Chest 111: 58-64, 1997","journal-title":"Chest"},{"key":"5140033_CR175","first-page":"73","volume-title":"Hypoxia and Mountain Medicine","author":"P B\u00e4rtsch","year":"1992","unstructured":"B\u00e4rtsch P, Shaw S, Wiedmann P, Franciolli M, Maggiorini M, Oelz O: Aldosterone, antidiuretic hormone and atrial natriuretic peptide in acute mountain sickness. In: J.R. Sutton, G. Coates, C.S. Houston (eds). Hypoxia and Mountain Medicine. Queen City Press, Burlington, VT, 1992, pp 73-81"},{"key":"5140033_CR176","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1152\/jappl.1988.65.5.1929","volume":"65","author":"P B\u00e4rtsch","year":"1988","unstructured":"B\u00e4rtsch P, Shaw S, Francioli M, Gnadinger MP, Weidmann P: Atrial natriuretic peptide in acute mountain sickness. J Appl Physiol 65: 1929-1937, 1988","journal-title":"J Appl Physiol"},{"key":"5140033_CR177","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1113\/jphysiol.1995.sp021099","volume":"489","author":"K Nakanishi","year":"1995","unstructured":"Nakanishi K, Tajima F, Nakamura A, Yagura S, Ookawara T, Yamashita H, Suzuki K, Taniguchi N, Ohno H: Effects of hypobaric hypoxia on antioxidant enzymes in rats. J Physiol 489: 869-876, 1995","journal-title":"J Physiol"},{"key":"5140033_CR178","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1242\/jeb.204.18.3161","volume":"204","author":"RC Roach","year":"2001","unstructured":"Roach RC, Hackett PH: Frontiers of hypoxia research: Acute mountain sickness. J Exp Biol 204: 3161-3170, 2001","journal-title":"J Exp Biol"},{"key":"5140033_CR179","first-page":"559","volume":"42","author":"C Sartori","year":"1997","unstructured":"Sartori C, Truch L, Scherrer: High-altitude pulmonary edema: Mechanisms and management. Cardiologia 42: 559-567, 1997","journal-title":"Cardiologia"},{"key":"5140033_CR180","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1056\/NEJM199603073341003","volume":"334","author":"U Scherrer","year":"1996","unstructured":"Scherrer U, Vollenweider L, DeLabays A, Savcic M, Eichenberger U, Kleger G, Firkle A, Ballmer P, Nicod P, Bartch P: Inhaled nitric oxide for high altitude pulmonary edema. N Engl J Med 334: 624-629, 1996","journal-title":"N Engl J Med"},{"key":"5140033_CR181","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1161\/01.CIR.99.20.2665","volume":"99","author":"C Sartori","year":"1999","unstructured":"Sartori C, Vollenweider L, Loffler B-M, Delabays A, Nicod P, Bartch P, Scherrer U: Exaggerated endothelin release in high-altitude pulmonary edema. Circulation 99: 2665-2668, 1999","journal-title":"Circulation"},{"key":"5140033_CR182","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1164\/ajrccm.162.1.9908039","volume":"162","author":"H Duplain","year":"2000","unstructured":"Duplain H, Sartori C, Lepori M, Egli M, Allemann Y, Nicod P, Scherrer U: Exhaled nitric oxide in high altitude pulmonary edema. Am J Resir Crit Care Med 162: 221-224, 2000","journal-title":"Am J Resir Crit Care Med"},{"key":"5140033_CR183","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-4615-4711-2_8","volume":"474","author":"U Scherrer","year":"1999","unstructured":"Scherrer U, Sartori C, Lepori H Duplain, H Treub L, Nicod P: High altitude pulmonary edema: From exaggereted pulmonary hypertension to a defect in transepithelial sodium transport. Adv Exp Med Biol 474: 93-107, 1999","journal-title":"Adv Exp Med Biol"},{"key":"5140033_CR184","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1152\/jappl.2000.88.5.1890","volume":"88","author":"C Clericii","year":"2000","unstructured":"Clericii C, Matthay MA: Hypoxia regulates gene expression of alveolar epithelial transport proteins. J Appl Physiol 88: 1890-1896, 2000","journal-title":"J Appl Physiol"},{"key":"5140033_CR185","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1152\/jappl.1999.87.3.962","volume":"87","author":"S Suzuki","year":"1999","unstructured":"Suzuki S, Noda M, Sugita M, Ono S, Koike K, Fujimara S: Impairment of transvascular fluid transport and lung Na+-K+-ATPase function by hypoxia in rats. J Appl Physiol 87: 962-968, 1999","journal-title":"J Appl Physiol"},{"key":"5140033_CR186","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1165\/ajrcmb.15.5.8918370","volume":"15","author":"C Marshall","year":"1996","unstructured":"Marshall C, Mamary AJ, Verhoeven AJ, Marshall BE: Pulmonary artery NADPH oxidase is activated in hypoxic pulmonary vasoconstriction. Am J Res Cell Mol Biol 15: 633-644, 1996","journal-title":"Am J Res Cell Mol Biol"},{"key":"5140033_CR187","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/1043-4666(91)90015-6","volume":"3","author":"P Ghezzi","year":"1991","unstructured":"Ghezzi P, Dinarello CA, Bianchi M, Rosandich ME, Repine JE, White CW: Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells. Cytokine 3: 189-194, 1991","journal-title":"Cytokine"},{"key":"5140033_CR188","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1152\/jappl.1996.81.5.1917","volume":"81","author":"GR Kleger","year":"1996","unstructured":"Kleger GR, Bartsch P, Vock P, Heilig B, Roberts LN, Ballmer PE: Evidence against an increase in capillary permeability in subjects exposed to high altitude. J Appl Physiol 81: 1917-1923, 1996","journal-title":"J Appl Physiol"},{"key":"5140033_CR189","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1136\/thx.51.7.739","volume":"51","author":"K Kubo","year":"1996","unstructured":"Kubo K, Hanaoka M, Yamaguchi S, Hayano T, Hayasaka M, Koizumi T, Fujimoto K, Kobayashi T, Honda T: Cytokines in bronchoalvcolar lavage fluid in patients with high altitude pulmonary oedema at moderate altitude in Japan. Thorax 51: 739-742, 1996","journal-title":"Thorax"},{"key":"5140033_CR190","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s004210050074","volume":"81","author":"V Pavlicek","year":"2000","unstructured":"Pavlicek V, Marti HH, Grad S, Gibbs JS, Kol C, Wenger RH, Gassmann M, Kohl J, Maly FE, Oelz O, Koller EA, Schirlo C: Effects of hypobaric hypoxia on vascular endothelial growth factor and the acute phase response in subjects who are susceptible to high-altitude pulmonary edema. Eur J Appl Physiol 81: 497-503, 2000","journal-title":"Eur J Appl Physiol"},{"key":"5140033_CR191","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1089\/152702901750265279","volume":"2","author":"KA Fagan","year":"2001","unstructured":"Fagan KA, Weil JV: Potential genetic contributions to control of the pulmonary circulation and ventilation at high altitude. High Alt Med Biol 2: 165-171, 2001","journal-title":"High Alt Med Biol"},{"key":"5140033_CR192","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1152\/jappl.1989.66.3.1152","volume":"66","author":"Y Matsuzawa","year":"1989","unstructured":"Matsuzawa Y, Fujimoto K, Kobayashi T, Namushi NR, Harada K, Kohno H, Fukushima M, Kusama S: Blunted hypoxic ventilatory drive in subjects susceptible to high-altitude pulmonary edema. J Appl Physiol 66: 1152-1157, 1989","journal-title":"J Appl Physiol"},{"key":"5140033_CR193","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1164\/arrd.1987.135.4.896","volume":"135","author":"PH Heckett","year":"1987","unstructured":"Heckett PH, Roach RC, Harrison GL, Schoene RB, Mills WJ Jr: Respiratory stimulants and sleep periodic breathing at high altitude. Almitrine vs. acetazolamide. Am Rev Respir Dis 135: 896-898, 1987","journal-title":"Am Rev Respir Dis"},{"key":"5140033_CR194","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0002-9149(69)90517-7","volume":"23","author":"D Penazola","year":"1969","unstructured":"Penazola D, Sime F: Circulatory dynamics during high altitude pulmonary edema. Am J Cardiol 23: 369-378, 1969","journal-title":"Am J Cardiol"},{"key":"5140033_CR195","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1161\/01.CIR.44.5.759","volume":"44","author":"HN Hultgren","year":"1971","unstructured":"Hultgren HN, Grover RF, Hartley LH: Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema. Circulation 44: 759-770, 1971","journal-title":"Circulation"},{"key":"5140033_CR196","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1164\/ajrccm\/142.4.796","volume":"142","author":"H Yagi","year":"1990","unstructured":"Yagi H, Yamada H, Kobayashi T, Sekiguchi M: Doppler assessment of pulmonary hypertension induced by hypoxic breathing in subjects susceptible to high altitude pulmonary edema. Am Rev Respir Dis 142: 796-801, 1990","journal-title":"Am Rev Respir Dis"},{"key":"5140033_CR197","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/jappl.1996.81.2.911","volume":"81","author":"MW Eldridge","year":"1996","unstructured":"Eldridge MW, Podolsky A, Richardson RS, Johnson DH, Knight DR, Johnson EC, Hopkins SR, Michimata HO, Grassi B, Feiner J, Kurdak SS, Bickler PE, Wagner PD, Severinghaus JW: Pulmonary hemodynamic response to exercise in subjects with prior high-altitude pulmonary edema. J Appl Physiol 81: 911-921, 1996","journal-title":"J Appl Physiol"},{"key":"5140033_CR198","first-page":"332","volume":"134","author":"R Naeije","year":"1986","unstructured":"Naeije R, Melot C, Lejeune P: Hypoxic pulmonary vasoconstriction and high altitude pulmonary edema. Am Rev Respir Dis 134: 332-333, 1986","journal-title":"Am Rev Respir Dis"},{"key":"5140033_CR199","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1152\/jappl.1984.56.4.1027","volume":"56","author":"NK Burki","year":"1984","unstructured":"Burki NK: Effects of acute exposure to high altitude on ventilatory drive and respiratory pattern. J Appl Physiol 56: 1027-1031, 1984","journal-title":"J Appl Physiol"},{"key":"5140033_CR200","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1152\/jappl.1987.62.2.640","volume":"60","author":"PR Bender","year":"1987","unstructured":"Bender PR, Weil JV, Reeves JT, Moore LG: Breathing pattern in hypoxic exposures of varying duration. J Appl Physiol 60: 640-645, 1987","journal-title":"J Appl Physiol"},{"key":"5140033_CR201","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1152\/jappl.1988.64.3.1268","volume":"64","author":"PH Hackett","year":"1988","unstructured":"Hackett PH, Roach RC, Schoene RB, Harrison GL, Mills WJ Jr: Abnormal control of ventilation in high-altitude pulmonary edema. J Appl Physiol 64: 1268-1272, 1988","journal-title":"J Appl Physiol"},{"key":"5140033_CR202","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0140-6736(99)00206-8","volume":"353","author":"NW Morrell","year":"1999","unstructured":"Morrell NW, Sarybaev AS, Alikhan A, Mirrakhimov MM, Aldashev AA: ACE genotype and risk of high altitude pulmonary hypertension in Kyrghyz highlanders. Lancet 353: 814, 1999","journal-title":"Lancet"},{"key":"5140033_CR203","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1126\/science.274.5287.536","volume":"274","author":"ES Lander","year":"1996","unstructured":"Lander ES: The new genomics: Global views of biology. Science 274: 536-539, 1996","journal-title":"Science"},{"key":"5140033_CR204","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/10290","volume":"22","author":"M Cargill","year":"1999","unstructured":"Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES: Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nature Genet 22: 231-238, 1999","journal-title":"Nature Genet"},{"key":"5140033_CR205","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/10297","volume":"22","author":"MK Haluska","year":"1999","unstructured":"Haluska MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshultz R, Chakravarti A: Patterns of single nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nature Genet 22: 239-247, 1999","journal-title":"Nature Genet"},{"key":"5140033_CR206","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/35015701","volume":"405","author":"DJ Lockhart","year":"2000","unstructured":"Lockhart DJ, Winzeler EA: Genomics, gene expression and DNA arrays. Nature Lond 405: 827-836, 2000","journal-title":"Nature Lond"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026080320034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1026080320034\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026080320034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:50:34Z","timestamp":1747749034000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1026080320034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":206,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["5140033"],"URL":"https:\/\/doi.org\/10.1023\/a:1026080320034","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11]]}}}