{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T11:33:29Z","timestamp":1778326409463,"version":"3.51.4"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Protein Chem"],"published-print":{"date-parts":[[1997,8]]},"DOI":"10.1023\/a:1026314722607","type":"journal-article","created":{"date-parts":[[2003,11,4]],"date-time":"2003-11-04T00:30:08Z","timestamp":1067905808000},"page":"565-574","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Proton Nuclear Magnetic Resonance Studies on Huwentoxin-I from the Venom of the Spider Selenocosmia huwena: 2. Three-Dimensional Structure in Solution"],"prefix":"10.1007","volume":"16","author":[{"given":"Youxing","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jizhen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuchai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renji","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocheng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1997,8,1]]},"reference":[{"key":"425458_CR1","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/BF00211756","volume":"5","author":"K. Arai","year":"1995","unstructured":"Arai, K., Ishima, R., Morikawa, S., Miyasaka, A., Imoto, T., Yoshimura, S., Aimoto, S., and Akasaka, K. (1995a). J. Biol. NMR\n5, 297\u2013305.","journal-title":"J. Biol. NMR"},{"key":"425458_CR2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0014-5793(95)00819-U","volume":"370","author":"V. J. Basus","year":"1995","unstructured":"Basus, V. J., Nadasdi, L., Ramachandran, J., and Miljanich, G.P. (1995). FEBS Lett.\n370, 163\u2013169.","journal-title":"FEBS Lett."},{"key":"425458_CR3","first-page":"355","volume":"65","author":"A. Bax","year":"1985","unstructured":"Bax, A., and Davis, D. G. (1985), J. Magn. Reson., 65, 355\u2013360.","journal-title":"J. Magn. Reson."},{"key":"425458_CR4","first-page":"542","volume":"44","author":"A. Bax","year":"1981","unstructured":"Bax, A., and Freeman, R. (1981). J. Magn. Resonance\n44, 542\u2013561.","journal-title":"J. Magn. Resonance"},{"key":"425458_CR5","first-page":"521","volume":"53","author":"L. Braunschweiler","year":"1983","unstructured":"Braunschweiler, L., and Ernst, R. R. (1983). J. Magn. Reson.\n53, 521\u2013528.","journal-title":"J. Magn. Reson."},{"key":"425458_CR6","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1002\/pro.5560020413","volume":"2","author":"S. M. Brocklehurst","year":"1993","unstructured":"Brocklehurst, S. M., and Perham, R. N. (1993). Protein Sci.\n2, 626\u2013639.","journal-title":"Protein Sci."},{"key":"425458_CR7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"B. Brooks","year":"1983","unstructured":"Brooks, B., Bruccoleri, R., Olafson, B., States, D., Swaminathan, S., and Karplus, M. (1983). J. Comp. Chem.\n4, 187\u2013217.","journal-title":"J. Comp. Chem."},{"key":"425458_CR8","volume-title":"X-PLOR Version 3.1. A System for X-ray Crystallography and NMR","author":"A. T. Brunger","year":"1992","unstructured":"Brunger, A. T. (1992). X-PLOR Version 3.1. A System for X-ray Crystallography and NMR, Yale University Press, New Haven, Connecticut."},{"key":"425458_CR9","doi-asserted-by":"publisher","first-page":"7396","DOI":"10.1021\/bi00080a009","volume":"32","author":"J. H. Davis","year":"1993","unstructured":"Davis, J. H., Bradley, E. K., Miljanich, G. P., Nadasdi, L., Ramachandran, J., and Basus, V. J. (1993). Biochemistry\n32, 7396\u20137405.","journal-title":"Biochemistry"},{"key":"425458_CR10","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1006\/jmbi.1995.0205","volume":"248","author":"S. Farr-Jones","year":"1995","unstructured":"Farr-Jones, S., Miljanich, G. P., Nadasdi, L., Ramanchandran, J., and Basus, V. J. (1995). J. Mol. Biol.\n248, 106\u2013124.","journal-title":"J. Mol. Biol."},{"key":"425458_CR11","first-page":"474","volume":"75","author":"C. Griesinger","year":"1987","unstructured":"Griesinger, C., Sorensen, O. W., and Ernst, R. R. (1987). J. Magn. Reson.\n75, 474\u2013492.","journal-title":"J. Magn. Reson."},{"key":"425458_CR12","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1021\/bi00432a009","volume":"28","author":"A. Heitz","year":"1989","unstructured":"Heitz, A., Chiche, L., Le-Nguyen, D., and Castro, B. (1989). Biochemistry\n28, 2392\u20132398.","journal-title":"Biochemistry"},{"key":"425458_CR13","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/0022-2836(89)90137-X","volume":"210","author":"T. A. Holak","year":"1989","unstructured":"Holak, T. A., Gondol, D., Otlewski, J., and Wilusz, T. (1989). J. Mol. Biol.\n210, 635\u2013648.","journal-title":"J. Mol. Biol."},{"key":"425458_CR14","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1021\/ja00008a072","volume":"113","author":"T. A. Holak","year":"1991","unstructured":"Holak, T. A., Habazettl, J., Oschkinat, H., and Otlewski, J. (1991). J. Am. Chem. Soc.\n113, 3196\u20133198.","journal-title":"J. Am. Chem. Soc."},{"key":"425458_CR15","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1002\/pro.5560010606","volume":"1","author":"S. G. Hyberts","year":"1992","unstructured":"Hyberts, S. G., Goldberg, M. S., Havel, T. F., and Wagner, G. (1992). Protein Sci.\n1, 736\u2013751.","journal-title":"Protein Sci."},{"key":"425458_CR16","first-page":"454","volume":"71","author":"T. Imoto","year":"1991","unstructured":"Imoto, T., Miyasaka, A., Ishima, R., and Akasaka, K. (1991). Comput. Biochem. Phys.\n71, 454\u20134553.","journal-title":"Comput. Biochem. Phys."},{"key":"425458_CR17","doi-asserted-by":"publisher","first-page":"4546","DOI":"10.1063\/1.438208","volume":"71","author":"J. Jeener","year":"1979","unstructured":"Jeener, J., Meier, B. H., Bachmann, P., and Ernst, R. R. (1979). J. Chem. Phys.\n71, 4546\u20134553.","journal-title":"J. Chem. Phys."},{"key":"425458_CR18","doi-asserted-by":"publisher","first-page":"4546","DOI":"10.1063\/1.438208","volume":"71","author":"J. Jeener","year":"1979","unstructured":"Jeener, J., Meier, B. H., Bachmann, P., and Ernst, R. R. (1979). J. Chem. Phys.\n71, 4546\u20134553.","journal-title":"J. Chem. Phys."},{"key":"425458_CR19","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1006\/jmbi.1995.0406","volume":"250","author":"J. I. Kim","year":"1995","unstructured":"Kim, J. II., Konishi, S., Iwai, H., Kohno, T., Gouda, H., Shimada, I., Sato, K., and Arata, Y. (1995). J. Mol. Biol.\n250, 659\u2013671.","journal-title":"J. Mol. Biol."},{"key":"425458_CR20","doi-asserted-by":"publisher","first-page":"10,256","DOI":"10.1021\/bi00032a020","volume":"34","author":"T. Kohno","year":"1995","unstructured":"Kohno, T., Kim, J. II., Kobayashi, K., Kodera, Y., Maeda, T., and Sato, K. (1995). Biochemistry\n34, 10,256\u201310,265.","journal-title":"Biochemistry"},{"key":"425458_CR21","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1107\/S0021889892009944","volume":"26","author":"R. Laskowski","year":"1993","unstructured":"Laskowski, R., MacArthur, M. W., Moss, F. S., and Thornton, J. M. (1993). J. Appl. Cryst.\n26, 283\u2013291.","journal-title":"J. Appl. Cryst."},{"key":"425458_CR22","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0005-2795(73)90350-4","volume":"303","author":"P. N. Lewis","year":"1973","unstructured":"Lewis, P. N., Momany, F. A., and Seheraga, H. A. (1973). Biochim. Biophys. Acta\n303, 211\u2013229.","journal-title":"Biochim. Biophys. Acta"},{"key":"425458_CR23","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1016\/0041-0101(93)90256-I","volume":"31","author":"S. P. Liang","year":"1993","unstructured":"Liang, S. P., Zhang, D. Y., Pan, X., Chen, Q., and Zhou, P. A. (1993). Toxicon\n31, 969\u2013978.","journal-title":"Toxicon"},{"key":"425458_CR24","unstructured":"Liang, S. P., Xia, Z. X., and Xie, J. Y. (1997). Scientia Sinica, Series C\n27, in press."},{"key":"425458_CR25","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/0006-291X(83)91093-8","volume":"13","author":"D. Marion","year":"1983","unstructured":"Marion, D., and W\u00fcthrich, K. (1983). Biochem. Biophys. Res. Comm.\n13, 967\u2013974.","journal-title":"Biochem. Biophys. Res. Comm."},{"key":"425458_CR26","doi-asserted-by":"publisher","first-page":"3479","DOI":"10.1021\/bi00011a001","volume":"34","author":"T. D. Mulhern","year":"1995","unstructured":"Mulhern, T. D., Howlett, G. J., Reid, G. E., Sonpsin, R. J., McColl, D. J., Anders, T. F., and Norton, R. S. (1995). Biochemistry\n34, 3479\u20133491.","journal-title":"Biochemistry"},{"key":"425458_CR27","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1006\/bbrc.1995.1243","volume":"207","author":"N. Nemoto","year":"1995","unstructured":"Nemoto, N., Kubo, S., Yoshida, T., Chino, N., Kimura, T., Sakakibara, S., Kyogoku, Y., and Kobayashi, Y. (1995). Biochem. Biophys. Res. Commun.\n207, 695\u2013700.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"425458_CR28","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/pro.5560030213","volume":"3","author":"K. J. Nielsen","year":"1994","unstructured":"Nielsen, K. J., Alewood, D., Andrews, J., Kent, S. B. H., and Craik, D. J. (1994). Protein Sci.\n3, 291\u2013302.","journal-title":"Protein Sci."},{"key":"425458_CR29","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/0022-2836(91)90189-D","volume":"219","author":"M. Nilges","year":"1991","unstructured":"Nilges, M., Habazettl, J., Brunger, A. T., and Holak, T. A. (1991). J. Mol. Biol.\n219, 499\u2013510.","journal-title":"J. Mol. Biol."},{"key":"425458_CR30","doi-asserted-by":"publisher","first-page":"22,067","DOI":"10.1016\/S0021-9258(18)54531-2","volume":"266","author":"B. M. Olivera","year":"1991","unstructured":"Olivera, B. M., Riveier, J., Scott, J. K., Hillyard, D. R., and Cruz. L. J. (1991). J. Biol. Chem.\n266, 22,067\u201322,070.","journal-title":"J. Biol. Chem."},{"key":"425458_CR31","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1006\/jmbi.1993.1595","volume":"234","author":"P. K. Pallaghy","year":"1993","unstructured":"Pallaghy, P. K., Duggan, B. M., Pennington, M. W., and Norton, R. S. (1993). J. Mol. Biol.\n234, 405\u2013420.","journal-title":"J. Mol. Biol."},{"key":"425458_CR32","doi-asserted-by":"publisher","first-page":"1833","DOI":"10.1002\/pro.5560031022","volume":"3","author":"P. K. Pallaghy","year":"1994","unstructured":"Pallaghy, P. K., Nielsen, K. J., Craik, D. J., and Norton, R. S. (1994). Protein Sci.\n3, 1833\u20131839.","journal-title":"Protein Sci."},{"key":"425458_CR33","doi-asserted-by":"publisher","first-page":"5494","DOI":"10.1021\/bi00439a026","volume":"28","author":"A. Pardi","year":"1989","unstructured":"Pardi, A., Galdes, A., Florance, J., and Maniconte, D. (1989). Biochemistry\n28, 5494\u20135501.","journal-title":"Biochemistry"},{"key":"425458_CR34","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/BF01886881","volume":"14","author":"Y. Qu","year":"1995","unstructured":"Qu, Y., Liang, S., Ding, J., Ma, L., Zhang, R., and Gu, X. (1995). J. Protein Chem.\n14, 549\u2013557.","journal-title":"J. Protein Chem."},{"key":"425458_CR35","doi-asserted-by":"crossref","unstructured":"Rance, M., Sorensen, O. W., Bodenhausen, G., Wagner, G., Ernst, R. R., and Wuthrich, K. (1983). 117, 479\u2013485.","DOI":"10.1016\/0006-291X(83)91225-1"},{"key":"425458_CR36","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1007\/BF00208803","volume":"5","author":"M. D. Reily","year":"1995","unstructured":"Reily, M. D., Thanabal, V., and Adams, M. E. (1995). J. Biomol. NMR\n5, 122\u2013132.","journal-title":"J. Biomol. NMR"},{"key":"425458_CR37","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0065-3233(08)60520-3","volume":"34","author":"J. S. Richardson","year":"1981","unstructured":"Richardson, J. S. (1981). Adv. Protein Chem.\n34, 167\u2013339.","journal-title":"Adv. Protein Chem."},{"key":"425458_CR38","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1006\/bbrc.1993.1549","volume":"192","author":"P. Sevilla","year":"1993","unstructured":"Sevilla, P., Bruix, M., Santoro, J., Gago, F., Garcia, A. G., and Rico, M. (1993). Biochem. Biophys. Res. Commun.\n192, 1238\u20131244.","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"425458_CR39","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/pro.5560021005","volume":"2","author":"J. J. Skalicky","year":"1993","unstructured":"Skalicky, J. J., Metzler, W. J., Ciesla, D. J., Galdes, A., and Pardi, A. (1993). Protein Sci.\n2, 1591\u20131603.","journal-title":"Protein Sci."},{"key":"425458_CR40","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1093\/protein\/3.6.479","volume":"3","author":"C. M. Wilmot","year":"1990","unstructured":"Wilmot, C. M., and Thornton, J. M. (1990). Protein Eng.\n3, 479\u2013493.","journal-title":"Protein Eng."},{"key":"425458_CR41","doi-asserted-by":"publisher","DOI":"10.1051\/epn\/19861701011","volume-title":"NMR of Proteins and Nucleic Acids","author":"K. Wuthrich","year":"1986","unstructured":"Wuthrich, K. (1986). NMR of Proteins and Nucleic Acids, Wiley, New York."},{"key":"425458_CR42","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S0022-2836(83)80144-2","volume":"169","author":"K. Wuthrich","year":"1983","unstructured":"Wuthrich, K., Billeter, M., and Braun, W. (1983). J. Mol. Biol.\n169, 949\u2013961.","journal-title":"J. Mol. Biol."},{"key":"425458_CR43","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/BF01024931","volume":"12","author":"D. Zhang","year":"1993","unstructured":"Zhang, D., and Liang, S. P. (1993). J. Protein Chem.\n12, 735\u2013740.","journal-title":"J. Protein Chem."},{"key":"425458_CR44","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0041-0101(96)00072-4","volume":"35","author":"P. A. Zhou","year":"1997","unstructured":"Zhou, P. A., Xie, X. J., Li, M., Yang, D. M., Xie, Z. P., Zong, X., and Liang, S. P. (1997). Toxicon\n35, 39\u201345.","journal-title":"Toxicon"}],"container-title":["Journal of Protein Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026314722607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1026314722607\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026314722607.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T09:46:52Z","timestamp":1751622412000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1026314722607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["425458"],"URL":"https:\/\/doi.org\/10.1023\/a:1026314722607","relation":{},"ISSN":["0277-8033","1573-4943"],"issn-type":[{"value":"0277-8033","type":"print"},{"value":"1573-4943","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8]]},"assertion":[{"value":"1 August 1997","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}