{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:19:25Z","timestamp":1780701565777,"version":"3.54.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,8,1]]},"abstract":"<jats:p>The possible protective effect of kolaviron on rat erythrocytes followingsimultaneous administration of kolaviron (100 mg\/kg of body weight\/day) withcarbon tetrachloride CCl4 (1.195 g\/kg of body weight\/day) by separateintraperitoneal injections was investigated.<\/jats:p>\n               <jats:p>Kolaviron, a biflavonoid fraction of the defatted alcoholic extract of Garcinia kola seed, inhibits the accumulation of lipid peroxidationproducts in erythrocytes. A significant reduction (p&amp;gt;0.05) by about34% of lipid peroxidation products was observed in erythrocytes of ratstreated simultaneously with CCl4 and kolaviron when compared to CCl4-treatedrats. Similarly, the significant increase (p &amp;gt;0.05) in membranecholesterol observed in CCl4-treated rats was significantly decreased(p&amp;gt;0.05) in rats treated simultaneously with CCl4 andkolaviron. Therefore, there was no significant difference (p &amp;gt;0.05) incholesterol\u2013phospholipid ratio (C\/P) of rats treated simultaneouslywith CCl4 and kolaviron, and the controls. Thus, kolaviron normalizes the CCl4-induced change in erythrocyte membrane composition.<\/jats:p>\n               <jats:p>In addition, kolaviron antagonizes the effect of CCl4 on the activity ofthe membrane bound enzyme, Ca2+-ATPase. These results suggest thatkolaviron protects erythrocyte membranes from free radical attack, on bothlipids and proteins.<\/jats:p>","DOI":"10.1023\/a:1026488823157","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T16:45:40Z","timestamp":1068137140000},"page":"259-264","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Possible Protective Effect of Kolaviron on CCl4-Induced Erythrocyte Damage in Rats"],"prefix":"10.1042","volume":"20","author":[{"given":"Oluwatosin A.","family":"Adaramoye","sequence":"first","affiliation":[{"name":"Laboratory for Biochemical\/Molecular Toxicology, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluyemi","family":"Akinloye","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/20\/4\/259\/470088\/bsr0200259.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/20\/4\/259\/470088\/bsr0200259.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T17:51:25Z","timestamp":1637085085000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/20\/4\/259\/54416\/Possible-Protective-Effect-of-Kolaviron-on-CCl4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,8,1]]}},"URL":"https:\/\/doi.org\/10.1023\/a:1026488823157","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,1]]}}}