{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:47:16Z","timestamp":1780444036663,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1023\/a:1026623028794","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T12:29:30Z","timestamp":1068121770000},"page":"1312-1316","source":"Crossref","is-referenced-by-count":13,"title":["Esophageal Small Cell Carcinoma with Ectopic Production of Parathyroid Hormone-Related Protein (PTHrp), Secretin, and Granulocyte Colony-Stimulating Factor (G-CSF)"],"prefix":"10.1007","volume":"44","author":[{"given":"Ryuichi","family":"Nagashima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Mabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"296183_CR1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/1097-0142(19891001)64:7<1531::AID-CNCR2820640729>3.0.CO;2-0","volume":"64","author":"LN Nichols","year":"1989","unstructured":"Nichols LN, Kelsen DP: Small cell carcinoma of the esophagus. The Memorial Hospital experience 1970 to 1987. Cancer 64:1531\u20131533, 1989","journal-title":"Cancer"},{"key":"296183_CR2","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1002\/1097-0142(19940615)73:12<2894::AID-CNCR2820731204>3.0.CO;2-M","volume":"73","author":"SYK Law","year":"1994","unstructured":"Law SYK, Fok M, Lam KY, Loke SL, Ma LT, Wong J: Small cell carcinoma of the esophagus. Cancer 73:2894\u20132899, 1994","journal-title":"Cancer"},{"key":"296183_CR3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1378\/chest.107.1.179","volume":"107","author":"M Huncharek","year":"1995","unstructured":"Huncharek M, Muscat J: Small cell carcinoma of the esophagus. The Massachusetts General Hospital experience, 1978 to 1993. Chest 107:179\u2013181, 1995","journal-title":"Chest"},{"key":"296183_CR4","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0022-5223(95)70390-X","volume":"109","author":"SR Craig","year":"1995","unstructured":"Craig SR, Carey FA, Walker WS, Cameron EWJ: Primary small-cell cancer of the esophagus. J Thorac Cardiovasc Surg 109:284\u2013288, 1995","journal-title":"J Thorac Cardiovasc Surg"},{"key":"296183_CR5","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/S0022-5223(94)70158-X","volume":"108","author":"MD Lieberman","year":"1994","unstructured":"Lieberman MD, Franceschi D, Marsan B, Burt M: Esophageal carcinoma. The unusual variants. J Thorac Cardiovasc Surg 108:1138\u20131146, 1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"296183_CR6","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/1097-0142(19841015)54:8<1645::AID-CNCR2820540828>3.0.CO;2-Q","volume":"54","author":"NB Ibrahim","year":"1984","unstructured":"Ibrahim NB, Briggs JC, Corbishley CM: Extrapulmonary oat cell carcinoma. Cancer 54:1645\u20131661, 1984","journal-title":"Cancer"},{"key":"296183_CR7","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0046-8177(84)80081-7","volume":"15","author":"KJ Ho","year":"1984","unstructured":"Ho KJ, Herrera GA, Jones JM: Small cell carcinoma of the esophagus: Evidence of a unified histogenesis. Hum Pathol 15:460\u2013468, 1984","journal-title":"Hum Pathol"},{"key":"296183_CR8","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00004836-198812000-00020","volume":"10","author":"K Sasajima","year":"1988","unstructured":"Sasajima K, Hayasi N, Yamashita K, Onda M, Takubo K: Oat cell carcinoma of the esophagus with multiple differentiation. J Clin Gastroenterol 10:667\u2013671, 1988","journal-title":"J Clin Gastroenterol"},{"key":"296183_CR9","first-page":"235","volume":"2","author":"D Carter","year":"1985","unstructured":"Carter D, Yesner R: Carcinomas of the lung with neuroendocrine differentiation. Semin Diagn Pathol 2:235\u2013254, 1985","journal-title":"Semin Diagn Pathol"},{"key":"296183_CR10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/BF01600272","volume":"420","author":"M Bonato","year":"1992","unstructured":"Bonato M, Cerati M, Pagani A, Papotti M, Bosi F, Bussolati G, Capella C: Differential diagnostic patterns of lung neuroendocrine tumors. A clinicopathological and immunohistochemical study of 122 cases. Virchows Arch A 420:201\u2013211, 1992","journal-title":"Virchows Arch A"},{"key":"296183_CR11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/BF01316813","volume":"38","author":"T Nishimaki","year":"1993","unstructured":"Nishimaki T, Susuzki T, Fukuda T, Aizawa K, Tanaka O, Muto T: Primary small cell carcinoma of the esophagus with ectopic gastrin production. Report of a case and review of the literature. Dig Dis Sci 38:767\u2013771, 1993","journal-title":"Dig Dis Sci"},{"key":"296183_CR12","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1002\/1097-0142(19840415)53:8<1746::AID-CNCR2820530822>3.0.CO;2-V","volume":"53","author":"FE Johnson","year":"1984","unstructured":"Johnson FE, Clawson MC, Bashiti M, Silverberg AB, Broun GO: Small cell undifferentiated carcinoma of the esophagus. Case report with hormonal studies. Cancer 53:1746\u20131751, 1984","journal-title":"Cancer"},{"key":"296183_CR13","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1002\/1097-0142(197805)41:5<1890::AID-CNCR2820410533>3.0.CO;2-Q","volume":"41","author":"T Horai","year":"1978","unstructured":"Horai T, Kobayashi A, Tateishi R, Wada A, Taniguchi H, Taniguchi K, Sano M, Tamura H: A cytologic study on small cell carcinoma of the esophagus. Cancer 41:1890\u20131896, 1978","journal-title":"Cancer"},{"key":"296183_CR14","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/0016-5085(85)90154-4","volume":"88","author":"KJR Watoson","year":"1985","unstructured":"Watoson KJR, Shulkes A, Smallwood RA, Douglas MC, Hurley R, Kalnins R, Moran L: Watery diarrhea-hypokalemia-achlorhydria syndrome and carcinoma of the esophagus. Gastroenterology 88:798\u2013803, 1985","journal-title":"Gastroenterology"},{"key":"296183_CR15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/ajcp\/77.2.123","volume":"77","author":"World Health Organization","year":"1982","unstructured":"World Health Organization: The World He alth Organization histological typing of lung tumors, 2. Am J Clin Pathol 77:123\u2013136, 1982","journal-title":"Am J Clin Pathol"},{"key":"296183_CR16","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF01746607","volume":"20","author":"G Cattoretti","year":"1988","unstructured":"Cattoretti G, Berti E, Schiro R, e t al: Improve d avidin-biotin-peroxidase complex (ABC) staining. Histochem J 20:75\u201380, 1988","journal-title":"Histochem J"},{"key":"296183_CR17","first-page":"197","volume-title":"Gastrointestinal Pathology and Its Clinical Implications","author":"KJ Lewin","year":"1992","unstructured":"Lewin KJ, Riddell RH, Weinstein WM: Endocrine cells. In Gastrointestinal Pathology and Its Clinical Implications. KJ Lewin, RH Riddell, WM Weinstein (eds). New York, Tokyo, Igaku-Shoin, 1992, pp 197\u2013257"},{"key":"296183_CR18","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1073\/pnas.84.14.5048","volume":"84","author":"JM Moseley","year":"1987","unstructured":"Moseley JM, Kubota M, Difenbach-Jagger H, Wettenhall REH, Kemp BE, Suva LJ, Rodda CP, Ebeling PR, Hudson PJ, Zajac JD, Martin TJ: Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci USA 84:5048\u20135052, 1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"296183_CR19","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/endo-128-4-1927","volume":"128","author":"S Kramer","year":"1991","unstructured":"Kramer S, Reynolds FH Jr, Castillo M, Valenzuela DM, Thorikay M, Sorvillo JM: Immunological identification and distribution of parathyroid hormone-like protein polypeptides in normal and malignant tissues. Endocrinology 128:1927\u20131937, 1991","journal-title":"Endocrinology"},{"key":"296183_CR20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1136\/jcp.44.6.472","volume":"44","author":"SH Ralston","year":"1991","unstructured":"Ralston SH, Danks J, Hayman J, Fraser WD, Stewart CS, Martin T: Parathyroid hormone-re lated protein of malignancy: Immunohistochemical and biochemical studies in normocalcaemic and hype rcalcaemic patients with cancer. J Clin Pathol 44:472\u2013476, 1991","journal-title":"J Clin Pathol"},{"key":"296183_CR21","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.3616618","volume":"237","author":"LJ Suva","year":"1987","unstructured":"Suva LJ, Winslow GA, Wettenhall REH, Hammonds RG, Moseley JM, Diefenbach-Jagger, Rodda CP, Kemp BE, Rodriguez H, Chen EY, Hudson PJ, Martin TJ, Wood WI: A parathyroid hormone-related protein implicated in malignant hypercalcemia: Cloning and expression. Science 237:893\u2013896, 1987","journal-title":"Science"},{"key":"296183_CR22","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1002\/1097-0142(19911215)68:12<2625::AID-CNCR2820681219>3.0.CO;2-T","volume":"68","author":"Y Tachimori","year":"1991","unstructured":"Tachimori Y, Watanabe H, Kato H, Yamaguchi H, Nagasaki K, Honda S, Itabashi M, Yamaguchi K: Hypercalcemia in patients with esophageal carcinoma. The pathophysiologic role of parathyroid hormone-related protein. Cancer 68:2625\u20132629, 1991","journal-title":"Cancer"},{"key":"296183_CR23","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1182\/blood.V61.3.600.600","volume":"61","author":"W Hocking","year":"1983","unstructured":"Hocking W, Goodman J, Golde D: Granulocytosis associated with tumor cell production of colony-stimulating activity. Blood 61:600\u2013603, 1983","journal-title":"Blood"},{"key":"296183_CR24","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/1097-0142(19870815)60:4<903::AID-CNCR2820600431>3.0.CO;2-6","volume":"60","author":"JL Ascensao","year":"1987","unstructured":"Ascensao JL, Oken MM, Ewing SL, Goldberg RJ, Kaplan ME: Leukocytosis and lung cell cancer. A frequent association. Cancer 60:903\u2013905, 1987","journal-title":"Cancer"},{"key":"296183_CR25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1182\/blood.V73.1.117.117","volume":"73","author":"K Watari","year":"1989","unstructured":"Watari K, Asano S, Shirafuji N, Kodo H, Ozawa K, Takaku F, Kamachi S: Serum granulocyte colony-stimulating factor leve ls in healthy volunteers and patients with various disordersas estimated by enzyme immunoassay. Blood 73:117\u2013122, 1989","journal-title":"Blood"},{"key":"296183_CR26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF01606458","volume":"422","author":"T Ito","year":"1993","unstructured":"Ito T, Shimamura K, Shoji K, Akatsuka A, Kiryu Y, Tamaoki N, Osamura Y: Urinary bladder carcinoma producing granulocyte colony stimulating factor (G-CSF): A report with immunohistochemistry. Virchows Arch A 422:487\u2013490, 1993","journal-title":"Virchows Arch A"},{"key":"296183_CR27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1172\/JCI112544","volume":"78","author":"K Sato","year":"1986","unstructured":"Sato K, Mimura H, Han DC, Kakiuchi T, Ueyama Y, Ohkawa H, Okabe T, Kondo Y, Ohsawa N, Tsushima T, Shizume K: Production of bone-resorbing activity and colony-stimulating activity in vivo and in vitro by a squamous cell carcinoma associated with hype rcalcemia and leukocytosis. J Clin Invest 78:145\u2013154, 1986","journal-title":"J Clin Invest"},{"key":"296183_CR28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1182\/blood.V74.1.115.115","volume":"74","author":"MY Lee","year":"1989","unstructured":"Lee MY, Kaushansky K, Judkins SA, Lottsfeldt JL, Waheed A, Shadduck RK: Mechanisms of tumor-induced neutrophilia: constitutive production of colony-stimulating factors and their synergistic actions. Blood 74:115\u2013122, 1989","journal-title":"Blood"},{"key":"296183_CR29","first-page":"2821","volume-title":"Bockus Gastroenterology","author":"TE Solomon","year":"1995","unstructured":"Solomon TE: Physiology of the exocrine pancreas. In Bockus Gastroenterology, 5th ed. WS Haubrich, F Schaffner, JE Berk (eds). Philadelphia, WB Saunders, 1995, pp 2821\u20132834","edition":"5th ed."},{"key":"296183_CR30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/oxfordjournals.jbchem.a124724","volume":"117","author":"N Yamaguchi","year":"1995","unstructured":"Yamaguchi N, Koyama K, Yamamura Y, Okui A, Konishi E, Katayama T, Katsuragi N, Kurihara T, Nakazato H, Imanishi J: A novel proteinase, glucagon-degrading enzyme, secre ted by a human pancreatic cancer cell line, HPC-YO. J Biochem 117:7\u201310, 1995","journal-title":"J Biochem"},{"key":"296183_CR31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1097-0142(19940101)73:1<1::AID-CNCR2820730102>3.0.CO;2-E","volume":"73","author":"M McCullen","year":"1994","unstructured":"McCullen M, Vygas SK, Winwood PJ, Loehry CA, Parham DM, Hamblin T: Long-term survival associated with me tastatic small cell carcinoma of the esophagus treated by chemotherapy, autologus bone marrow transplantation, and adjuvant radiation therapy. Cancer 73:1\u20134, 1994","journal-title":"Cancer"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026623028794.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1026623028794\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026623028794.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:05:46Z","timestamp":1752462346000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1026623028794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["296183"],"URL":"https:\/\/doi.org\/10.1023\/a:1026623028794","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}