{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T23:45:45Z","timestamp":1774914345383,"version":"3.50.1"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1998,10,1]],"date-time":"1998-10-01T00:00:00Z","timestamp":907200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1998,10]]},"DOI":"10.1023\/a:1026646017851","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T12:29:30Z","timestamp":1068121770000},"page":"2177-2183","source":"Crossref","is-referenced-by-count":54,"title":["Pruritus as a Presenting Symptom of Chronic Hepatitis C"],"prefix":"10.1007","volume":"43","author":[{"given":"Siew-Cheng","family":"Chia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora V.","family":"Bergasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Kleiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay H.","family":"Hoofnagle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian M.","family":"Di Bisceglie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"295077_CR1","volume-title":"Transplantation of the Liver","author":"S. I. Munoz","year":"1988","unstructured":"Munoz S: InTransplantation of the Liver. WC Maddrey (ed).New York, Elsevier, 1988"},{"key":"295077_CR2","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1056\/NEJM198612183152503","volume":"315","author":"JH Hoofnagle","year":"1986","unstructured":"Hoofnagle JH, Mullen KD, Jone s DB, Rustgi V, Di Bisce glie A, Peters M, Waggoner JG, Park Y, Jones EA: Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. N Engl J Med 315:1575 - 1578, 1986","journal-title":"N Engl J Med"},{"key":"295077_CR3","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1056\/NEJM198911303212204","volume":"321","author":"AM Di Bisceglie","year":"1989","unstructured":"Di Bisceglie AM, Martin P, Kassianides C, Lisker-Melman M, Murray L, Waggoner JG, Goodman Z, Banks S, Hoofnagle JH: Recombinant interferon alfa therapy for chronic hepatitis C. N Engl J Med 321:1506 - 1510, 1989","journal-title":"N Engl J Med"},{"key":"295077_CR4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/hep.1840160307","volume":"16","author":"AM Di Bisceglie","year":"1992","unstructured":"Di Bisceglie AM, Shindo M, Fong T-L, Fried MW, Bergasa NV, Axiotis CA, Waggoner JG, Park Y, Hoofnagle JH: A pilot study of ribavirin therapy for chronic hepatitis C. Hepatology 16:649 - 654, 1992","journal-title":"Hepatology"},{"key":"295077_CR5","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/0016-5085(92)90102-5","volume":"102","author":"NV Bergasa","year":"1992","unstructured":"Bergasa NV, Talbot TL, Alling DW, Schmitt JM, Walker EC, Bake r BL, Korenman JC, Park Y, Hoofnagle JH, Jones EA: A controlled trial of naloxone infusions for the pruritus of chronic cholestasis. Gastroenterology 102:544 - 509, 1992","journal-title":"Gastroenterology"},{"key":"295077_CR6","doi-asserted-by":"crossref","first-page":"177A","DOI":"10.1016\/0270-9139(93)92233-P","volume":"18","author":"NV Bergasa","year":"1993","unstructured":"Bergasa NV, Alling DW, Talbot TL, Chia SC, Souppaya M, Conjeevaram HC, Sallie R, Yurdaydin C, Wells M, Swain MG, Di Bisceglie AM, Hoofnagle JH, Jones EA: Nalmefene therapy is associated with the relief of the pruritus of cholestasis: Results of a double-blind randomized placebo-controlled trial. Hepatology 18:177A, 1993 (abstract)","journal-title":"Hepatology"},{"key":"295077_CR7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.7326\/0003-4819-123-3-199508010-00001","volume":"123","author":"NV Bergasa","year":"1995","unstructured":"Bergasa NV, Alling DW, Talbot TL, Swain MG, Yurdaydin C, Schmitt JM, Walker EC, Turner ML, Jones EA: Naloxone ameliorate s the pruritus of cholestasis: Results of a doubleblind randomized placebo-controlled trial. Ann Intern Med 123:161 - 167, 1995","journal-title":"Ann Intern Med"},{"key":"295077_CR8","first-page":"400","volume":"25","author":"TL Talbot","year":"1991","unstructured":"Talbot TL, Schmitt JM, Bergasa NV, Jones EA, Walker EC: Application of piezo film technology for the quantitative assessment of pruritus. Biomed Instrum Technol 25:400 - 403, 1991","journal-title":"Biomed Instrum Technol"},{"key":"295077_CR9","doi-asserted-by":"crossref","first-page":"700","DOI":"10.7326\/0003-4819-115-9-700","volume":"115","author":"M Shindo","year":"1991","unstructured":"Shindo M, DiBisceglie AM, Cheung L, Shih JW-K, Cristiano K, Fe instone SM, Hoofnagle JH: Decrease in serum hepatitis C viral RNA during alpha-interferon therapy for chronic hepatitis C. Ann Intern Med 115:700 - 704, 1991","journal-title":"Ann Intern Med"},{"key":"295077_CR10","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1007\/BF02065530","volume":"40","author":"ZD Goodman","year":"1995","unstructured":"Goodman ZD, McNally PR, Davis DR, Ishak KG: Autoimmune cholangitis: A variant of primary biliary cirrhosis. Dig Dis Sci 40:1232 - 1242, 1995","journal-title":"Dig Dis Sci"},{"key":"295077_CR11","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/0016-5085(85)90001-0","volume":"88","author":"B Portmann","year":"1985","unstructured":"Portmann B, Popper H, Neuberger J, Williams R: Sequential and diagnostic features in primary biliary cirrhosis based on serial histologic study in 209 patients. Gastroenterology 88:1777 - 1790, 1985","journal-title":"Gastroenterology"},{"key":"295077_CR12","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0190-9622(94)70072-9","volume":"30","author":"DA Fisher","year":"1994","unstructured":"Fisher DA, Wright TL: Pruritus as a symptom of hepatitis C. J Am Acad Dermatol 30:629 - 632, 1994","journal-title":"J Am Acad Dermatol"},{"key":"295077_CR13","first-page":"78","volume-title":"Dermatological Signs of Internal Disease","author":"JD Bernhard","year":"1995","unstructured":"Bernhard JD, Jorizzo JL, Callen JP: Pruritus. InDermatological Signs of Internal Disease, 2nd ed. JP Callen, JL Jorizzo, KE Greer, NS Penneys, WW Piette, JJ Zone (eds). Philadelphia, WB Saunders, 1995, pp 78 - 82","edition":"2nd ed."},{"key":"295077_CR14","first-page":"254A","volume":"20","author":"S Lahoti","year":"1994","unstructured":"Lahoti S, Murakami C, Casey D, Lee W: Is there a cholestatic variant of hepatitis C? Hepatology 20:254A, 1994 (abstract)","journal-title":"Hepatology"},{"key":"295077_CR15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1055\/s-2007-1007360","volume":"13","author":"NV Bergasa","year":"1993","unstructured":"Bergasa NV, Jone s EA: The pruritus of cholestasis. Semin Liver Dis 13:319 - 327, 1993","journal-title":"Semin Liver Dis"},{"key":"295077_CR16","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/s-2007-1007354","volume":"13","author":"GM Woolf","year":"1993","unstructured":"Woolf GM, Vierling JM: Disappearing bile ducts: The syndromes and their mechanisms. Semin Liver Dis 13:261 - 275, 1993","journal-title":"Semin Liver Dis"},{"key":"295077_CR17","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1699-0463.1969.tb03269.x","volume":"76","author":"H Poulsen","year":"1969","unstructured":"Poulsen H, Christoffersen P: Abnormal bile duct epithelium in liver biopsies with histological signs of viral hepatitis. Acta Path Microbiol Scand 76:383 - 390, 1969","journal-title":"Acta Path Microbiol Scand"},{"key":"295077_CR18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1600-0676.1993.tb00648.x","volume":"13","author":"M Vyberg","year":"1993","unstructured":"Vyberg M: The hepatitis-associated bile duct lesion. Liver 13:289 - 301, 1993","journal-title":"Liver"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026646017851.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1026646017851\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026646017851.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T02:58:12Z","timestamp":1752461892000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1026646017851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,10]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1998,10]]}},"alternative-id":["295077"],"URL":"https:\/\/doi.org\/10.1023\/a:1026646017851","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,10]]}}}