{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:03:48Z","timestamp":1752537828759,"version":"3.41.2"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1023\/a:1026687022202","type":"journal-article","created":{"date-parts":[[2003,11,6]],"date-time":"2003-11-06T12:29:30Z","timestamp":1068121770000},"page":"2478-2483","source":"Crossref","is-referenced-by-count":7,"title":["Methylprednisolone Administration in Primary Biliary Cirrhosis Increases Cholic Acid Turnover, Synthesis, and Deoxycholate Concentration in Bile"],"prefix":"10.1007","volume":"44","author":[{"given":"Giuseppe","family":"Mazzella","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Fusaroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Pezzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Azzaroli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanza","family":"Mazzeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Zambonin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Simoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Festi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Roda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"296457_CR1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1056\/NEJM198702263160907","volume":"316","author":"MM Kaplan","year":"1987","unstructured":"Kaplan MM: Primary biliary cirrhosis. N Engl J Med 316:521\u2013528, 1987","journal-title":"N Engl J Med"},{"key":"296457_CR2","doi-asserted-by":"crossref","first-page":"500","DOI":"10.7326\/0003-4819-99-4-500","volume":"99","author":"SP James","year":"1983","unstructured":"James SP, Hoofnagle JH, Strober W, Jones EA: Primary biliary cirrhosis: A mode l autoimmune disease. Ann Intern Med 99:500\u2013512, 1983","journal-title":"Ann Intern Med"},{"key":"296457_CR3","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0016-5085(80)90136-5","volume":"79","author":"SP James","year":"1980","unstructured":"James SP, Elson CO, Jones EA, Strobert W: Abnormal regulation of immunoglobulin synthesis in vitro in primary biliary cirrhosis. Gastroenterology 79:242\u2013254, 1980","journal-title":"Gastroenterology"},{"issue":"suppl204","key":"296457_CR4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/00365529409103623","volume":"29","author":"A Bjorkland","year":"1994","unstructured":"Bjorkland A, Totterman TH: Is primary biliary cirrhosis an autoimmune disease? Scand J Gastroenterol 29(suppl 204):32\u201339, 1994","journal-title":"Scand J Gastroenterol"},{"key":"296457_CR5","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0140-6736(87)92421-4","volume":"2","author":"AF Hofmann","year":"1987","unstructured":"Hofmann AF, Popper H: Ursodeoxycholic acid for primary biliary cirrhosis. Lancet 2:398\u2013399, 1987","journal-title":"Lancet"},{"key":"296457_CR6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1056\/NEJM198202113060602","volume":"306","author":"DS Matloff","year":"1982","unstructured":"Matloff DS, Alpert E, Resnick RH, Kaplan MM: A prospective trial of D-penicillamine in primary biliary cirrhosis. N Engl J Med 306:319\u2013326, 1982","journal-title":"N Engl J Med"},{"key":"296457_CR7","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/0016-5085(85)90213-6","volume":"89","author":"E Christensen","year":"1985","unstructured":"Christensen E, Neuberger J, Crowe J, Altman DG, Popper H, Portmann B, Doniach D, Ranek L, Tygstrup N, Williams R: Beneficial effect of azathioprine and prediction of prognosis in primary biliary cirrhosis. Gastroenterology 89:1084\u20131091, 1985","journal-title":"Gastroenterology"},{"key":"296457_CR8","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1056\/NEJM198612043152304","volume":"315","author":"MM Kaplan","year":"1986","unstructured":"Kaplan MM, Alling DW, Zimmerman HJ, Wolfe HJ, Sepersky RA, Hirsch GS, Elta GH, Glick KA, Eagen KA: A prospective trial of colchicine for primary biliary cirrhosis. N Engl J Med 315:1448\u20131454, 1986","journal-title":"N Engl J Med"},{"key":"296457_CR9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0016-5085(93)90422-9","volume":"104","author":"M Lombard","year":"1993","unstructured":"Lombard M, Portmann B, Neuberger J, Williams R, Tygstrup N, Ranek L, Ring-Larsen H, Rodes J, Navasa M, Trepo C, Pape G, Schou G, Badsberg JH, Andersen PK: Cyclosporin A treatment in primary biliary cirrhosis: Re sults of a long term placebo controlled trial. Gastroenterology 104:519\u2013526, 1993","journal-title":"Gastroenterology"},{"key":"296457_CR10","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/hep.1840080339","volume":"8","author":"RH Wiesner","year":"1988","unstructured":"Wiesner RH, Grambsch PM, Lindor KD, Ludwig J, Dickson ER: Clinical and statistical analyse s of new and evolving therapies for primary biliary cirrhosis. Hepatology 8:668\u2013676, 1988","journal-title":"Hepatology"},{"key":"296457_CR11","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/S0016-5085(97)70183-5","volume":"113","author":"RE Poupon","year":"1997","unstructured":"Poupon RE, Lindor KD, Cauc-Dudek K, Dickson ER, Poupon R, Heathcote EJ: Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 113:884\u2013890, 1997","journal-title":"Gastroenterology"},{"key":"296457_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0168-8278(92)90123-7","volume":"14","author":"R Beukers","year":"1992","unstructured":"Beukers R, Schalm SW: Immunosuppressive therapy for primary biliary cirrhosis. J Hepatol 14:1\u20136, 1992","journal-title":"J Hepatol"},{"key":"296457_CR13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0168-8278(92)90065-W","volume":"15","author":"HC Mitchison","year":"1992","unstructured":"Mitchison HC, Palmer JM, Bassendine MF, Watson AJ, Record CO, James OFW: A controlled trial of prednisolone treatment in primary biliary cirrhosis. Three-year results. J Hepatol 15:336\u2013344, 1992","journal-title":"J Hepatol"},{"key":"296457_CR14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0002-9610(91)90080-W","volume":"162","author":"P. J. Duncan","year":"1991","unstructured":"Duncan Phillips J, Stelzner M, Zeng H, Kelly RE, Fonkalsrud EW: Alterations in gastrointestinal motility during postoperative acute corticosteroid withdrawal. Am J Surg 162:251\u2013255, 1991","journal-title":"Am J Surg"},{"key":"296457_CR15","first-page":"84","volume":"44","author":"FH Wolfhagen","year":"1994","unstructured":"Wolfhagen FH, van Buuren HR, Schalm SW: Combined treatment with ursodeoxycholic acid and prednisone in primary biliary cirrhosis. Neth J Med 44:84\u201390, 1994","journal-title":"Neth J Med"},{"key":"296457_CR16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0168-8278(96)80327-8","volume":"25","author":"M Leuschner","year":"1996","unstructured":"Leuschner M, Guldutuna S, You T, Hubner K, Bhatti S, Leuschner U: Ursodeoxycholic acid and prednisolone versus ursodeoxycholic acid and placebo in the treatment of early stages of primary biliary cirrhosis. J Hepatol 25:49\u201357, 1996","journal-title":"J Hepatol"},{"key":"296457_CR17","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S0016-5085(72)80089-1","volume":"62","author":"SM Grundy","year":"1972","unstructured":"Grundy SM, Metzger AL: A physiological method for estimation of hepatic secretion of biliary lipids in man. Gastroenterology 62:1200\u20131217, 1972","journal-title":"Gastroenterology"},{"key":"296457_CR18","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/hep.1840150617","volume":"15","author":"G Mazzella","year":"1992","unstructured":"Mazzella G, Parini P, Festi D, Bazzoli F, Aldini R, Roda A, Tonelli D, Cipolla A, Salzetta A, Roda E: Effect of simvastatin, ursodeoxycholic acid, and simvastatin and ursodeoxycholic acid on biliary lipid secretion and cholic acid kinetics in non-familial hype rcholesterolemia. Hepatology 15:1072\u20131078, 1992","journal-title":"Hepatology"},{"key":"296457_CR19","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.3109\/00365529008998558","volume":"25","author":"G Mazzella","year":"1990","unstructured":"Mazzella G, Bazzoli F, Villanova N, Simoni P, Festi D, Roda A, Aldini R, Roda E: Effect of gemfibrozil administration on biliary lipid secretion in hyperlipidemic patients: A crossover study with clofibrate. Scand J Gastroenterol 25:1227\u20131234, 1990","journal-title":"Scand J Gastroenterol"},{"key":"296457_CR20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0009-8981(75)90364-2","volume":"64","author":"A Roda","year":"1975","unstructured":"Roda A, Festi D, Sama C, Mazzella G, Aldini R, Roda E, Barbara L: Enzymatic determination of cholesterol in bile. Clin Chim Acta 64:377\u2013381, 1975","journal-title":"Clin Chim Acta"},{"key":"296457_CR21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/9780470110249.ch3","volume":"8","author":"P Talalay","year":"1960","unstructured":"Talalay P: Enzymatic analysis of steroid hormones. Methods Biochem Ann 8:119\u2013143, 1960","journal-title":"Methods Biochem Ann"},{"key":"296457_CR22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.0954-6820.1961.tb17091.x","volume":"169","author":"A Svamborg","year":"1961","unstructured":"Svamborg A, Svennerholm M: Plasma total lipid cholesterol, tryglice rides, phospholipids and free fatty acids in healthy scandinavian population. Acta Med Scand 169:43\u201349, 1961","journal-title":"Acta Med Scand"},{"key":"296457_CR23","first-page":"26","volume-title":"Standard Methods of Clinical Chemistry","author":"LL Abell","year":"1958","unstructured":"Abell LL, Levy BB, Bride BB. Cholesterol in serum. In Standard Methods of Clinical Chemistry, Vol 2. D Saligson (ed). New York, Academic Press, 1958, pp 26\u201333"},{"key":"296457_CR24","first-page":"139","volume":"22","author":"S Hyden","year":"1955","unstructured":"Hyden S: A turbidimetric method for determination of higher polyethylenglycols in biological materials. Ann R Agric Coll Swed 22:139\u2013149, 1955","journal-title":"Ann R Agric Coll Swed"},{"key":"296457_CR25","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0022-2275(20)40553-X","volume":"33","author":"A Roda","year":"1992","unstructured":"Roda A, Cerr\u00e9 C, Simoni P, Polimeni C, Vaccari C, Pistillo A: Determination of free and amidated bile acids by HPLC with evaporative light-scattering mass dete ction. J Lipid Res 33:1393\u20131402, 1992","journal-title":"J Lipid Res"},{"key":"296457_CR26","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1172\/JCI109025","volume":"61","author":"MC Carey","year":"1978","unstructured":"Carey MC, Small DM: The physical chemistry of cholesterol solubility in bile: Relationship to gallstone formation and dissolution in man. J Clin Invest 61:998\u20131026, 1978","journal-title":"J Clin Invest"},{"key":"296457_CR27","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0022-2275(20)40677-7","volume":"19","author":"MC Carey","year":"1978","unstructured":"Carey MC: Critical tables for calculating the cholesterol saturation of native bile. J Lipid Res 19:945\u2013955, 1978","journal-title":"J Lipid Res"},{"key":"296457_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.1957.tb01473.x","volume":"40","author":"S Lindstedt","year":"1957","unstructured":"Lindstedt S: The turnover of cholic acid in man. Acta Physiol Scand 40:1\u20139, 1957","journal-title":"Acta Physiol Scand"},{"key":"296457_CR29","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/S0022-2275(20)34446-1","volume":"25","author":"F Stellaard","year":"1984","unstructured":"Stellaard F, Sackmann M, Sauerbruch T, Paumgartner G: Simultaneous determination of cholic acid and chenodeoxycholic acid pool sizes and fractional turnover serum in human se rum using 13C-labeled bile acids. J Lipid Res 25:1313\u20131319, 1984","journal-title":"J Lipid Res"},{"key":"296457_CR30","volume-title":"Primer of Biostatistics","author":"SA Glantz","year":"1987","unstructured":"Glantz SA: Primer of Biostatistics. New York, McGraw-Hill, 1987"},{"key":"296457_CR31","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/gut.37.3.301","volume":"37","author":"AG Lim","year":"1995","unstructured":"Lim AG, Jazrawi RP, Northfield TC: The ursodeoxycholic acid story in primary biliary cirrhosis. Gut 37:301\u2013304, 1995","journal-title":"Gut"},{"key":"296457_CR32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/bj2620341","volume":"262","author":"HMG Princen","year":"1989","unstructured":"Princen HMG, Meijer P, Hofstee B: Dexame thasone regulated bile acid synthe sis in monolayer cultures of rat hepatocytes by induction of cholesterol 7\u03b1-hydroxylase. Biochem J 262:341\u2013348, 1989","journal-title":"Biochem J"},{"key":"296457_CR33","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1055\/s-2008-1040410","volume":"12","author":"ZR Vlahcevic","year":"1992","unstructured":"Vlahcevic ZR, Pandack WM, Heuman DM, Hylemon PB: Function and regulation of hydroxylases involved in the bile acid biosynthesis pathways. Semin Liver Dis 12:403\u2013419, 1992","journal-title":"Semin Liver Dis"},{"key":"296457_CR34","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1172\/JCI111459","volume":"74","author":"N Carulli","year":"1984","unstructured":"Carulli N, Loria P, Bertolotti M, Ponz de Leon M, Menozzi D, Medici G, Piccagli I: Effects of acute changes of bile acid pool composition on biliary lipid secretion. J Clin Invest 74:614\u2013624, 1984","journal-title":"J Clin Invest"},{"key":"296457_CR35","doi-asserted-by":"crossref","first-page":"52S","DOI":"10.1007\/BF01536664","volume":"34","author":"E Roda","year":"1989","unstructured":"Roda E, Mazzella G, Bazzoli F, Villanova N, Minutello A, Simoni P, Ronchi M, Poggi C, Festi D, Aldini R, Roda A: Effect of ursodeoxycholic acid administration on biliary lipid secretion in primary biliary cirrhosis. Dig Dis Sci 34: 52S-58S, 1989","journal-title":"Dig Dis Sci"},{"key":"296457_CR36","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1007\/BF01295917","volume":"38","author":"G Mazzella","year":"1993","unstructured":"Mazzella G, Parini P, Bazzoli F, Villanova N, Festi D, Aldini R, Roda A, Cipolla A, Polimeni C, Tonelli D, Roda E: Ursode-oxycholic acid administration on bile acid metabolism in patients with early stages of primary biliary cirrhosis. Dig Dis Sci 38:896\u2013902, 1993","journal-title":"Dig Dis Sci"},{"key":"296457_CR37","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1136\/gut.19.7.640","volume":"19","author":"E Roda","year":"1978","unstructured":"Roda E, Aldini R, Mazzella G, Roda A, Sama C, Festi D, Barbara L: Enterohepatic circulation of bile acids after cholecystectomy. Gut 19:640\u2013649, 1978","journal-title":"Gut"},{"key":"296457_CR38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00315387","volume":"45","author":"S Guldutuna","year":"1993","unstructured":"Guldutuna S, Leuschner M, Wunderlich N, Nickel A, Bhatti S, Hubner K, Leuschener U: Cholic acid and ursodeoxycholic acid therapy in primary biliary cirrhosis. Changes in bile acid patterns and their correlation with liver function. Eur J Clin Pharmacol 45:221\u2013225, 1993","journal-title":"Eur J Clin Pharmacol"},{"key":"296457_CR39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1136\/gut.27.5.550","volume":"27","author":"SN Marcus","year":"1986","unstructured":"Marcus SN, Heaton KW: Intestinal Transit, deoxycholic acid and the cholesterol saturation of bile\u00d0 three interre lated factors. Gut 27:550\u2013558, 1986","journal-title":"Gut"},{"key":"296457_CR40","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1172\/JCI115961","volume":"90","author":"F Barr","year":"1992","unstructured":"Barr F, Pratschke E, Fisher S, Paumgartner G: Disorde rs of bile acid metabolism in cholesterol gallstone disease. J Clin Invest 90:859\u2013868, 1992","journal-title":"J Clin Invest"},{"key":"296457_CR41","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1365-2362.1979.tb00921.x","volume":"9","author":"B Angelin","year":"1977","unstructured":"Angelin B, Einarsson K, Leijd B: Biliary lipid composition during treatment with different hypolipidaemic drugs. Eur J Clin Invest 9:185\u2013190, 1977","journal-title":"Eur J Clin Invest"},{"key":"296457_CR42","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2796.1991.tb00338.x","volume":"229","author":"M Carrella","year":"1991","unstructured":"Carrella M, Ericsson S, Del Piano C, Angelin B, Einarsson K: Effect of cholestyramine treatment on biliary lipid secretion rated in normolipidaemic men. J Int Med 229:241\u2013246, 1991","journal-title":"J Int Med"},{"key":"296457_CR43","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0026-0495(88)90067-4","volume":"37","author":"WH Ettinger Jr","year":"1988","unstructured":"Ettinger WH Jr, Hazzard WR: Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men. Metabolism 37:1055\u20131058, 1988","journal-title":"Metabolism"},{"key":"296457_CR44","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/pgmj.56.657.491","volume":"56","author":"DB Jefferys","year":"1980","unstructured":"Jefferys DB, Lessof MH, Mattock MB: Corticosteroid treatment, serum lipids and coronary artery disease. Postgrad Med 56:491\u2013493, 1980","journal-title":"Postgrad Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026687022202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1026687022202\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1026687022202.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:13:59Z","timestamp":1752462839000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1026687022202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["296457"],"URL":"https:\/\/doi.org\/10.1023\/a:1026687022202","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}