{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:35:38Z","timestamp":1790854538193,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Inflammation"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1023\/a:1027315814817","type":"journal-article","created":{"date-parts":[[2003,11,9]],"date-time":"2003-11-09T22:46:39Z","timestamp":1068417999000},"page":"541-551","source":"Crossref","is-referenced-by-count":17,"title":["Staphylococcal Culture Supernates Stimulate Human Phagocytes"],"prefix":"10.1007","volume":"21","author":[{"given":"Karin Ellen","family":"Veldkamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kok P. M.","family":"Van Kessel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Verhoef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos A. G.","family":"Van Strijp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"426090_CR1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1001\/archinte.1994.00420010044006","volume":"154","author":"R. C. Bone","year":"1994","unstructured":"BONE, R. C. 1994. Gram-positive organisms and sepsis. Arch. Intern. Med.\n154:26\u201334.","journal-title":"Arch. Intern. Med."},{"key":"426090_CR2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/00003246-198906000-00001","volume":"17","author":"J. M. H. Debets","year":"1989","unstructured":"DEBETS, J. M. H., R. KAMPMEIJER, M. P. M. H. VAN DER\nLINDEN, W. A. BUURMAN, and C. J. VAN DER\nLINDEN. 1989. Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit. Care Med.\n17:489\u2013494.","journal-title":"Crit. Care Med."},{"key":"426090_CR3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1164\/ajrccm\/141.1.94","volume":"141","author":"J. D. Marks","year":"1990","unstructured":"MARKS, J. D., C. BERMAN MARKS, J. M. LUCE, A. B. MONTGOMERY, J. TURNE, C. A. METZ, and J. F. MURRAY. 1990. Plasma tumor necrosis factor in patients with septic shock. American Rev. Respir. Dis.\n141:94\u201397.","journal-title":"American Rev. Respir. Dis."},{"key":"426090_CR4","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1128\/iai.62.9.3837-3843.1994","volume":"62","author":"E. Mattsson","year":"1994","unstructured":"MATTSSON, E., J. ROLLOF, J. VERHOEF, H. VAN DIJK, and A. FLEER. 1994. Serum-induced potentiation of tumor necrosis factor alpha production by human monocytes in response to staphylococcal peptidoglycan: involvement of different serum factors. Infect. Immun.\n62:3837\u20133843.","journal-title":"Infect. Immun."},{"key":"426090_CR5","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.1128\/iai.61.10.4167-4172.1993","volume":"61","author":"C. P. Tlmmerman","year":"1993","unstructured":"TLMMERMAN, C. P., E. MATTSSON, L. MARTINEZ\nMARTINEZ, L. DE\nGRAAF, J. A. VAN\nSTRIJP, H. A. VERBRUGH, J. VERHOEF, and A. FLEER. 1993. Induction of release of tumor necrosis factor from human monocytes by staphylococci and staphylococcal peptidoglycans. Infect. Immun.\n61:4167\u20134172.","journal-title":"Infect. Immun."},{"key":"426090_CR6","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1128\/iai.62.7.2715-2721.1994","volume":"62","author":"D. Heumann","year":"1994","unstructured":"HEUMANN, D., C. BARRAS, A. SEVERIN, M. P. GLAUSER, and A. TOMASZ. 1994. Gram-positive cell walls stimulate synthesis of tumor necrosis factor alpha and interleukin-6 by human monocytes. Infect. Immun.\n62:2715\u20132721.","journal-title":"Infect. Immun."},{"key":"426090_CR7","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1128\/iai.60.9.3664-3672.1992","volume":"60","author":"R. Keller","year":"1992","unstructured":"KELLER, R., W. FISCHER, R. KEIST, and S. BASSETTI. 1992. Macrophage response to bacteria: induction of marked secretory and cellular activities by lipoteichoic acids. Infect. Immun.\n60:3664\u20133672.","journal-title":"Infect. Immun."},{"key":"426090_CR8","doi-asserted-by":"crossref","first-page":"4614","DOI":"10.1128\/iai.59.12.4614-4620.1991","volume":"59","author":"S. Bhakdi","year":"1991","unstructured":"BHAKDI, S., T. KLONISCH, P. NUBER, and W. FISCHER. 1991. Stimulation of monokine production by lipoteichoic acids. Infect. Immun.\n59:4614\u20134620.","journal-title":"Infect. Immun."},{"key":"426090_CR9","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.4049\/jimmunol.155.5.2620","volume":"155","author":"D. Gupta","year":"1995","unstructured":"GUPTA, D., Y. P. JIN, and R. DZIARSKI. 1995. Peptidoglycan induces transcription and secretion of TNF-alpha and activation of lyn, extracellular signal-regulated kinase, and rsk signal transduction proteins in mouse macrophages. J. Immunol.\n155:2620\u20132630.","journal-title":"J. Immunol."},{"key":"426090_CR10","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1126\/science.2185544","volume":"248","author":"P. Marrack","year":"1990","unstructured":"MARRACK, P., and J. KAPPLER. 1990. The staphylococcal enterotoxins and their relatives. Science\n248:705\u2013711.","journal-title":"Science"},{"key":"426090_CR11","first-page":"229","volume":"61","author":"D. L. Murray","year":"1995","unstructured":"MURRAY, D. L., D. H. OHLENDORF, and P. M. SCHLIEVERT. 1995. Staphylococcal and streptococcal superantigens: Their role in human diseases. ASM News\n61:229\u2013235.","journal-title":"ASM News"},{"key":"426090_CR12","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1128\/iai.60.8.3456-3459.1992","volume":"60","author":"R. H. See","year":"1992","unstructured":"SEE, R. H., and A. W. CHOW. 1992. Straphylococcal toxic shock syndrome toxin-1 induced humor necrosis factor alpha and interleukin-1 beta secretion by human peripheral blood monocytes and T lymphocytes is differentially suppressed by protein kinase inhibitors. Infect. Immun.\n60:3456\u20133459.","journal-title":"Infect. Immun."},{"key":"426090_CR13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1099\/00222615-42-4-237","volume":"42","author":"G. Pr\u00c9vost","year":"1995","unstructured":"PR\u00c9VOST, G., P. COUPPIE, P. PR\u00c9VOST, S. GAYET, P. PETIAU, B. CRIBIER, H. MONTEIL, and Y, PIEMONT. 1995. Epidemiological data on Staphylococcus aureus strains producing synergo-hymenotropic toxins. J. Med. Microbiol.\n42:237\u2013245.","journal-title":"J. Med. Microbiol."},{"key":"426090_CR14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/infdis\/171.3.607","volume":"171","author":"B. K\u00d6nig","year":"1995","unstructured":"K\u00d6NIG, B., G. PR\u00c9VOST, Y. PIEMONT, and W. K\u00d6NIG. 1995. Effects of Staphylococcus aureus leukocidins on inflammatory mediator release from human granulocytes. J. Infect. Dis.\n171:607\u2013613.","journal-title":"J. Infect. Dis."},{"key":"426090_CR15","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1128\/iai.58.6.1653-1659.1990","volume":"58","author":"S. Kasimir","year":"1990","unstructured":"KASIMIR, S., W. SCH\u00d6NFELD, J. E. ALOUF, and W. K\u00d6NIG. 1990. Effect of Staphylococcus aureus delta-toxin on human granulocyte functions. Infect. Immun.\n58:1653\u20131659.","journal-title":"Infect. Immun."},{"key":"426090_CR16","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1128\/iai.57.11.3512-3519.1989","volume":"57","author":"S. Bhakdi","year":"1989","unstructured":"BHAKDI, S., M. MUHLY, S. KOROM, and F. HUGO. 1989. Release of interleukin-1 beta associated with potent cytocidal action of. Infect. Immun.\n57:3512\u20133519.","journal-title":"Infect. Immun."},{"key":"426090_CR17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1172\/JCI108971","volume":"61","author":"P. K. Peterson","year":"1978","unstructured":"PETERSON, P. K., B. J. WILKINSON, Y. KIM, D. SCHMELING, S. D. DOUGLAS, and P. G. QUIE. 1978. The key role of peptidoglycan in the opsonisation of Staphylococcus Aureus. J. Clin. Invest.\n61:597\u2013609.","journal-title":"J. Clin. Invest."},{"key":"426090_CR18","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1128\/iai.20.2.388-392.1978","volume":"20","author":"B. J. Wilkinson","year":"1978","unstructured":"WILKINSON, B. J., Y. KIM, P. K. PETERSON, P. G. QUIE, and A. F. MICHAEL. 1978. Activation of complement by cell surface components of Staphylococcus aureus. Infect. Immun.\n20:388\u2013392.","journal-title":"Infect. Immun."},{"key":"426090_CR19","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1128\/iai.26.1.57-63.1979","volume":"26","author":"D. J. Schmeling","year":"1979","unstructured":"SCHMELING, D. J., P. K. PETERSON, D. E. HAMMERSCHMIDT, Y. KIM, J. VERHOEF, B. J. WILKINSON, and P. G. QUIE. 1979. Chemotaxigenesis by cell surface components of Staphylococcus aureus. Infect. Immun.\n26:57\u201363.","journal-title":"Infect. Immun."},{"key":"426090_CR20","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1128\/iai.37.3.1112-1118.1982","volume":"37","author":"A. R. Zeiger","year":"1982","unstructured":"ZEIGER, A. R., W. WONG, A. N. CHATTERJEE, F. E. YOUNG, and C. U. TUAZON. 1982. Evidence for the secretion of soluble peptidoglycans by clinical isolates. Infect. Immun.\n37:1112\u20131118.","journal-title":"Infect. Immun."},{"key":"426090_CR21","first-page":"397","volume":"4","author":"K. Bayston","year":"1992","unstructured":"BAYSTON, K., M. TOMLINSON, and J. COHEN. 1992. In-vitro stimulation of TNF-alpha from human whole blood by cell-free supernatants of Gram-positive bacteria. Cylokine\n4:397\u2013402.","journal-title":"Cylokine"},{"key":"426090_CR22","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1128\/iai.62.11.4709-4715.1994","volume":"62","author":"B. Weidemann","year":"1994","unstructured":"WEIDEMANN, B., H. BRADE, E. T. RIETSCHEL, R. DZIARSKI, V. BAZIL, S. KUSUMOTO, H. D. FLAD,, and A. J. ULMER. 1994. Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures. Infect. Immun.\n62:4709\u2013715.","journal-title":"Infect. Immun."},{"key":"426090_CR23","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.182.6.1673","volume":"182","author":"T. Kusunoki","year":"1995","unstructured":"KUSUNOKI, T., E. HAILMAN, T. S. C. JUAN, H. S. LICHTENSTEIN, and S. D. WRIGHT. 1995. Molecules from Staphylococcus aureus that bind CD14 and stimulate innate immune responses. J. Exp. Med.\n182:1673\u20131682.","journal-title":"J. Exp. Med."},{"key":"426090_CR24","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1016\/S0021-9258(20)81980-2","volume":"258","author":"S. Bhakdi","year":"1983","unstructured":"BHAKDI, S., R. F\u00dcSSLE, G. UTERMANN, and J. TRANUM-JENSEN. 1983. Binding the partial inactivation of S. aureus a-toxin by humam plasma low density lipoprotein. J. Biol. Chem.\n258:5899\u20135904.","journal-title":"J. Biol. Chem."},{"key":"426090_CR25","first-page":"619","volume-title":"Staphylococci and Staphylococcal Infections","author":"R. M\u00d6llby","year":"1983","unstructured":"M\u00d6LLBY, R. 1983. Isolation and properties of membrane damaging toxins. In Staphylococci and Staphylococcal Infections. C. S. F. Easmon and C. Adlam, editors. Academic Press Ltd, London. 619\u2013669."},{"key":"426090_CR26","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1432-1033.1991.tb15696.x","volume":"195","author":"E. Thiaudiere","year":"1991","unstructured":"THIAUDIERE, E., O. SIFFERT, J. C. TALBOT, J. BOLARD, J. E. ALOUF, and J. DUFOURCQ. 1991. The amphiphilic alpha helix concept. Consequences on the structure of staphylococcal delta-toxin in solution and bound to lipids. Ear. J. Biochem.\n195:203\u2013213.","journal-title":"Ear. J. Biochem."}],"container-title":["Inflammation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1027315814817.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1027315814817\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1027315814817.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T12:58:41Z","timestamp":1748264321000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1027315814817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["426090"],"URL":"https:\/\/doi.org\/10.1023\/a:1027315814817","relation":{},"ISSN":["0360-3997","1573-2576"],"issn-type":[{"value":"0360-3997","type":"print"},{"value":"1573-2576","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}