{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:47:35Z","timestamp":1762112855037,"version":"3.41.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1997,1,1]],"date-time":"1997-01-01T00:00:00Z","timestamp":852076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[1997,1]]},"DOI":"10.1023\/a:1027337606929","type":"journal-article","created":{"date-parts":[[2003,11,9]],"date-time":"2003-11-09T22:46:39Z","timestamp":1068417999000},"page":"87-92","source":"Crossref","is-referenced-by-count":24,"title":["Melatonin Effects on Serotonin Synthesis and Metabolism in the Striatum, Nucleus Accumbens, and Dorsal and Median Raphe Nuclei of Rats"],"prefix":"10.1007","volume":"22","author":[{"given":"Jes\u00fas M.","family":"M\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Aldegunde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"425712_CR1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1210\/edrv-12-2-151","volume":"12","author":"R. J. Reiter","year":"1991","unstructured":"Reiter, R. J. 1991. Pineal melatonin: cell biology of its synthesis and of its physiological interactions. Endocrine Rev. 12:151\u2013180.","journal-title":"Endocrine Rev."},{"key":"425712_CR2","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.6823571","volume":"219","author":"J. R. Redman","year":"1983","unstructured":"Redman, J. R., Armstrong, S. M., and Ng, K. T. 1983. Free running activity rhythms in the rat. Entrainment by melatonin. Science 219:1089\u20131091.","journal-title":"Science"},{"key":"425712_CR3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0022-3565(25)22029-8","volume":"227","author":"D. Sugden","year":"1983","unstructured":"Sugden, D. 1983. Phychopharmacological effects of melatonin in mouse and rat. J. Pharmacol. Exp. Ther. 227:587\u2013591.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"425712_CR4","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2165\/00023210-199503030-00006","volume":"3","author":"G. M. Brown","year":"1995","unstructured":"Brown, G. M. 1995. Melatonin in psychiatric and sleep disorders. CNS Drugs 3:209\u2013226.","journal-title":"CNS Drugs"},{"key":"425712_CR5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2265.1995.tb01869.x","volume":"42","author":"S. M. Webb","year":"1995","unstructured":"Webb, S. M., and Puig-Domingo, M. 1995. Role of melatonin in health and disease. Clin. Endocrinol. 42:221\u2013234.","journal-title":"Clin. Endocrinol."},{"key":"425712_CR6","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1159\/000125066","volume":"48","author":"M. Laudon","year":"1988","unstructured":"Laudon, M., Nir, I. and Zisapel, N. 1988. Melatonin receptors in discrete brain areas of the male rat. Neuroendocrinology 48:577\u2013583.","journal-title":"Neuroendocrinology"},{"key":"425712_CR7","first-page":"277","volume-title":"The Pineal Gland and its Endocrine Role","author":"D. P. Cardinali","year":"1985","unstructured":"Cardinali, D. P., Vacas, M. I., Keller-Sarmiento, M. I., and Morguenstern, E. 1985. Melatonin action: sites and possible mechanisms in brain, Pages 277\u2013302, in Axelrod, J., Fraschini, F., and Velo, G. P. (eds.), The Pineal Gland and its Endocrine Role, Plenum Press, New York."},{"key":"425712_CR8","first-page":"159","volume-title":"Advances in Pineal Research","author":"C. Ruzs\u00e1s","year":"1986","unstructured":"Ruzs\u00e1s, C., Fraschini, F., Peschke, E., Esposti, D., and Esposti, G. 1986. Brain neurotransmitters mediating neuroendocrine activity of melatonin. Pages 159\u2013166, in Reiter, R. J., and Karasek, M. (eds.), Advances in Pineal Research, John Libbey & Co Ltd, London."},{"key":"425712_CR9","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0304-3940(89)90596-X","volume":"104","author":"C. Dugovic","year":"1989","unstructured":"Dugovic, C., Leysen, J. E., and Wauquier, A. 1989. Melatonin modulates the sensitivity of 5-hydroxytryptamine-2 receptor-mediated sleep-wakefulness regulation in the rat. Neurosci. Lett. 104:320\u2013325.","journal-title":"Neurosci. Lett."},{"key":"425712_CR10","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0022-3565(25)09543-6","volume":"273","author":"A. S. Eison","year":"1995","unstructured":"Eison, A. S., Freeman, R. P., Guss, V. B., Mullins, U. L., and Wright, R. N. 1995. Melatonin agonists modulate 5-HT2A receptor-mediated neurotransmission: behavioral and biochemical studies in the rat. J. Pharmacol. Exp. Ther. 273:304\u2013308.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"425712_CR11","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0028-3908(85)90080-2","volume":"24","author":"O. Gaffori","year":"1985","unstructured":"Gaffori, O., and Van Ree, J. M. 1985. Serotonin and antidepressant drugs antagonize melatonin-induced behavioral changes after injection into the nucleus accumbens of rats. Neuropharmacology 24:237\u2013244.","journal-title":"Neuropharmacology"},{"key":"425712_CR12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1600-079X.1991.tb00459.x","volume":"11","author":"J. M. M\u00edguez","year":"1991","unstructured":"M\u00edguez, J. M., Mart\u00edn, F. J., M\u00edguez, I., and Aldegunde, M. 1991. Long-term pinealectomy alters hypothalamic serotonin metabolism in the rat. J. Pineal Res. 11:75\u201379.","journal-title":"J. Pineal Res."},{"key":"425712_CR13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-079X.1994.tb00129.x","volume":"17","author":"J. M. M\u00edguez","year":"1994","unstructured":"M\u00edguez, J. M., Mart\u00edn, F. J., and Aldegunde, M. 1994. Effects of single and daily melatonin treatments on serotonin metabolism in rat brain regions. J. Pineal Res. 17:170\u2013176.","journal-title":"J. Pineal Res."},{"key":"425712_CR14","doi-asserted-by":"crossref","unstructured":"M\u00edguez, J. M., Mart\u00edn, F. J., Lema, M., and Aldegunde, M. 1996. Changes in serotonin level and turnover in discrete hypothalamic nuclei after pinealectomy and melatonin administration to rats. Neurochem. Int. In press.","DOI":"10.1016\/S0197-0186(96)00028-9"},{"key":"425712_CR15","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/BF00995374","volume":"20","author":"J. M. M\u00edguez","year":"1995","unstructured":"M\u00edguez, J. M., Mart\u00edn, F. J., and Aldegunde, M. 1995. Effects of pinealectomy and melatonin treatments on serotonin uptake and release from synaptosomes of rat hypothalamic regions. Neurochem. Res. 20:1127\u20131132.","journal-title":"Neurochem. Res."},{"key":"425712_CR16","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","volume":"72","author":"B. L. Jacobs","year":"1992","unstructured":"Jacobs, B. L., and Azmitia, E. A. 1992. Structure and function of the brain serotoninergic system. Physiol. Rev. 72:165\u2013229.","journal-title":"Physiol. Rev."},{"key":"425712_CR17","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0028-3908(81)90038-1","volume":"20","author":"D. L. Jones","year":"1981","unstructured":"Jones, D. L., Mogenson, G. J., and Wu, M. 1981. Injections of dopaminergic, cholinergic, serotoninergic and GABAergic drugs into the nucleus accumbens: effects on locomotor activity in the rat. Neuropharmacology 20:2\u201337.","journal-title":"Neuropharmacology"},{"key":"425712_CR18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1600-079X.1993.tb00522.x","volume":"15","author":"J. L. Castillo-Romero","year":"1993","unstructured":"Castillo-Romero, J. L., Vives-Montero, F., Reiter, R. J., and Acu\u00f1a-Castroviejo, D. 1993. Pineal modulation of the rat caudate-putamen spontaneous neuronal activity: roles of melatonin and vasotocin. J. Pineal Res. 15:147\u2013152.","journal-title":"J. Pineal Res."},{"key":"425712_CR19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0031-9384(73)90132-7","volume":"11","author":"D. K. Bliss","year":"1973","unstructured":"Bliss, D. K., and Bates, P. L. 1973. A rapid and reliable technique for pinealectomising rats. Physiol. Behav. 11:111\u2013112.","journal-title":"Physiol. Behav."},{"key":"425712_CR20","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/0006-8993(73)90290-4","volume":"59","author":"M. Palkovits","year":"1973","unstructured":"Palkovits, M. 1973. Isolated removal of hypothalamic or other brain nuclei of the rat. Brain Res. 59:449\u2013450.","journal-title":"Brain Res."},{"key":"425712_CR21","first-page":"23","volume-title":"Handbook of Chemical Neuroanatomy, Volumen 2, Classical Transmitters in the CNS","author":"M. J. Brownstein","year":"1984","unstructured":"Brownstein, M. J., and Palkovits, M. 1984. Catecholamines, serotonin, acetylcholine, and \u03b3-aminobutyric acid in the rat brain: biochemical studies, Pages 23\u201354, in Bj\u00f6rklund, A., and H\u00f6kfelt, T. (eds.), Handbook of Chemical Neuroanatomy, Volumen 2, Classical Transmitters in the CNS, Part 1, Elsevier, Amsterdam."},{"key":"425712_CR22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M. M. Bradford","year":"1976","unstructured":"Bradford, M. M. 1976. A raid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal. Biochem. 72:248\u2013254.","journal-title":"Anal. Biochem."},{"key":"425712_CR23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF00229997","volume":"85","author":"F. Houdouin","year":"1991","unstructured":"Houdouin, F., Cespuglio, R., Gharib, A., Sarda, N., and Jouvet, M. 1991. Detection of the release of 5-hydroxyindole compounds in the hypothalamus and n. raphe dorsalis throughout the sleep-waking cycle and during stressful situation in the rat: a polygraphic and voltammetric approach. Exp. Brain Res. 85:153\u2013162.","journal-title":"Exp. Brain Res."},{"key":"425712_CR24","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/BF00166940","volume":"347","author":"P. Celada","year":"1993","unstructured":"Celada, P., and Artigas, F. 1993. Effects of local and systemic MAO inhibitors on extracellular brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the frontal cortex and raphe nuclei of freely moving rats. An in vivo microdialysis study. Naunyn-Schmiedeberg's Arch. Pharmacol. 347:583\u2013590.","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"425712_CR25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000121744","volume":"4","author":"I. Nir","year":"1969","unstructured":"Nir, I., Behroozi, K., Assael, M., Ivriani, I., and Sulman, F. G. 1969. Changes in electrical activity of the brain following pinealectomy. Neuroendocrinology 4:122\u2013127.","journal-title":"Neuroendocrinology"},{"key":"425712_CR26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0006-2952(83)90678-0","volume":"32","author":"M. C. Boadle-Biber","year":"1983","unstructured":"Boadle-Biber, M. C., Johannessen, J. N., Narasimhachari, N., and Phan, T. H. 1983. Activation of tryptophan hydroxylase by stimulation of central serotoninergic neurons. Biochem. Pharmacol. 32:185\u2013188.","journal-title":"Biochem. Pharmacol."},{"key":"425712_CR27","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/BF02358834","volume":"31","author":"R. L. Urry","year":"1975","unstructured":"Urry, R. L., and Ellis, L. C. 1975. Monoamine oxidase activity of the hypothalamus and pituitary: alterations after pinealectomy, changes in photoperiod, or additions of melatonin in vitro. Experientia 31:891\u2013892.","journal-title":"Experientia"},{"key":"425712_CR28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000122385","volume":"18","author":"D. P. Cardinali","year":"1975","unstructured":"Cardinali, D. P., Nagle, C. A., Freire, F., and Rosner, J. M. 1975. Effects of melatonin on neurotransmitter uptake and release by synaptosome-rich homogenates of the rat hypothalamus. Neuroendocrinology 18:72\u201385.","journal-title":"Neuroendocrinology"},{"key":"425712_CR29","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000125851","volume":"54","author":"N. A. Alexiuk","year":"1991","unstructured":"Alexiuk, N. A., and Vriend, J. 1991. Effects of daily afternoon melatonin administration on monoamine accumulation in median eminence and striatum of ovariectomized hamsters receiving pargyline. Neuroendocrinology 54:55\u201361.","journal-title":"Neuroendocrinology"},{"key":"425712_CR30","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1007\/BF00965929","volume":"14","author":"W. B. Quay","year":"1989","unstructured":"Quay, W. B. 1989. Changes with darkness in regional brain 5-hydroxytryptamine and 5-hydroxyindole acetic acid: local differences with pinealectomy, sham surgery, and melatonin. Neurochem. Res. 14:957\u2013961.","journal-title":"Neurochem. Res."},{"key":"425712_CR31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0304-3940(80)90010-5","volume":"16","author":"D. L. Felten","year":"1980","unstructured":"Felten, D. L., and Harrigan, P. 1980. Dendrite bundles in nuclei raphe dorsalis and centralis superior of the rabbit: a possible substrate for local control of serotonergic neurons. Neurosci. Lett. 16:275\u2013280.","journal-title":"Neurosci. Lett."},{"key":"425712_CR32","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/BF00965589","volume":"11","author":"J. Pecci-Saavedra","year":"1986","unstructured":"Pecci-Saavedra, J., Brusco, A., Peressine, S., and Oliva, D. 1986. A new case for a presynaptic role of dendrites: an immunocy-toachemical study of the N. raph\u00e9 dorsalis. Neurochem. Res. 11:997\u20131009.","journal-title":"Neurochem. Res."},{"key":"425712_CR33","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(85)90856-X","volume":"346","author":"A. Pazos","year":"1985","unstructured":"Pazos, A., and Palacios, J. M. 1985. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346:205\u2013230.","journal-title":"Brain Res."},{"key":"425712_CR34","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1016\/0024-3205(91)90216-X","volume":"48","author":"S. Hjorth","year":"1991","unstructured":"Hjorth, S., and Sharp, T. 1991. Effect of the 5-HT1A receptors agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis. Life Sci. 48:1779\u20131786.","journal-title":"Life Sci."},{"key":"425712_CR35","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0166-2236(90)90107-L","volume":"13","author":"G. E. Alexander","year":"1990","unstructured":"Alexander, G. E., and Crutcher, M. D. 1990. Functional architecture of basal ganglia circuits: neural sustrates of parallel processing. Trends Neurosci. 13:266\u2013271.","journal-title":"Trends Neurosci."},{"key":"425712_CR36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/333174a0","volume":"333","author":"S. Nedergaard","year":"1988","unstructured":"Nedergaard, S., Bolam, J. P., and Grennfield, S. A. 1988. Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra. Nature 333:174\u2013177.","journal-title":"Nature"},{"key":"425712_CR37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(93)90984-U","volume":"606","author":"L. H. Parsons","year":"1993","unstructured":"Parsons, L. H., and Justice, J. B. 1993. Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis. Brain Res. 606:195\u2013199.","journal-title":"Brain Res."},{"key":"425712_CR38","first-page":"231","volume-title":"Neuronal serotonin","author":"A. J. Cross","year":"1988","unstructured":"Cross, A. J. 1988. Serotonin in neurodegenerative disorders. Pages 231\u2013253, in Osborne, N. N., and Hamon, M. (eds.), Neuronal serotonin. Wiley. New York."},{"key":"425712_CR39","first-page":"43","volume-title":"Catecholamines: Neuropharmacology and Central Nervous System-Therapeutic aspects","author":"B. Scatton","year":"1984","unstructured":"Scatton, B., Javoy-Agid, F., Montfort, J. C., and Agid, Y. 1984. Neurochemistry of monoaminergic neurons in Parkinson's disease. Pages 43\u201352, in Usdin, E., Carlsson, A., Dahlstr\u00f6m, A., and Engel, J. (eds.), Catecholamines: Neuropharmacology and Central Nervous System-Therapeutic aspects. Alan L. Liss. New York."},{"key":"425712_CR40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0014-2999(92)90505-X","volume":"217","author":"C. Durlach-Nisteli","year":"1992","unstructured":"Durlach-Nisteli, C., and Van Ree, J. M. 1992. Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs. Eur. J. Pharmacol. 217:15\u201321.","journal-title":"Eur. J. Pharmacol."}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1027337606929.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1027337606929\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1027337606929.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T09:21:10Z","timestamp":1749720070000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1027337606929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,1]]}},"alternative-id":["425712"],"URL":"https:\/\/doi.org\/10.1023\/a:1027337606929","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"type":"print","value":"0364-3190"},{"type":"electronic","value":"1573-6903"}],"subject":[],"published":{"date-parts":[[1997,1]]}}}