{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:20:26Z","timestamp":1783956026190,"version":"3.55.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1023\/b:ddas.0000034550.08623.9b","type":"journal-article","created":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T22:48:50Z","timestamp":1089758930000},"page":"925-930","source":"Crossref","is-referenced-by-count":5,"title":["Gastric and Duodenal Mucosal Protein Fractional Synthesis and Growth Factor Expression in Patients with H. pylori-Associated Gastritis Before and After Eradication of the Organism"],"prefix":"10.1007","volume":"49","author":[{"given":"Trevor A.","family":"Winter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Kidd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. N.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"492749_CR1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","volume":"325","author":"J Parsonnet","year":"1991","unstructured":"Parsonnet J, Friedman GD, Vandersteen DP, Chang Y, Vogelman JH, Orentreich N, Sibley RK: Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325: 1127\u20131131, 1991","journal-title":"N Engl J Med"},{"issue":"Suppl","key":"492749_CR2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/00365528809091712","volume":"142","author":"JI Wyatt","year":"1988","unstructured":"Wyatt JI, Rathbone BJ: Immune response of the gastric mucosa to Campylobacter pylori. Scand J Gastroenterol Suppl 142: 44\u201349, 1988","journal-title":"Scand J Gastroenterol"},{"key":"492749_CR3","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0140-6736(91)92035-Z","volume":"338","author":"AC Wotherspoon","year":"1991","unstructured":"Wotherspoon AC, Ortiz-Hidalgo C, Falzon MR, Isaacson PG: Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 338: 1175\u20131176, 1991","journal-title":"Lancet"},{"key":"492749_CR4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0140-6736(93)91408-E","volume":"342","author":"T Hussell","year":"1993","unstructured":"Hussell T, Isaacson PG, Crabtree JE, Spencer J: The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet 342: 571\u2013574, 1993","journal-title":"Lancet"},{"key":"492749_CR5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0140-6736(93)91409-F","volume":"342","author":"AC Wotherspoon","year":"1993","unstructured":"Wotherspoon AC, Doglioni C, Diss TC, Pan L, Moschini A, de Boni M, Isaacson PG: Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 342: 575\u2013577, 1993","journal-title":"Lancet"},{"key":"492749_CR6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00004836-199509000-00011","volume":"21","author":"G Cammarota","year":"1995","unstructured":"Cammarota G, Tursi A, Montalto M, Papa A, Branca G, Vecchio FM, Renzi C, Verzi A, Armuzzi A, Pretolani S, et al.: Prevention and treatment of low-grade B-cell primary gastric lymphoma by anti-H. pylori therapy. J Clin Gastroenterol 21: 118\u2013122, 1995","journal-title":"J Clin Gastroenterol"},{"key":"492749_CR7","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1023\/A:1026680017329","volume":"43","author":"T Zhang","year":"1998","unstructured":"Zhang T, O'Keefe SJ, Winter T, Marks IN, Ogden J: Effect of chronic duodenal ulceration and its treatment with lanzoprazole or sucralfate on gastroduodenal mucosal protein turnover and TGF-alpha, bFGF, and EGF receptor expression in humans. Dig Dis Sci 43: 2764\u20132770, 1998","journal-title":"Dig Dis Sci"},{"key":"492749_CR8","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1046\/j.1365-2036.2000.00783.x","volume":"14","author":"WK Leung","year":"2000","unstructured":"Leung WK, To KF, Chan FK, Lee TL, Chung SC, Sung JJ: Interaction of Helicobacter pylori eradication and non-steroidal anti-inflammatory drugs on gastric epithelial apoptosis and proliferation: implications on ulcerogenesis. Aliment Pharmacol Ther 14: 879\u2013885, 2000","journal-title":"Aliment Pharmacol Ther"},{"key":"492749_CR9","first-page":"1641","volume":"20","author":"A Honig","year":"2000","unstructured":"Honig A, Witte F, Mirecka J, Binder C, Schauer A: Helicobacter pylori-induced hyperproliferation: relevance for gastric cancer development in connection with mutagenic factors. Anticancer Res 20: 1641\u20131648, 2000","journal-title":"Anticancer Res"},{"key":"492749_CR10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/gut.36.3.346","volume":"36","author":"DA Lynch","year":"1995","unstructured":"Lynch DA, Mapstone NP, Clarke AM, Sobala GM, Jackson P, Morrison L, Dixon MF, Quirke P, Axon AT: Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. Gut 36: 346\u2013350, 1995","journal-title":"Gut"},{"key":"492749_CR11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1136\/jcp.52.5.367","volume":"52","author":"DA Lynch","year":"1999","unstructured":"Lynch DA, Mapstone NP, Clarke AM, Jackson P, Moayyedi P, Dixon MF, Quirke P, Axon AT: Correlation between epithelial cell proliferation and histological grading in gastric mucosa.J Clin Pathol 52: 367\u2013371, 1999","journal-title":"J Clin Pathol"},{"key":"492749_CR12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1023\/A:1026681829083","volume":"44","author":"AV Safatle-Ribeiro","year":"1999","unstructured":"Safatle-Ribeiro AV, Ribeiro U, Jr., Clarke MR, Sakai P, Ishioka S, Garrido AB, Jr., Gama-Rodrigues J, Safatle NF, Reynolds JC: Relationship between persistence of Helicobacter pylori and dysplasia, intestinal metaplasia, atrophy, inflammation, and cell proliferation following partial gastrectomy. Dig Dis Sci 44: 243\u2013252, 1999","journal-title":"Dig Dis Sci"},{"key":"492749_CR13","first-page":"1870","volume":"88","author":"F Brenes","year":"1993","unstructured":"Brenes F, Ruiz B, Correa P, Hunter F, Rhamakrishnan T, Fontham E, Shi TY: Helicobacter pylori causes hyperproliferation of the gastric epithelium: pre-and post-eradication indices of proliferating cell nuclear antigen. Am J Gastroenterol 88: 1870\u20131875, 1993","journal-title":"Am J Gastroenterol"},{"issue":"Suppl1","key":"492749_CR14","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1097\/00004836-199800001-00004","volume":"27","author":"AS Tarnawski","year":"1998","unstructured":"Tarnawski AS, Jones MK: The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: involvement of EGF-R signal transduction path-ways.J Clin Gastroenterol 27(Suppl 1): S12\u2013S20, 1998","journal-title":"J Clin Gastroenterol"},{"key":"492749_CR15","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1046\/j.1365-2036.2001.01051.x","volume":"15","author":"BC Wong","year":"2001","unstructured":"Wong BC, Wang WP, So WH, Shin VY, Wong WM, Fung FM, Liu ES, Hiu WM, Lam SK, Cho CH: Epidermal growth factor and its receptor in chronic active gastritis and gastroduodenal ulcer before and after Helicobacter pylori eradication. Aliment Pharmacol Ther 15: 1459\u20131465, 2001","journal-title":"Aliment Pharmacol Ther"},{"key":"492749_CR16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/gut.40.4.463","volume":"40","author":"PC Konturek","year":"1997","unstructured":"Konturek PC, Ernst H, Konturek SJ, Bobrzynski AJ, Faller G, Klingler C, Hahn EG: Mucosal expression and luminal release of epidermal and transforming growth factors in patients with duodenal ulcer before and after eradication of Helicobacter pylori. Gut 40: 463\u2013469, 1997","journal-title":"Gut"},{"key":"492749_CR17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/00365529850166860","volume":"33","author":"PC Konturek","year":"1998","unstructured":"Konturek PC, Bobrzynski A, Konturek SJ, Bielanski W, Faller G, Kirchner T, Hahn EG: Epidermal growth factor and transforming growth factor alpha in duodenal ulcer and non-ulcer dyspepsia patients before and after Helicobacter pylori eradication. Scand J Gastroenterol 33: 143\u2013151, 1998","journal-title":"Scand J Gastroenterol"},{"key":"492749_CR18","first-page":"CR53","volume":"8","author":"U Schiemann","year":"2002","unstructured":"Schiemann U, Konturek J, Assert R, Rembiasz K, Domschke W, Konturek S, Pfeiffer A: mRNA expression of EGF receptor ligands in atrophic gastritis before and after Helicobacter pylori eradication. Med Sci Monit 8: CR53\u2013CR58, 2002","journal-title":"Med Sci Monit"},{"key":"492749_CR19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/00365520150218020","volume":"36","author":"U Schiemann","year":"2001","unstructured":"Schiemann U, Konturek JW, Osterhoff M, Assert R, Rembiasz K, Pfeiffer D, Schatz H, Domschke W, Pfeiffer A: Decreased expression of epidermal growth factor receptor and mRNA of its ligands in Helicobacter pylori-infected gastric mucosa. Scand J Gastroenterol 36: 23\u201331, 2001","journal-title":"Scand J Gastroenterol"},{"key":"492749_CR20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mrd.1080270104","volume":"27","author":"R Derynck","year":"1990","unstructured":"Derynck R: Transforming growth factor-alpha. Mol Reprod Dev 27: 3\u20139, 1990","journal-title":"Mol Reprod Dev"},{"key":"492749_CR21","doi-asserted-by":"crossref","first-page":"19700","DOI":"10.1016\/S0021-9258(19)47169-X","volume":"264","author":"AF Cutry","year":"1989","unstructured":"Cutry AF, Kinniburgh AJ, Krabak MJ, Hui SW, Wenner CE: Induction of c-fos and c-myc proto-oncogene expression by epidermal growth factor and transforming growth factor alpha is calcium-independent. J Biol Chem 264: 19700\u201351970, 1989","journal-title":"J Biol Chem"},{"key":"492749_CR22","first-page":"1092","volume":"7","author":"PC Konturek","year":"2001","unstructured":"Konturek PC, Konturek SJ, Pierzchalski P, Bielanski W, Duda A, Marlicz K, Starzynska T, Hahn EG: Cancerogenesis in Helicobacter pylori infected stomach\u2014Role of growth factors, apoptosis and cyclooxygenases. Med Sci Monit 7: 1092\u2013107, 2001","journal-title":"Med Sci Monit"},{"key":"492749_CR23","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/BF02063256","volume":"40","author":"SJ O'Keefe","year":"1995","unstructured":"O'Keefe SJ: Measurement of gastric and duodenal mucosal protein turnover in humans. Dig Dis Sci 40: 2465\u20132468, 1995","journal-title":"Dig Dis Sci"},{"key":"492749_CR24","first-page":"E541","volume":"274","author":"C Bouteloup-Demange","year":"1998","unstructured":"Bouteloup-Demange C, Boirie Y, Dechelotte P, Gachon P, Beaufrere B: Gut mucosal protein synthesis in fed and fasted humans. Am J Physiol 274: E541\u2013E546, 1998","journal-title":"Am J Physiol"},{"key":"492749_CR25","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1073\/pnas.88.13.5892","volume":"88","author":"PW Watt","year":"1991","unstructured":"Watt PW, Lindsay Y, Scrimgeour CM, Chien PA, Gibson JN, Taylor DJ, Rennie MJ: Isolation of aminoacyl-tRNA and its labeling with stable-isotope tracers: Use in studies of human tissue protein synthesis. Proc Natl Acad Sci USA 88: 5892\u20135896, 1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"492749_CR26","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/0026-0495(82)90160-3","volume":"31","author":"DE Matthews","year":"1982","unstructured":"Matthews DE, Schwarz HP, Yang RD, Motil KJ, Young VR, Bier DM: Relationship of plasma leucine and alpha-ketoisocaproate during a L\u2013[1\u201313 C]leucine infusion in man: a method for measuring human intracellular leucine tracer enrichment. Metabolism 31: 1105\u20131112, 1982","journal-title":"Metabolism"},{"key":"492749_CR27","first-page":"E298","volume":"266","author":"MJ Rennie","year":"1994","unstructured":"Rennie MJ, Smith K, Watt PW: Measurement of human tissue protein synthesis: an optimal approach. Am J Physiol 266: E298\u2013E307, 1994","journal-title":"Am J Physiol"},{"key":"492749_CR28","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0026-0495(93)90234-F","volume":"42","author":"WM Bennet","year":"1993","unstructured":"Bennet WM, O'Keefe SJ, Haymond MW: Comparison of precursor pools with leucine, alpha-ketoisocaproate, and phenylalanine tracers used to measure splanchnic protein synthesis in man. Metabolism 42: 691\u2013695, 1993","journal-title":"Metabolism"},{"key":"492749_CR29","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/0026-0495(95)90001-2","volume":"44","author":"F Carbonnel","year":"1995","unstructured":"Carbonnel F, Messing B, Darmaun D, Rimbert A, Rongier M, Rigal O, Koziet J, Thuillier F, Desjeux JF: Energy and protein metabolism in malnutrition due to nonneoplastic gastrointestinal diseases. Metabolism 44: 1110\u20131115, 1995","journal-title":"Metabolism"},{"key":"492749_CR30","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/0148607198022005253","volume":"22","author":"SJ O'Keefe","year":"1998","unstructured":"O'Keefe SJ, Lemmer ER, Ogden JM, Winter T: The influence of intravenous infusions of glucose and amino acids on pancreatic enzyme and mucosal protein synthesis in human subjects. J Parent Enteral Nutr 22: 253\u2013258, 1998","journal-title":"J Parent Enteral Nutr"},{"key":"492749_CR31","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1440-1746.1991.tb01467.x","volume":"6","author":"JJ Misiewicz","year":"1991","unstructured":"Misiewicz JJ: The Sydney System: a new classification of gastritis. Introduction. J Gastroenterol Hepatol 6: 207\u2013208, 1991","journal-title":"J Gastroenterol Hepatol"},{"issue":"Suppl","key":"492749_CR32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/00365529209093227","volume":"191","author":"JA Louw","year":"1992","unstructured":"Louw JA, Zak J, Lucke W, Le Roux E, Jaskiewicz K, Winter T, Lastovica A, Marks IN: Triple therapy with sucralfate is as effective as triple therapy containing bismuth in eradicating Helicobacter pylori and reducing duodenal ulcer relapse rates. Scand J Gastroenterol Suppl 191: 28\u201331, 1992","journal-title":"Scand J Gastroenterol"},{"issue":"Suppl9","key":"492749_CR33","first-page":"63","volume":"31","author":"A Terano","year":"1996","unstructured":"Terano A, Shimada T, Hiraishi H: Sucralfate and Helicobacter pylori. J Gastroenterol 31(Suppl 9): 63\u201365, 1996","journal-title":"J Gastroenterol"},{"issue":"Suppl","key":"492749_CR34","first-page":"9","volume":"210","author":"A Tarnawski","year":"1995","unstructured":"Tarnawski A, Tanoue K, Santos AM, Sarfeh IJ: Cellular and molecular mechanisms of gastric ulcer healing. Is the quality of mucosal scar affected by treatment? Scand J Gastroenterol Suppl 210: 9\u201314, 1995","journal-title":"Scand J Gastroenterol"},{"issue":"Suppl","key":"492749_CR35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/00365529509107754","volume":"208","author":"S Szabo","year":"1995","unstructured":"Szabo S, Kusstatscher S, Sandor Z, Sakoulas G: Molecular and cellular basis of ulcer healing. Scand J Gastroenterol Suppl 208: 3\u20138, 1995","journal-title":"Scand J Gastroenterol"},{"key":"492749_CR36","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1136\/gut.39.6.807","volume":"39","author":"SE Patchett","year":"1996","unstructured":"Patchett SE, Katelaris PH, Zhang ZW, Alstead EM, Domizio P, Farthing MJ: Ornithine decarboxylase activity is a marker of premalignancy in longstanding Helicobacter pylori infection. Gut 39: 807\u2013810, 1996","journal-title":"Gut"},{"key":"492749_CR37","first-page":"7415","volume":"50","author":"S Preston-Martin","year":"1990","unstructured":"Preston-Martin S, Pike MC, Ross RK, Jones PA, Henderson BE: Increased cell division as a cause of human cancer. Cancer Res 50: 7415\u20137421, 1990","journal-title":"Cancer Res"},{"key":"492749_CR38","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1136\/gut.38.4.498","volume":"38","author":"SF Moss","year":"1996","unstructured":"Moss SF, Calam J, Agarwal B, Wang S, Holt PR: Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut 38: 498\u2013501, 1996","journal-title":"Gut"},{"key":"492749_CR39","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/S0016-5085(97)70003-9","volume":"113","author":"S Wagner","year":"1997","unstructured":"Wagner S, Beil W, Westermann J, Logan RP, Bock CT, Trautwein C, Bleck JS, Manns MP: Regulation of gastric epithelial cell growth by Helicobacter pylori: Evidence for a major role of apoptosis. Gastroenterology 113: 1836\u20131847, 1997","journal-title":"Gastroenterology"},{"key":"492749_CR40","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/gut.45.1.24","volume":"45","author":"J Shibata","year":"1999","unstructured":"Shibata J, Goto H, Arisawa T, Niwa Y, Hayakawa T, Nakayama A, Mori N: Regulation of tumour necrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection. Gut 45: 24\u201331, 1999","journal-title":"Gut"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/B:DDAS.0000034550.08623.9b.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/B:DDAS.0000034550.08623.9b\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/B:DDAS.0000034550.08623.9b.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T03:36:24Z","timestamp":1753760184000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/B:DDAS.0000034550.08623.9b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["492749"],"URL":"https:\/\/doi.org\/10.1023\/b:ddas.0000034550.08623.9b","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}