{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:08:00Z","timestamp":1790935680949,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1023\/b:ddas.0000042242.22898.d9","type":"journal-article","created":{"date-parts":[[2004,9,21]],"date-time":"2004-09-21T21:05:15Z","timestamp":1095800715000},"page":"1433-1437","source":"Crossref","is-referenced-by-count":103,"title":["Decreased Total and Corrected Antioxidant Capacity in Patients with Inflammatory Bowel Disease"],"prefix":"10.1007","volume":"49","author":[{"given":"Ioannis E.","family":"Koutroubakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki","family":"Malliaraki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippos D.","family":"Dimoulios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Karmiris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Castanas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias A.","family":"Kouroumalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"issue":"344","key":"495603_CR1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/S0140-6736(94)92831-2","volume":"24","author":"MB Grisham","year":"1994","unstructured":"Grisham MB: Oxidants and free radicals in inflammatory bowel disease. Lancet 24(344):859\u2013861, 1994","journal-title":"Lancet"},{"key":"495603_CR2","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1046\/j.1365-2036.2002.01378.x","volume":"16","author":"L Kruidenier","year":"2002","unstructured":"Kruidenier L, Verspaget HW: Review article: Oxidative stress as a pathogenic factor in inflammatory bowel disease-Radicals or ridiculous? Aliment Pharmacol Ther 16:1997\u20132015, 2002","journal-title":"Aliment Pharmacol Ther"},{"key":"495603_CR3","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/BF01535990","volume":"33","author":"T Kitahora","year":"1988","unstructured":"Kitahora T, Suzuki K, Asakura H, Yoshida T, Suematsu M, Watanabe M, Aiso S, Tsuchiya M: Active oxygen species generated by monocytes and polymorphonuclear cells in Crohn's disease. Dig Dis Sci 33:951\u2013955, 1988","journal-title":"Dig Dis Sci"},{"key":"495603_CR4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0016-5085(92)91111-G","volume":"103","author":"A Keshavarzian","year":"1992","unstructured":"Keshavarzian A, Sedghi S, Kanofsky J, List T, Robinson C, Ibrahim C, Winship D: Excessive production of reactive oxygen metabolites by inflamed colon: Analysis by chemiluminescence probe. Gastroenterology 103:177\u2013185, 1992","journal-title":"Gastroenterology"},{"key":"495603_CR5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1080\/003655201317097146","volume":"36","author":"A D'Odorico","year":"2001","unstructured":"D'Odorico A, Bortolan S, Cardin R, D'Inca' R, Martines D, Ferronato A, Sturniolo GC: Reduced plasma antioxidant concentrations and increased oxidative DNA damage in inflammatory bowel disease. Scand J Gastroenterol 36:1289\u20131294, 2001","journal-title":"Scand J Gastroenterol"},{"key":"495603_CR6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/path.1409","volume":"201","author":"L Kruidenier","year":"2003","unstructured":"Kruidenier L, Kuiper I, Lamers CB, Verspaget HW: Intestinal ox-idative damage in inflammatory bowel disease: Semi-quantification, localization, and association with mucosal antioxidants. J Pathol 201:28\u201336, 2003","journal-title":"J Pathol"},{"key":"495603_CR7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/sj.ejcn.1600764","volume":"53","author":"D Genser","year":"1999","unstructured":"Genser D, Kang MH, Vogelsang H, Elmadfa I: Status of lipidsoluble antioxidants and TRAP in patients with Crohn's disease and healthy controls. Eur J Clin Nutr 53:675\u2013679, 1999","journal-title":"Eur J Clin Nutr"},{"key":"495603_CR8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/path.1408","volume":"201","author":"L Kruidenier","year":"2003","unstructured":"Kruidenier L, Kuiper I, Van Duijn W, Mieremet-Ooms MA, van Hogezand RA, Lamers CB, Verspaget HW: Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease. J Pathol 201:17\u201327, 2003","journal-title":"J Pathol"},{"key":"495603_CR9","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/0891-5849(95)94362-H","volume":"19","author":"GD Buffinton","year":"1995","unstructured":"Buffinton GD, Doe WF: Depleted mucosal antioxidant defences in inflammatory bowel disease. Free Rad Biol Med 19:911\u2013918, 1995","journal-title":"Free Rad Biol Med"},{"key":"495603_CR10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF01974941","volume":"21","author":"I Ahnfelt-Ronne","year":"1987","unstructured":"Ahnfelt-Ronne I, Nielssen OH: The anti-inflammatory moiety of sulfasalzine, 5-aminosalicylic acid, is a radical scavanger. Agents Actions 21:191\u2013194, 1987","journal-title":"Agents Actions"},{"key":"495603_CR11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0899-9007(03)00162-X","volume":"19","author":"DS Barbosa","year":"2003","unstructured":"Barbosa DS, Cecchini R, El Kadri MZ, Rodriguez MA, Burini RC, Dichi I: Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids. Nutrition 19:837\u2013842, 2003","journal-title":"Nutrition"},{"key":"495603_CR12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jca.10054","volume":"18","author":"A Hirayama","year":"2003","unstructured":"Hirayama A, Nagase S, Ueda A, Ishizu T, Taru Y, Yoh K, Hirayama K, Kobayashi M, Koyama A: Oxidative stress during leukocyte absorption apheresis. J Clin Apheresis 18:61\u201366, 2003","journal-title":"J Clin Apheresis"},{"key":"495603_CR13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1472-6890-2-3","volume":"2","author":"M Kampa","year":"2002","unstructured":"Kampa M, Nistikaki A, Tsaoussis V, Maliaraki N, Notas G, Castanas E: A new automated method for the determination of the total antioxidant capacity (TAC) of human plasma, based on the crocin bleaching assay. BMC Clin Pathol 2:3, 2002","journal-title":"BMC Clin Pathol"},{"key":"495603_CR14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3109\/00365528909091339","volume":"24","author":"JE Lennard-Jones","year":"1989","unstructured":"Lennard-Jones JE: Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 24:2\u20136, 1989","journal-title":"Scand J Gastroenterol Suppl"},{"key":"495603_CR15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0016-5085(76)80163-1","volume":"70","author":"WR Best","year":"1976","unstructured":"Best WR, Becktel JM, Singleton JW, Kern F Jr: Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology 70:439\u2013444, 1976","journal-title":"Gastroenterology"},{"key":"495603_CR16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/gut.43.1.29","volume":"43","author":"RS Walmsley","year":"1998","unstructured":"Walmsley RS, Ayres RC, Pounder RE, Allan RN: A simple clinical colitis activity index. Gut 43:29\u201332, 1998","journal-title":"Gut"},{"key":"495603_CR17","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000018171","volume":"198","author":"E Severin","year":"1999","unstructured":"Severin E, Nave B, Stander M, Ott R, Traupe H: Total antioxidative capacity is normal in sera from psoriasis patients despite elevated bilirubin, tocopherol and urate levels. Dermatology198:336\u2013339, 1999","journal-title":"Dermatology"},{"key":"495603_CR18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2369-4-4","volume":"4","author":"N Malliaraki","year":"2003","unstructured":"Malliaraki N, Mpliamplias D, Kampa M, Perakis K, Margioris AN, Castanas E: Total and corrected antioxidant capacity in hemodia-lyzed patients. BMC Nephrology 4:4, 2003","journal-title":"BMC Nephrology"},{"key":"495603_CR19","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0009-9120(02)00361-2","volume":"35","author":"A Tuzun","year":"2002","unstructured":"Tuzun A, Erdil A, Inal V, Aydin A, Bagci S, Yesilova Z, Sayal A, Karaeren N, Dagalp K: Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease. Clin Biochem 35:569\u2013572, 2002","journal-title":"Clin Biochem"},{"key":"495603_CR20","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1136\/gut.32.10.1146","volume":"32","author":"TP Mulder","year":"1991","unstructured":"Mulder TP, Verspaget HW, Janssens AR, DeBruin PAF, Pena AS, Lamers CBHW: Decrease in two intestinal Cu\/Zn containing proteins with antioxidant function in inflammatory bowel disease. Gut 32:1146\u20131150, 1991","journal-title":"Gut"},{"key":"495603_CR21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00054725-199712000-00003","volume":"3","author":"U Dagli","year":"1997","unstructured":"Dagli U, Balk M, Yucel D, Ulker A, Over H, Saydam G, Sahin B: The role of reactive oxygen metabolites in ulcerative colitis. Inflamm Bowel Dis 3:260\u2013264, 1997","journal-title":"Inflamm Bowel Dis"},{"key":"495603_CR22","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1007\/BF02093613","volume":"41","author":"L Lih-Brody","year":"1996","unstructured":"Lih-Brody L, Powell SR, Collier KP, Reddy GM, Cerchia R, Kahn E, Weissman GS, Katz S, Floyd RA, McKinley MJ, Fisher SE, Mullin GE: Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Dig Dis Sci 41:2078\u20132086, 1996","journal-title":"Dig Dis Sci"},{"key":"495603_CR23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1440-1746.1995.tb01068.x","volume":"10","author":"L Bhaskar","year":"1995","unstructured":"Bhaskar L, Ramakrishna BS, Balasubramanian KA: Colonic mucosal antioxidant enzymes and lipid peroxide levels in normal subjects and patients with ulcerative colitis. J Gastroent Hepatol 10:140\u2013143, 1995","journal-title":"J Gastroent Hepatol"},{"key":"495603_CR24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/bmmb.1994.1062","volume":"53","author":"T Iantomasi","year":"1994","unstructured":"Iantomasi T, Marraccini P, Favilla F, Vincenzini MT, Ferretti P, Tonelli F: Glutathione metabolism in Crohn's disease. Biochem Med Metab Biol 53:87\u201391, 1994","journal-title":"Biochem Med Metab Biol"},{"key":"495603_CR25","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1080\/00365529850171936","volume":"33","author":"GC Sturniolo","year":"1998","unstructured":"Sturniolo GC, Mestriner C, Lecis PE, D'Odorico A, Venturi C, Irato P, Cecchetto A, Tropea A, Longo G, D'Inca R: Altered plasma and mucosal concentrations of trace elements and antioxidants in active ulcerative colitis. Scand J Gastroenterol 33:644\u2013649, 1998","journal-title":"Scand J Gastroenterol"},{"key":"495603_CR26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/10715769509147535","volume":"22","author":"GD Buffinton","year":"1995","unstructured":"Buffinton GD, Doe WF: Altered ascorbic acid status in the mucosa from inflammatory bowel disease patients. Free Radic Res 22:131\u2013143, 1995","journal-title":"Free Radic Res"},{"key":"495603_CR27","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1023\/A:1005517824877","volume":"45","author":"TR Koch","year":"2000","unstructured":"Koch TR, Yuan LX, Stryker SJ, Ratliff P, Telford GL, Opara EC: Total antioxidant capacity of colon in patients with chronic ulcerative colitis. Dig Dis Sci 45:1814\u20131819, 2000","journal-title":"Dig Dis Sci"},{"key":"495603_CR28","first-page":"1015","volume":"47","author":"I Durak","year":"2000","unstructured":"Durak I, Yasa MH, Bektas A, Kacmaz M, Cimen MY, Ozturk HS: Mucosal antioxidant defense is not impaired in ulcerative colitis. Hepatogastroenterology 47:1015\u20131017, 2000","journal-title":"Hepatogastroenterology"},{"key":"495603_CR29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/00054725-200401000-00003","volume":"10","author":"R D'Inca","year":"2004","unstructured":"D'Inca R, Cardin R, Benazzato L, Angriman I, Martines D, Sturniolo GC: Oxidative DNA damage in the mucosa of ulcerative colitis increases with disease duration and displasia. Infamm Bowel Dis 10:23\u201327, 2004","journal-title":"Infamm Bowel Dis"},{"key":"495603_CR30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/carcin\/24.3.353","volume":"24","author":"DN Seril","year":"2003","unstructured":"Seril DN, Liao J, Yang GY, Yang CS: Oxidative stress and ulcerative colitis-associated carcinogenesis: Studies in humans and animal models. Carcinogenesis 24:353\u2013362, 2003","journal-title":"Carcinogenesis"},{"key":"495603_CR31","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0891-5849(00)00394-4","volume":"29","author":"A Ghiselli","year":"2000","unstructured":"Ghiselli A, Serafini M, Natella F, Scaccini C: Total antioxidant capacity as a tool to assess redox status: Critical viewand experimental data. Free Radic Biol Med 29:1106\u20131114, 2000","journal-title":"Free Radic Biol Med"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/B:DDAS.0000042242.22898.d9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/B:DDAS.0000042242.22898.d9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/B:DDAS.0000042242.22898.d9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T03:55:58Z","timestamp":1753761358000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/B:DDAS.0000042242.22898.d9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["495603"],"URL":"https:\/\/doi.org\/10.1023\/b:ddas.0000042242.22898.d9","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}