{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:18:59Z","timestamp":1770016739198,"version":"3.49.0"},"reference-count":19,"publisher":"Hogrefe Publishing Group","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zeitschrift f\u00fcr Kinder- und Jugendpsychiatrie und Psychotherapie"],"published-print":{"date-parts":[[2000,5]]},"abstract":"<jats:p> Zusammenfassung: Als eine m\u00f6gliche Nebenwirkung selektiver Serotonin-Wiederaufnahmehemmer wird die Exazerbation einer mit Tiaprid behandelten Ticst\u00f6rung bei einem 12-j\u00e4hrigen Jungen unter Verordnung von Paroxetin wegen eines depressiven Syndroms beschrieben. Als urs\u00e4chliche Faktoren sind hierbei zu diskutieren eine cholinerge Restaktivit\u00e4t von Paroxetin, die beobachtbare Antriebssteigerung unter Paroxetin, metabolische Eigenschaften sowie die Proteinbindung. 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