{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T11:14:10Z","timestamp":1652008450174},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p> Eine 67-j\u00e4hrige Patientin erlitt einen Herzinfarkt. In der Koronarangiographie fand sich thrombotisches Material in Koronararterien. Ursache daf\u00fcr war eine paroxysmale n\u00e4chtliche H\u00e4moglobinurie, ein Stammzelldefekt, welcher durch komplementvermittelte h\u00e4molytische Sch\u00fcbe mit thromboembolischen Ereignissen gekennzeichnet ist. Wegen der koronaren Thrombosen wurden eine Antikoagulation und eine Antiaggregation eingeleitet. Darunter kam es zu einer intrazerebralen Massenblutung, an der die Patientin trotz zweimaliger neurochirurgischer Kraniektomie schlie\u00dflich verstarb. Dieser tragische Fall zeigt, dass eine antithrombotische Behandlung immer wieder eine Gratwanderung mit ungewissem Ausgang ist. <\/jats:p>","DOI":"10.1024\/0040-5930\/a000105","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T03:32:32Z","timestamp":1290655952000},"page":"609-612","source":"Crossref","is-referenced-by-count":0,"title":["Auf dem schmalen Grat zwischen Thrombosen und Verbluten"],"prefix":"10.1024","volume":"67","author":[{"given":"Walter H.","family":"Reinhart","sequence":"first","affiliation":[{"name":"Departement Innere Medizin, Kantonsspital Graub\u00fcnden, Chur"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930\/a000105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:55:44Z","timestamp":1652007344000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930\/a000105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12,1]]}},"alternative-id":["10.1024\/0040-5930\/a000105"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930\/a000105","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}