{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T11:15:00Z","timestamp":1652008500719},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p> Die Akromegalie ist eine seltene Erkrankung mit langsam einschleichenden Krankheitsmanifestationen, was die Diagnose in der Regel um Jahre verz\u00f6gert. Typisch f\u00fcr die Akromegalie sind neben dem akralen Wachstum, vor allem die Hyperhidrose und kardiorespiratorische Erkrankungen, welche die Mortalit\u00e4t gegen\u00fcber der Normalpopulation ums Dreifache erh\u00f6hen. Die klinische Verdachtsdiagnose wird durch die Messung des hGH im Glukose-Suppression-Test und die Bestimmung des IGF-1 gesichert. Die Ursache ist praktisch immer ein Hypophysen-Makroadenom, welches meistens kombiniert chirurgisch mittels transsphenoidaler Resektion und medikament\u00f6s mit Somatostatin-Analoga, Pegvisomant und Dopamin-Agonisten behandelt wird. <\/jats:p>","DOI":"10.1024\/0040-5930\/a000108","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T03:32:32Z","timestamp":1290655952000},"page":"623-627","source":"Crossref","is-referenced-by-count":1,"title":["Der sanfte Riese..."],"prefix":"10.1024","volume":"67","author":[{"given":"Christoph","family":"Henzen","sequence":"first","affiliation":[{"name":"Abteilung Endokrinologie\/Diabetologie, Departement Medizin, Luzerner Kantonsspital, Luzern"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930\/a000108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:55:48Z","timestamp":1652007348000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930\/a000108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12,1]]}},"alternative-id":["10.1024\/0040-5930\/a000108"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930\/a000108","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}