{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:45:10Z","timestamp":1760100310508},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2011,1,1]]},"abstract":"<jats:p> Phytotherapeutika haben wie alle zur Behandlung am Menschen eingesetzten Stoffe auch unerw\u00fcnschte Wirkungen. So f\u00fchrt Johanniskraut \u00fcber die Aktivierung des nukle\u00e4ren Pregnan-X-Rezeptors zu einer vermehrten Enzymsynthese von CYP3A4, was zu einer verminderten Plasmakonzentration einer Reihe von CYP3A4-Substraten f\u00fchrt. Echinacea kann die Wirkung von Immunsupressiva vermindern. Ginseng und Ginkgo biloba sollten nicht zusammen mit gerinnungshemmenden Arzneimitteln eingesetzt werden. Baldrian kann in Kombination mit Barbituraten zu exzessiver Sedierung f\u00fchren. <\/jats:p>","DOI":"10.1024\/0040-5930\/a000120","type":"journal-article","created":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T03:32:39Z","timestamp":1293075159000},"page":"54-57","source":"Crossref","is-referenced-by-count":12,"title":["Phytopharmaka als Ursache von unerw\u00fcnschten Arzneimittelwirkungen"],"prefix":"10.1024","volume":"68","author":[{"given":"Verena","family":"Hafner-Blumenstiel","sequence":"first","affiliation":[{"name":"Abteilung Klinische Pharmakologie und Pharmakoepidemiologie, Medizinische Klinik (Krehl-Klinik), Universit\u00e4tsklinikum Heidelberg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930\/a000120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:59:55Z","timestamp":1652007595000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930\/a000120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1,1]]}},"alternative-id":["10.1024\/0040-5930\/a000120"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930\/a000120","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,1]]}}}