{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T11:41:22Z","timestamp":1652010082286},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2011,4,1]]},"abstract":"<jats:p> Die Autoimmunhepatitis (AIH) ist eine chronische, progressive Lebererkrankung, die durch das histologische Bild einer Interfacehepatitis, einer Hypergammaglobulin\u00e4mie und zirkulierende Autoantik\u00f6rper charakterisiert ist. Die AIH tritt in allen Altersgruppen auf und betrifft h\u00e4ufiger Frauen als M\u00e4nner (Verh\u00e4ltnis 3:1). Das Spektrum der AIH reicht von asymptomatischer Erkrankung \u00fcber die akute oder auch fulminate Hepatitis bis hin zum Leberversagen. Zur Remissionsinduktion werden Kortikosteroide eingesetzt; ein schnelles Therapieansprechen unterst\u00fctzt die Diagnose und f\u00fchrt zu einer guten Langzeitprognose. In der Erhaltungstherapie wird bevorzugt Azathioprin eingesetzt. Die Therapiedauer sollte mindestens zwei, besser vier 4 Jahre betragen, um das Rezidivrisiko m\u00f6glichst zu reduzieren. <\/jats:p>","DOI":"10.1024\/0040-5930\/a000149","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T02:33:02Z","timestamp":1301452382000},"page":"189-194","source":"Crossref","is-referenced-by-count":2,"title":["Autoimmunhepatitis"],"prefix":"10.1024","volume":"68","author":[{"given":"Michael Christian","family":"Sulz","sequence":"first","affiliation":[{"name":"Fachbereich Gastroenterologie\/Hepatologie, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tilman J\u00f6rn","family":"Gerlach","sequence":"additional","affiliation":[{"name":"Fachbereich Gastroenterologie\/Hepatologie, Kantonsspital St. Gallen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930\/a000149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:58:12Z","timestamp":1652007492000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930\/a000149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4,1]]}},"alternative-id":["10.1024\/0040-5930\/a000149"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930\/a000149","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,1]]}}}