{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T23:03:16Z","timestamp":1756076596098},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p> Zusammenfassung. Die Gicht ist die h\u00e4ufigste Arthritis weltweit mit zunehmender Pr\u00e4valenz in den entwickelten L\u00e4ndern und mit enormen sozio\u00f6konomischen Konsequenzen. Das Wissen \u00fcber die Pathomechanismen, welche zur Arthritis f\u00fchren und diese einschr\u00e4nken, hat in den letzten Jahren stark zugenommen. Entsprechend zeichnen sich auch neue Therapieans\u00e4tze und Therapeutika ab. In dieser \u00dcbersichtsarbeit werden neben einigen Aspekten der Klinik, Diagnose und Therapie der Gicht, detailliert die intrazellul\u00e4ren Mechanismen, welche zur NLRP3 Inflammasom Aktivierung und IL-1beta Sekretion f\u00fchren, behandelt. Sie gibt auch einen Ausblick auf ausgew\u00e4hlte, neue therapeutische Ans\u00e4tze. <\/jats:p>","DOI":"10.1024\/0040-5930\/a000771","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T13:20:16Z","timestamp":1458739216000},"page":"147-152","source":"Crossref","is-referenced-by-count":1,"title":["Ursachen, Mechanismen und m\u00f6gliche therapeutische Ziele der Gicht"],"prefix":"10.1024","volume":"73","author":[{"given":"Tobias","family":"Manigold","sequence":"first","affiliation":[{"name":"Abteilung f\u00fcr Rheumatologie, Universit\u00e4tsspital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930\/a000771","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T07:40:03Z","timestamp":1615966803000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930\/a000771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1024\/0040-5930\/a000771"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930\/a000771","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3]]}}}