{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:36:52Z","timestamp":1769150212584,"version":"3.49.0"},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:p> Zusammenfassung. Die CML war die erste maligne Krankheit, bei welcher die molekularen Erkenntnisse zur Pathogenese in die Entwicklung einer spezifischen, gegen das Onkoprotein gerichteten Therapie, f\u00fchrte. Mit der Einf\u00fchrung der Tyrosinkinase Inhibitoren (TKI) um die Jahrtausendwende wurde die Behandlung der CML revolutioniert. Die Lebenserwartung von CML Patienten im Zeitalter der TKI entspricht derjenigen der Normalbev\u00f6lkerung. Bei einem Teil der Patienten mit sehr gutem Ansprechen auf die TKI Behandlung, kann die Therapie unter entsprechenden Vorsichtsmassnahmen gestoppt werden mit dem Ziel, eine langfristige Therapiefreie Remission (TFR) zu erleben. <\/jats:p>","DOI":"10.1024\/0040-5930\/a001124","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T19:29:48Z","timestamp":1588102188000},"page":"503-509","source":"Crossref","is-referenced-by-count":9,"title":["Chronische Myeloische Leuk\u00e4mie \u2013 Update                2020"],"prefix":"10.1024","volume":"76","author":[{"given":"Dominik","family":"Heim","sequence":"first","affiliation":[{"name":"H\u00e4matologie, Universit\u00e4tsspital Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Ebn\u00f6ther","sequence":"additional","affiliation":[{"name":"Onkologie \/ H\u00e4matologie, Claraspital, Basel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genevi\u00e8ve","family":"Favre","sequence":"additional","affiliation":[{"name":"3 H\u00e4matologie, Kantonsspital Baselland, Liestal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930\/a001124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T06:31:39Z","timestamp":1615962699000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930\/a001124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1024\/0040-5930\/a001124"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930\/a001124","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12]]}}}