{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T20:44:46Z","timestamp":1649018686607},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:p> Zusammenfassung. Eine positive Familienanamnese f\u00fcr Mammakarzinom oder \/ und Ovarialkarzinom ist der Hauptrisikofaktor einer Frau, selbst an einem Mammakarzinom (oder \/ und Ovarialkarzinom) zu erkranken. Eine detaillierte Auswertung der Familienanamnese durch den Onkogenetiker erlaubt die Indikation f\u00fcr einen Gentest zu stellen. Die in der Schweiz verwendeten Kriterien zur Testung sind genau festgelegt. Hochrisiko-Frauen lassen sich durch den Nachweis einer pathogenen Mutation eines f\u00fcr Brust- und Eierstockkrebs pr\u00e4disponierenden Gens wie BRCA1 oder BRCA2 identifizieren. Die Betreuung der Mutationstr\u00e4gerinen muss gem\u00e4ss internationalen Empfehlungen erfolgen. <\/jats:p>","DOI":"10.1024\/0040-5930\/a001251","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T07:13:46Z","timestamp":1617002026000},"page":"145-148","source":"Crossref","is-referenced-by-count":0,"title":["Wer braucht eine genetische Beratung?"],"prefix":"10.1024","volume":"78","author":[{"given":"Christian","family":"Monnerat","sequence":"first","affiliation":[{"name":"Centre Coordonn\u00e9 d\u2019Oncologie, H\u00f4pital du Jura, Del\u00e9mont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u00ebl","family":"Dobbie","sequence":"additional","affiliation":[{"name":"Centre Coordonn\u00e9 d\u2019Oncologie, H\u00f4pital du Jura, Del\u00e9mont"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930\/a001251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T10:46:54Z","timestamp":1617187614000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930\/a001251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1024\/0040-5930\/a001251"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930\/a001251","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}