{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T21:15:37Z","timestamp":1650575737176},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:p> Zusammenfassung. Die neurodegenerative Erkrankung Achalasie (veraltet: \u00abKardiaspasmus\u00bb) stellt nach der Refluxerkrankung die zweith\u00e4ufigste funktionelle Erkrankung des \u00d6sophagus dar. Sie ist mit einem extrem hohen Leidensdruck f\u00fcr die Patienten verbunden. Pathophysiologisch handelt es sich um eine Kombination aus fehlender schluckreflektorischer Relaxation am Mageneingang und gest\u00f6rter Peristaltik der tubul\u00e4ren Speiser\u00f6hre. Goldstandard in der Diagnostik ist die hochaufl\u00f6sende Manometrie. Die Erkrankung ist nicht heilbar, das therapeutisch Spektrum umfasst medikament\u00f6se, endoskopisch-interventionelle und operative Verfahren. <\/jats:p>","DOI":"10.1024\/0040-5930\/a001339","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T07:13:35Z","timestamp":1650438815000},"page":"133-140","source":"Crossref","is-referenced-by-count":0,"title":["Update Achalasie"],"prefix":"10.1024","volume":"79","author":[{"given":"Ulrich Klaus","family":"Fetzner","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Allgemeinchirurgie, Viszeral-, Thorax-, Kinder- und Endokrine                Chirurgie, Johannes Wesling Klinikum, Universit\u00e4tsklinikum der Ruhr Universit\u00e4t                Bochum, Minden, Deutschland"},{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie,                Universit\u00e4tsmedizin der Johannes-Gutenberg-Universit\u00e4t Mainz, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Trujillo","sequence":"additional","affiliation":[{"name":"Chirurgische Klinik, Kantonsspital Frauenfeld, Schweiz"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Dimopoulos","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemeinchirurgie, Viszeral-, Thorax-, Kinder- und Endokrine                Chirurgie, Johannes Wesling Klinikum, Universit\u00e4tsklinikum der Ruhr Universit\u00e4t                Bochum, Minden, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Frederic","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Kinderchirurgie, Universit\u00e4tsklinikum                D\u00fcsseldorf, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Berlth","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie,                Universit\u00e4tsmedizin der Johannes-Gutenberg-Universit\u00e4t Mainz, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Mann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie,                Universit\u00e4tsmedizin der Johannes-Gutenberg-Universit\u00e4t Mainz, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Grimminger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplantationschirurgie,                Universit\u00e4tsmedizin der Johannes-Gutenberg-Universit\u00e4t Mainz, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berthold","family":"Gerdes","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemeinchirurgie, Viszeral-, Thorax-, Kinder- und Endokrine                Chirurgie, Johannes Wesling Klinikum, Universit\u00e4tsklinikum der Ruhr Universit\u00e4t                Bochum, Minden, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930\/a001339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T07:13:35Z","timestamp":1650438815000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930\/a001339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1024\/0040-5930\/a001339"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930\/a001339","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}