{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:18:31Z","timestamp":1694625511217},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[1999,11,1]]},"abstract":"<jats:p> Das Interesse an den Prionkrankheiten und speziell an der h\u00e4ufigsten menschlichen Form, der Creutzfeldt-Jakob Krankheit (CJD), ist zur Zeit aus zwei Gr\u00fcnden gro\u00df: 1) Die Bev\u00f6lkerung m\u00f6chte begreiflicherweise wissen, ob der Konsum von Rindfleisch eine CJD verursachen kann. Diese M\u00f6glichkeit r\u00fcckt in den Wahrscheinlichkeitsbereich durch die Entdeckung einer \u00abneuen Variante\u00bb der CJD in England (nvCJD), welche wahrscheinlich durch den gleichen Prionenstamm verursacht wird wie die bovine spongiforme Enzephalopathie (BSE = \u00abRinderwahnsinn\u00bb). 2) Infektiologen und Neurowissenschaftler erkennen in den Prionkrankheiten das Modell eines grunds\u00e4tzlich neuen infekti\u00f6sen Prinzips, indem die gleiche Krankheit sowohl erblich auftreten wie auch \u00fcbertragen werden kann. Schlie\u00dflich ist dieser neue pathogene Mechanismus f\u00fcr die Erforschung m\u00f6glicher Ursachen degenerativer Hirnerkrankungen von Interesse. <\/jats:p>","DOI":"10.1024\/0040-5930.56.11.675","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:20:14Z","timestamp":1138710014000},"page":"675-679","source":"Crossref","is-referenced-by-count":1,"title":["Human prion diseases"],"prefix":"10.1024","volume":"56","author":[{"family":"Sturzenegger","sequence":"first","affiliation":[{"name":"Neurologische Universit\u00e4tsklinik, Inselspital, Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930.56.11.675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:43:29Z","timestamp":1652006609000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930.56.11.675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1999,11,1]]}},"alternative-id":["10.1024\/0040-5930.56.11.675"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930.56.11.675","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11,1]]}}}