{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T14:02:23Z","timestamp":1720620143244},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[1999,9,1]]},"abstract":"<jats:p> Der Fall eines 76j\u00e4hrigen Mannes mit Entgleisung der oralen Antikoagulation (unme\u00dfbar hoher INR-Wert) wird vorgestellt und die m\u00f6glichen Ursachen werden diskutiert. Wahrscheinlich war eine Cholestase mit verminderter Vitamin K-Resorption urs\u00e4chlich beteiligt, wie das schlechte Ansprechen auf perorale Vitamin K-Gabe und die Korrektur des INR-Werts auf intraven\u00f6ses Vitamin K1 nahelegen. Der Quick-Test (Synonyme: Thromboplastinzeit, \u00abProthrombin time\u00bb) erfa\u00dft das sogenannte extrinsische System und den gemeinsamen Weg der Gerinnung. Ein verminderter Quickprozentwert ist vieldeutig und mu\u00df bei Unklarheit durch Analyse der Einzelfaktoren abgekl\u00e4rt werden: Pr\u00e4analytische Fehler, Plasmaverd\u00fcnnung bei gerinnungsfaktorenfreiem Volumenersatz, Verminderung der Vitamin K-abh\u00e4ngigen Faktoren (orale Antikoagulation, Vitamin K-Mangel), Lebersynthese-St\u00f6rungen, disseminierte intravasale Gerinnung, isolierter Mangel von Faktor II, V, VII, X oder Fibrinogen, massive Heparin-Kontamination, sowie als physiologischer Befund beim Neugeborenen. <\/jats:p>","DOI":"10.1024\/0040-5930.56.9.477","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:20:10Z","timestamp":1138710010000},"page":"477-480","source":"Crossref","is-referenced-by-count":1,"title":["Case 1: Very high INR values poorly responding to oral vitamin K in a patient under long-term oral anticoagulant treatment: Cholestasis as the possible cause"],"prefix":"10.1024","volume":"56","author":[{"family":"Fontana","sequence":"first","affiliation":[{"name":"H\u00e4matologisches Zentrallabor der Universit\u00e4t, Inselspital, Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Zeerleder","sequence":"additional","affiliation":[{"name":"H\u00e4matologisches Zentrallabor der Universit\u00e4t, Inselspital, Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"L\u00e4mmle","sequence":"additional","affiliation":[{"name":"H\u00e4matologisches Zentrallabor der Universit\u00e4t, Inselspital, Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930.56.9.477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:44:20Z","timestamp":1652006660000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930.56.9.477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1999,9,1]]}},"alternative-id":["10.1024\/0040-5930.56.9.477"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930.56.9.477","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,9,1]]}}}