{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:20:30Z","timestamp":1694625630561},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2000,6,1]]},"abstract":"<jats:p> Die Blockade der Carboanhydrase oder in differenzierter Weise die Hemmung einzelner Isoenzyme f\u00fchrt zu einer signifikanten metabolischen Azidose durch renalen Bicarbonatverlust. Der dadurch entstehende Anstieg des arteriellen pCO<jats:sub>2<\/jats:sub> verursacht \u00fcber zentrale und periphere Chemorezeptoren eine Atemstimulation. Diese kann als Prophylaxe der H\u00f6henkrankheit, in begrenztem Ma\u00dfe therapeutisch beim Schlaf-Apnoe-Syndrom, und bei entsprechender Indikation therapeutisch bei chronisch obstruktiven Lungenerkrankungen ausgen\u00fctzt werden. Obwohl bescheiden in der Wirkung scheint dieser therapeutische Weg bei der Behandlung von einigen Patienten offen. Die Indikation muss aber ensprechend eng gesteckt werden. <\/jats:p>","DOI":"10.1024\/0040-5930.57.6.351","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:20:55Z","timestamp":1138710055000},"page":"351-354","source":"Crossref","is-referenced-by-count":1,"title":["Inhibition of renal carbonic anhydrase for stimulation of ventilation \u2013 an obsolete indication?"],"prefix":"10.1024","volume":"57","author":[{"family":"Sch\u00f6ni","sequence":"first","affiliation":[{"name":"Universit\u00e4ts-Kinderklinik, Inselspital Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930.57.6.351","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:49:59Z","timestamp":1652006999000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930.57.6.351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,6,1]]}},"alternative-id":["10.1024\/0040-5930.57.6.351"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930.57.6.351","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6,1]]}}}