{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T01:59:53Z","timestamp":1700272793324},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2001,12,1]]},"abstract":"<jats:p> Die Resektion einzelner Metastasen hat sich in der chirurgischen Onkologie breit eingeb\u00fcrgert. Beispiele sind die chirurgische Entfernung von Lebermetastasen beim kolo-rektalen Karzinom, die Resektion von Sarkommetastasen in der Lunge, und die operative Entfernung solit\u00e4rer Hirnmetastasen. Nur die letzt genannte Indikation ist durch die Resultate randomisierter Studien belegt. Zu den anderen Themen liegen zahlreiche Phase II Studien und Fallserien vor, in denen nicht immer sicher zwischen echtem therapeutischem Effekt einerseits, und der Selektion von Patienten mit ohnehin g\u00fcnstigeren Verl\u00e4ufen andererseits unterschieden werden kann. Die Durchf\u00fchrung randomisierter Studien w\u00e4re hilfreich, um die Indikationen genauer abzugrenzen, st\u00f6\u00dft aber auf verschiedene, unter anderem logistische Hindernisse. <\/jats:p>","DOI":"10.1024\/0040-5930.58.12.726","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:21:54Z","timestamp":1138710114000},"page":"726-731","source":"Crossref","is-referenced-by-count":4,"title":["Metastasectomy \u2013 are its benefits chiefly and directly linked to surgery as such, or caused by patient selection and other confounding factors?"],"prefix":"10.1024","volume":"58","author":[{"given":"Martin F.","family":"Fey","sequence":"first","affiliation":[{"name":"Institut f\u00fcr medizinische Onkologie, Universit\u00e4t und Inselspital, Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rauch","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr medizinische Onkologie, Universit\u00e4t und Inselspital, Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930.58.12.726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:48:58Z","timestamp":1652006938000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930.58.12.726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12,1]]}},"alternative-id":["10.1024\/0040-5930.58.12.726"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930.58.12.726","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,12,1]]}}}