{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:53:24Z","timestamp":1761058404992},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2002,10,1]]},"abstract":"<jats:p> Calcium Pyrophosphat Dihydrat (CPPD) Kristalle lagern sich in fibr\u00f6sem und hyalinem Gelenkknorpel (Chondrokalzinose), Gelenkkapseln, Synovium, Schleimbeuteln, Sehnenscheiden, Sehnen und B\u00e4ndern ab. Diese mit steigendem Alter an H\u00e4ufigkeit zunehmenden Ablagerungen k\u00f6nnen asymptomatisch bleiben oder sich als akute Pseudogicht Arthritis, pseudorheumatoide Arthritis, Bursitis, Tenosynovitis, Tendinitis, polymyalgisches Syndrom und Pyrophosphat Arthropathie manifestieren. Die Diagnose der Calcium Pyrophosphat Ablagerungserkrankung beruht auf dem polarisationsmikroskopischen Nachweis intrazellul\u00e4rer CPPD Kristalle in der aspirierten Synovia, den charakteristischen radiologischen Ver\u00e4nderungen und den vielgestaltigen klinischen Pr\u00e4sentationen. Die Behandlung erfolgt symptom-orientiert und zus\u00e4tzlich krankheitsspezifisch im Falle einer zugrundeliegenden metabolischen Erkrankung wie H\u00e4mochromatose, Hyperparathyreoidismus, Hypophosphatasie, Hypomagnesi\u00e4mie und Hypothyreose. <\/jats:p>","DOI":"10.1024\/0040-5930.59.10.523","type":"journal-article","created":{"date-parts":[[2006,1,31]],"date-time":"2006-01-31T12:22:36Z","timestamp":1138710156000},"page":"523-528","source":"Crossref","is-referenced-by-count":5,"title":["Calcium pyrophosphate dihydrate deposition disease"],"prefix":"10.1024","volume":"59","author":[{"family":"Beyeler","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Rheumatologie und Klinische Immunologie\/Allergologie, Universit\u00e4tsspital Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930.59.10.523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:42:27Z","timestamp":1652006547000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930.59.10.523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2002,10,1]]}},"alternative-id":["10.1024\/0040-5930.59.10.523"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930.59.10.523","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10,1]]}}}