{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T18:58:12Z","timestamp":1694631492148},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:p> Er wird zur Zeit gesch\u00e4tzt, dass 25\u201330% aller Mammakarzinome einen famili\u00e4ren Hintergrund haben. Das Brustkrebslebenszeitrisiko erstgradig Verwandter mit einer Mammakarzinom-Familienanamnese kann je nach genetischem Hintergrund gegen\u00fcber dem Bev\u00f6lkerungsrisiko als leicht, m\u00e4\u00dfig oder stark erh\u00f6ht eingesch\u00e4tzt werden. Individuen aus Familien mit stark erh\u00f6htem Brustkrebsrisiko sollten eine genetische Beratung und Testung angeboten bekommen. In der folgenden \u00dcbersicht werden die Elemente der genetischen Beratung und Testung und das Management von Familien mit vererbtem Brust- und Eierstockkrebsrisiko besprochen. <\/jats:p>","DOI":"10.1024\/0040-5930.65.4.235","type":"journal-article","created":{"date-parts":[[2008,3,28]],"date-time":"2008-03-28T03:30:25Z","timestamp":1206675025000},"page":"235-241","source":"Crossref","is-referenced-by-count":0,"title":["Genetische Beratung beim famili\u00e4ren Mammakarzinom"],"prefix":"10.1024","volume":"65","author":[{"given":"Gabriella","family":"Pichert","sequence":"first","affiliation":[{"name":"Oncocare Klinik Engeried, Bern"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930.65.4.235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:33:51Z","timestamp":1652006031000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930.65.4.235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4,1]]}},"alternative-id":["10.1024\/0040-5930.65.4.235"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930.65.4.235","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,4,1]]}}}