{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:25:17Z","timestamp":1771547117565,"version":"3.50.1"},"reference-count":0,"publisher":"Hogrefe Publishing Group","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutische Umschau"],"published-print":{"date-parts":[[2009,4,1]]},"abstract":"<jats:p> Die durch Atherosklerose verursachte Koronare Herzkrankheit (KHK) ist die h\u00e4ufigste Todesursache in den Industrienationen, sodass ihre Pr\u00e4vention eine wichtige medizinische Aufgabe ist. Klassische Risikofaktoren, wie z.B. Alter, Rauchen und Cholesterinspiegel erlauben vor allem durch Anwendung von Algorithmen oder Scores das Risiko f\u00fcr ein kardiovaskul\u00e4res Ereignis bei asymptomatischen Patienten in den n\u00e4chsten zehn Jahren abzusch\u00e4tzen. Allerdings sind die gegenw\u00e4rtigen Methoden vor allem in Bezug auf ihre prognostische Sensitivit\u00e4t und positive pr\u00e4diktive Wertigkeit eingeschr\u00e4nkt. Deswegen werden neue Risikofaktoren und Biomarker gesucht, um die Risikostratifizierung zu verbessern. Diese \u00dcbersicht beschreibt die Risikostratifizierung der KHK und einige wichtige neue Biomarker. <\/jats:p>","DOI":"10.1024\/0040-5930.66.4.253","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T02:30:51Z","timestamp":1239157851000},"page":"253-259","source":"Crossref","is-referenced-by-count":5,"title":["Risikofaktoren der koronaren Herzkrankheit"],"prefix":"10.1024","volume":"66","author":[{"given":"Danielle","family":"Hof","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Klinische Chemie, Universit\u00e4tsSpital, Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnold","family":"von Eckardstein","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Klinische Chemie, Universit\u00e4tsSpital, Z\u00fcrich"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"101","container-title":["Therapeutische Umschau"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0040-5930.66.4.253","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T10:35:23Z","timestamp":1652006123000},"score":1,"resource":{"primary":{"URL":"https:\/\/econtent.hogrefe.com\/doi\/10.1024\/0040-5930.66.4.253"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4,1]]}},"alternative-id":["10.1024\/0040-5930.66.4.253"],"URL":"https:\/\/doi.org\/10.1024\/0040-5930.66.4.253","relation":{},"ISSN":["0040-5930","1664-2864"],"issn-type":[{"value":"0040-5930","type":"print"},{"value":"1664-2864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,1]]}}}