{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:02:43Z","timestamp":1723248163880},"reference-count":0,"publisher":"IMR Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:p> Vitamin C is crucial for the brain. We aimed to investigate the effects of vitamin C administration following 24 hours of acute food deprivation and 24 hours of acute food intake on changes in vitamin C levels in different brain areas of guinea pigs. Vitamin C was administered as a single intraperitoneal dose (500 mg kg<jats:sup>-1<\/jats:sup> body weight) both before acute food deprivation and before acute food intake. At the end of our study, we measured the vitamin C levels in cerebral cortex lobes, brain stem structures, hypophysis, hypothalamus, cerebellum, hippocampus, and amygdala. Vitamin C levels in the frontal and parietal lobes were found to be significantly higher in animals pretreated with vitamin C prior to 24 hours of food deprivation (p &lt; 0.05). Temporal lobe vitamin C level was significantly lower in animals that were subjected to 24 hours of acute food intake following 24 hours of food deprivation (p &lt; 0.05). Increased vitamin C levels were observed in the occipital lobe of all animals that received vitamin C administration (p &lt; 0.05). Vitamin C levels in the brain stem structures such as mesencephalon and pons were significantly decreased in animals pretreated with vitamin C before normal feeding (p &lt; 0.05). Vitamin C level in the hypothalamus was significantly increased after 24 hours of food deprivation (p &lt; 0.05). In conclusion, different areas of the brain may differ in terms of vitamin C content during nutritional changes with or without vitamin C pretreatment, such as 24 hours of food deprivation or 24 hours of food intake following 24 hours of food deprivation. These differences may be attributed to several functions of vitamin C which may occur under these circumstances. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000016","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T03:32:39Z","timestamp":1294889559000},"page":"197-204","source":"Crossref","is-referenced-by-count":1,"title":["The Effects of Vitamin C Administration, Acute Food Deprivation, and Acute Food Intake on Vitamin C Levels in Different Brain Areas of Guinea Pigs"],"prefix":"10.31083","volume":"80","author":[{"given":"Birsen","family":"Kaplan","sequence":"first","affiliation":[{"name":"Gazi University, Vocational School of Health Services, G\u00f6lbasi, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferihan","family":"\u00c7etin","sequence":"additional","affiliation":[{"name":"Dokuz Eyl\u00fcl University, School of Physical Medicine and Rehabilitation, Inciralti-Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sehri","family":"Elbeg","sequence":"additional","affiliation":[{"name":"Gazi University, Faculty of Medicine, Department of Medical Biochemistry, Besevler, Ankara, Turkey,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:10:46Z","timestamp":1723169446000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/80\/3\/10.1024\/0300-9831\/a000016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6,1]]}},"alternative-id":["10.1024\/0300-9831\/a000016"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000016","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[2010,6,1]]}}}