{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:28:54Z","timestamp":1789504134298,"version":"build-2803163510"},"reference-count":0,"publisher":"IMR Press","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2010,6,1]]},"abstract":"<jats:p> Background &amp; Aims: To investigate the effect of vitamin A supplementation on parameters of the immune system of vitamin A-deficient children. Methods: The study was carried out in four phases: 1) determination of serum retinol in 631 children from 36 to 83 months of age; 2) assessment of immunological markers [immunoglobulins and complement fractions, immunophenotyping of T and B lymphocytes, and natural killer (NK) cells], blood count, and serum ferritin of 52 vitamin A-deficient children (serum retinol &lt; 0.70 \u00b5mol\/L); 3) supplementation of the 52 deficient children with 200,000 IU of vitamin A; 4) determination of serum retinol and the immunological parameters 2 months after vitamin A supplementation. Results: Before vitamin A supplementation, 24.0 % of the children were anemic and 4.3 %had reduced ferritin concentrations. There was no significant difference between mean values of retinol according to the presence\/absence of anemia. The mean values of the humoral and cellular immunological parameters did not show a statistically significant difference before and after supplementation with vitamin A. Children with concomitant hypovitaminosis A and anemia presented a significant increase in absolute CD4 and CD8 T-cell counts after vitamin A supplementation (p &lt; 0.05). Conclusion: Vitamin A had an effect on the recruitment of T and B lymphocytes to the circulation of children with hypovitaminosis A and anemia. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000017","type":"journal-article","created":{"date-parts":[[2011,1,13]],"date-time":"2011-01-13T03:32:39Z","timestamp":1294889559000},"page":"188-196","source":"Crossref","is-referenced-by-count":12,"title":["The Impact of Vitamin A Supplementation on the Immune System of Vitamin A-deficient Children"],"prefix":"10.31083","volume":"80","author":[{"given":"Adriana","family":"de Azevedo Paiva","sequence":"first","affiliation":[{"name":"Department of Nutrition, Federal University of Teresina, Piaui, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Helen","family":"Rond\u00f3","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, SP, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Rehder Vaz-de-Lima","sequence":"additional","affiliation":[{"name":"Section of Immunology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmem","family":"de Freitas Oliveira","sequence":"additional","affiliation":[{"name":"Serology, and Medical Biology of Adolfo Lutz Institute, Sao Paulo, SP, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirthes","family":"Ueda","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Federal University of Piaui, Teresina, Piau\u00ed, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Gon\u00e7alves-Carvalho","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Campina Grande, Campina Grande, Paraiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Gustavo","family":"Reinaldo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Federal University of Campina Grande, Campina Grande, Paraiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:10:45Z","timestamp":1723169445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/80\/3\/10.1024\/0300-9831\/a000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,6,1]]}},"alternative-id":["10.1024\/0300-9831\/a000017"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000017","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,1]]}}}