{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T18:48:07Z","timestamp":1767898087493,"version":"3.49.0"},"reference-count":0,"publisher":"IMR Press","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p> Background: Although aflatoxin exposure has been associated with micronutrient deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans. Objective: To examine the relationship between aflatoxin B<jats:sub>1<\/jats:sub> (AFB<jats:sub>1<\/jats:sub>) albumin adducts (AF-ALB) in plasma and the aflatoxin M<jats:sub>1<\/jats:sub> (AFM<jats:sub>1<\/jats:sub>) metabolite in urine and plasma concentrations of retinol (vitamin A) and alpha-tocopherol (vitamin E) in Ghanaians. Methods: A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels. Results: Multivariable analysis showed that participants with high AF-ALB (&gt;= 0.80 pmol\/mg albumin) had increased odds of having vitamin A deficiency compared to those with lower AF-ALB [Odds Ratio (OR) = 2.61; CI = 1.03 - 6.58; p = 0.04]. Participants with high AF-ALB also showed increased odds of having vitamin E deficiency but this was not statistically significant (OR = 2.4; CI = 0.96 - 6.05; p = 0.06). Conversely, those with higher AFM<jats:sub>1<\/jats:sub> values had a statistically nonsignificant reduced odds of having vitamin A deficiency (OR = 0.31; CI = 0.09 - 1.02; p = 0.05) and a statistically significant reduced odds of having vitamin E deficiency (OR = 0.31; CI = 0.10 - 0.97; p = 0.04). Participants with high AF-ALB or high AFM<jats:sub>1<\/jats:sub> (&gt;= 437.95 pg\/dL creatinine) were almost 6 times more likely to be hepatitis B virus surface antigen (HBsAg)-positive (OR = 5.88; CI = 1.71 - 20.14; p = 0.005) and (OR = 5.84; CI = 1.15 - 29.54; p = 0.03) respectively. Conclusions: These data indicate that aflatoxin may modify plasma micronutrient status. Thus, preventing aflatoxin exposure may reduce vitamin A and E deficiencies. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000021","type":"journal-article","created":{"date-parts":[[2013,2,2]],"date-time":"2013-02-02T02:23:04Z","timestamp":1359771784000},"page":"355-368","source":"Crossref","is-referenced-by-count":23,"title":["Aflatoxin B<sub>1<\/sub> albumin adducts in plasma and aflatoxin M<sub>1<\/sub> in urine are associated with plasma concentrations of vitamins A and E"],"prefix":"10.31083","volume":"80","author":[{"given":"Francis A.","family":"Obuseh","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health, University of Alabama at Birmingham, Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline E.","family":"Jolly","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal M.B.","family":"Shuaib","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Waterbor","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William O.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandrika J.","family":"Piyathilake","sequence":"additional","affiliation":[{"name":"Nutritional Biochemistry and Genomics, University of Alabama at Birmingham, School of Health Professions, Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renee A.","family":"Desmond","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evans","family":"Afriyie-Gyawu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Texas A & M, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy D.","family":"Phillips","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Texas A & M, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:10:36Z","timestamp":1723169436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/80\/6\/10.1024\/0300-9831\/a000021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,12,1]]}},"alternative-id":["10.1024\/0300-9831\/a000021"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000021","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}