{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:01:46Z","timestamp":1772233306024,"version":"3.50.1"},"reference-count":0,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:p> Background: Some studies have hypothesized the protective role of vitamin C against cardiovascular disorders (CVD) in patients with end-stage renal disease (ESRD). This study was designed to assess plasma vitamin C concentration and its relationship to hemodialysis (HD) patients\u0092 morbidity and mortality. Methods: Plasma vitamin C concentrations were assessed in HD patients using spectrophotometry and subjects were prospectively followed for up eighteen months for all-cause mortality. Any association between vitamin C concentration and patients\u0092 demographic data, co-morbidities, or the cause of ESRD were investigated using the Chi-square test. Results: Ninety-one patients with a mean age of 56.7 \u00b1 15.7 years were included in this study. The most frequent cause of ESRD was simultaneous hypertension and diabetes in 30 % of patients, followed by hypertension in 25.6 %, and diabetes in 11.1 %, respectively. About 34 % of patients had CVD as the most prevalent co-morbidity. Forty-nine patients (53.8 %) had low levels of vitamin C concentration. There was a significant relationship between vitamin C insufficiency and presence of any co-morbidity in HD patients (p &lt; 0.05). There was a significant difference in vitamin C concentrations between patients without co-morbidities and those with cardiovascular ones (F[2,88]=3.447, p = 0.036). Twenty-two (24.2 %) patients died over a median duration of 227 days. There was a significant difference in time to death of patients with and without low levels of vitamin C concentration (p = 0.04). Conclusions: The results showed lower plasma vitamin C levels in HD patients who suffered any co-morbidity and sooner time to death in these patients. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000065","type":"journal-article","created":{"date-parts":[[2013,2,2]],"date-time":"2013-02-02T02:22:31Z","timestamp":1359771751000},"page":"197-203","source":"Crossref","is-referenced-by-count":11,"title":["Plasma Vitamin C Concentrations in Patients on Routine Hemodialysis and its Relationship to Patients\u0092 Morbidity and Mortality"],"prefix":"10.31083","volume":"81","author":[{"given":"Simin","family":"Dashti-Khavidaki","sequence":"first","affiliation":[{"name":"Nephrology Research Center and Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azita","family":"Hajhossein Talasaz","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Tabeefar","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mannan","family":"Hajimahmoodi","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghazaleh","family":"Moghaddam","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Khalili","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboob","family":"Lessan-Pezeshki","sequence":"additional","affiliation":[{"name":"Nephrology Research Center, Imam-Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsaneh","family":"Jahanmardi","sequence":"additional","affiliation":[{"name":"Imam-Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:10:21Z","timestamp":1723169421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/81\/4\/10.1024\/0300-9831\/a000065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,7,1]]}},"alternative-id":["10.1024\/0300-9831\/a000065"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000065","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}