{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:03:08Z","timestamp":1770220988842,"version":"3.49.0"},"reference-count":0,"publisher":"IMR Press","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:p> Context: Plasma total homocysteine (tHcy) is higher in men than women. Objective: To explore the gender differences in tHcy in relation to determinants of one-carbon metabolism in Indian people with low B<jats:sub>12<\/jats:sub> and adequate folate. Setting: The study took place in rural and urban areas of Pune, India. Design and participants: Participants were 441 men from the cross-sectional Coronary Risk of Insulin Sensitivity in Indian Subjects study (CRISIS) and premenopausal wives of 146 men (median ages 38 and 34 years, respectively). Main outcome measures: Gender difference in fasting tHcy in relation to plasma albumin and creatinine concentrations, lifestyle factors, diet and lean mass, plasma B12 and red cell folate (RCF) was assessed. Results: Prevalence of high tHcy (&gt; 15 \u00b5mol\/L, median 14.4 \u00b5M) was 40 %, low B12 (&lt; 150 pmol\/L, 114 pmol\/L) 66 %, and low RCF (&lt; 283 nmol\/L, 525 nmol\/L) 8 %. Men had higher (1.8x) plasma tHcy concentrations (16.2 \u00b5mol\/L) than women (9.5 \u00b5mol\/L). Only 50 % of the gender difference was explained by age, lean mass, B12, and RCF. The difference remained after controlling for other explanatory variables. Women with a tHcy of 9.3 \u00b5M had the same B12 concentration (129 pmol\/L) as men with a tHcy of 15 \u00b5M; and for a tHcy of 10.0 \u00b5mol\/L women had the same RCF concentration (533 nmol\/L) as men with a tHcy of 15 \u00b5mol\/L. Conclusions: Adult Indian women have markedly lower tHcy concentrations compared to men. This suggests a lower threshold for supplementation to improve reproductive and cardiovascular outcomes. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000078","type":"journal-article","created":{"date-parts":[[2013,2,2]],"date-time":"2013-02-02T02:22:37Z","timestamp":1359771757000},"page":"306-316","source":"Crossref","is-referenced-by-count":14,"title":["Marked Gender Difference in Plasma Total Homocysteine Concentrations in Indian Adults with low Vitamin B<sub>12<\/sub>"],"prefix":"10.31083","volume":"81","author":[{"given":"Sadanand","family":"Naik","sequence":"first","affiliation":[{"name":"Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charudatta","family":"Joglekar","sequence":"additional","affiliation":[{"name":"Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dattatray","family":"Bhat","sequence":"additional","affiliation":[{"name":"Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himangi","family":"Lubree","sequence":"additional","affiliation":[{"name":"Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonali","family":"Rege","sequence":"additional","affiliation":[{"name":"Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kondiba","family":"Raut","sequence":"additional","affiliation":[{"name":"Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prachi","family":"Katre","sequence":"additional","affiliation":[{"name":"Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine","family":"Rush","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity and Nutrition Research, Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chittaranjan","family":"Yajnik","sequence":"additional","affiliation":[{"name":"Diabetes Unit, King Edward Memorial Hospital Research Centre, Pune, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:10:18Z","timestamp":1723169418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/81\/5\/10.1024\/0300-9831\/a000078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,9,1]]}},"alternative-id":["10.1024\/0300-9831\/a000078"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000078","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,1]]}}}