{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:21:38Z","timestamp":1791292898544,"version":"4.1.0"},"reference-count":0,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p> Introduction: The purpose of this study was to evaluate the B-6 vitamers in plasma and related symptoms in hemodialysis subjects taking high- or low-dose vitamins. Methods: A total of 24 hemodialysis (HD) subjects were divided into two groups. Twelve subjects received a high-dose vitamin supplement [50 mg pyridoxine hydrochloride (PN-HCl) \/tablet] and 12 received a low-dose vitamin supplements containing (10 mg PN-HCl\/tablet) for 6+ months. Plasma B-6 vitamers were analyzed using HPLC. Other data were obtained from subjects\u0092 medical records. Subjects were assessed for vitamin B-6 related symptoms. Cluster analysis was used to form symptom groups. Student t-tests and analysis of variance were used to determine differences (p &lt; 0.05) in group means. Results: The mean \u00b1SD plasma B-6 vitamer and 4-pyridoxic acid concentrations (nmol\/L) were as follows in the 10-mg and 50-mg PN-HCl groups, respectively: pyridoxal- 5\u0092-phosphate (PLP) 10 \u00b1 3 and 16 \u00b1 8 (p = 0.04); pyridoxal (PL) 50 \u00b1 96 and 68 \u00b1 06; pyridoxine (PN) 26 \u00b1 50 and 191 \u00b1 107; and 4-pyridoxic acid (4-PA) 43 \u00b1 64 and 99 \u00b1 361. The cluster group with a significantly higher (p = 0.04) plasma 4-PA concentration of 167 \u00b1 697 nmol\/L reported more tingling hands, tachycardia, and diarrhea. Conclusion: Plasma PLP levels and symptoms related to B-6 in HD subjects are impacted by dose of PN-HCl. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000102","type":"journal-article","created":{"date-parts":[[2013,2,2]],"date-time":"2013-02-02T02:23:14Z","timestamp":1359771794000},"page":"130-136","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin B-6 Vitamer Levels in Plasma and Related Symptoms in Hemodialysis Subjects Taking low- and High-Dose Renal Multivitamin Supplements"],"prefix":"10.31083","volume":"82","author":[{"family":"Clement","sequence":"first","affiliation":[{"name":"South Plains Kidney Disease Center, Lubbock, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Boylan","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Hospitality, and Retailing, Texas Tech University, Lubbock, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Miller","sequence":"additional","affiliation":[{"name":"School of Nursing, Texas Tech University Health Sciences Center, Lubbock, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Driskell","sequence":"additional","affiliation":[{"name":"University of Nebraska, Lincoln, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Giraud","sequence":"additional","affiliation":[{"name":"University of Nebraska, Lincoln, NE, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Subih","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Hospitality, and Retailing, Texas Tech University, Lubbock, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:10:07Z","timestamp":1723169407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/82\/2\/10.1024\/0300-9831\/a000102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4,1]]}},"alternative-id":["10.1024\/0300-9831\/a000102"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000102","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,1]]}}}