{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:02:26Z","timestamp":1723248146644},"reference-count":0,"publisher":"IMR Press","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2012,8,1]]},"abstract":"<jats:p> Background: Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on homocysteine response to a mixed nutrient supplement in older patients. A raised plasma homocysteine concentration in older patients is partly a reflection of their co-morbidity, including impaired renal function, and there is uncertainty about the extent to which dietary interventions can improve plasma tHcy. Aim: To determine the plasma tHcy response to dietary supplements during acute illness. Methods: Two-hundred and thirty-six hospitalized, acutely ill older patients, who were part of a randomized double-blind placebo-controlled trial, were assigned to receive a daily oral nutritional supplement drink containing 1.3 mg of vitamin B<jats:sub>2<\/jats:sub>, 1.4 mg of vitamin B<jats:sub>6,<\/jats:sub> 1.5 \u03bcg of B<jats:sub>12,<\/jats:sub> 200 \u03bcg of folic acid, or a placebo, for 6 weeks. Outcome measures were plasma tHcy concentration at baseline, 6 weeks, and 6 months. Results: The mean plasma tHcy concentration fell among patients given the supplements (mean difference 4.1 \u00b5mol\/L [95 % C.I, 0.14 to 8.03), p = 0.043], but tHcy concentration increased between 6 weeks and 6 months, after patients stopped taking the supplements [mean difference -2.0 \u00b5mol\/L (95 % C.I, -03.9 to -0.18), p = 0.033]. About 46 % of patients in the placebo group and 55 % of patients in the supplement group had hyperhomocysteinemia (&gt;14 \u00b5mol\/L) at baseline compared with 45 % and 29 % at the end of the treatment period. Conclusions: A mixed nutrient supplement containing physiological amounts of B vitamins significantly reduced plasma tHcy concentrations in older patients recovering from acute illness. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000118","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T01:51:03Z","timestamp":1366163463000},"page":"260-266","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Mixed Dietary Supplements on Total Plasma Homocysteine Concentrations (tHcy): A Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.31083","volume":"82","author":[{"given":"Salah E.","family":"Gariballa","sequence":"first","affiliation":[{"name":"Internal Medicine, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Forster","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, School of Medicine and Biomedical Sciences, University of Sheffield, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary J.","family":"Powers","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit, School of Medicine and Biomedical Sciences, University of Sheffield, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:09:55Z","timestamp":1723169395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/82\/4\/10.1024\/0300-9831\/a000118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8,1]]}},"alternative-id":["10.1024\/0300-9831\/a000118"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000118","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[2012,8,1]]}}}