{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:39:56Z","timestamp":1788572396105,"version":"build-2803163510"},"reference-count":0,"publisher":"IMR Press","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2013,4,1]]},"abstract":"<jats:p>\n                    For decades, vitamin D has been known to be essential in the development, function, and maintenance of healthy bones through the regulation of calcium homeostasis throughout life. Sufficient vitamin D prevents the occurrence of rickets in children and osteomalacia in adults. The adequate nutritional intake of vitamin D and calcium are the basis for the prevention and management of osteoporosis, a disease producing brittle bones that are prone to fractures. Vitamin D has been implicated in the regulation of neuromuscular function and in reducing the risk of falls, a major cause of bone fractures. Thus vitamin D may be a central component of musculoskeletal health through its beneficial effects on muscle function and bone stability. The action of vitamin D by the active metabolite 1,25-dihydroxyvitamin D [1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D], however, is not limited to its endocrine function in bone metabolism. The active metabolite behaves as a hormone and binds to the vitamin D receptor (VDR) present in nearly all tissues of the human body. In addition, the 1-alpha-hydroxylase enzyme is present not only in the kidney but also in many other organs. Both vitamin and enzyme exert their biological effects via paracrine\/autocrine actions related to cardiovascular disease, diabetes, cancer, and the immune system. Thus vitamin D may show favorable effects in many organs and play a significant role in the maintenance of general health.\n                  <\/jats:p>","DOI":"10.1024\/0300-9831\/a000151","type":"journal-article","created":{"date-parts":[[2014,2,3]],"date-time":"2014-02-03T21:07:44Z","timestamp":1391461664000},"page":"92-100","source":"Crossref","is-referenced-by-count":47,"title":["Vitamin D, an Essential Nutrient with Versatile Functions in Nearly all Organs"],"prefix":"10.31083","volume":"83","author":[{"given":"Elisabeth","family":"St\u00f6cklin","sequence":"first","affiliation":[{"name":"DSM Nutritional Products Ltd., Kaiseraugst, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Eggersdorfer","sequence":"additional","affiliation":[{"name":"DSM Nutritional Products Ltd., Kaiseraugst, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T22:09:42Z","timestamp":1723154982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/83\/2\/10.1024\/0300-9831\/a000151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4,1]]}},"alternative-id":["10.1024\/0300-9831\/a000151"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000151","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"value":"0300-9831","type":"print"},{"value":"1664-2821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,1]]}}}