{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:03:47Z","timestamp":1723248227684},"reference-count":0,"publisher":"IMR Press","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:p> The aim of this study was to investigate the real impact of dietary lipids on metabolic and inflammatory response in rat white adipose tissue. Male healthy Wistar rats were fed ad libitum with a control diet (CON, n=12) or with an adjusted high-fat diet (HFD, n=12) for 12 weeks. Oral glucose and insulin tolerance tests were performed during the last week of the protocol. Plasma fatty acid, lipid profile, body adiposity, and carcass chemical composition were analyzed. Plasma concentration of leptin, adiponectin, C-reactive protein (CRP), TNF-\u03b1, IL-6, and monocyte chemotactic protein (MCP-1) was measured. Periepididymal adipose tissue was employed to evaluate TNF-\u03b1, MCP-1, and adiponectin gene expression as well as NF-\u03baB pathway and AKT proteins. Isocaloric intake of the adjusted HFD did not induce hyperphagia, but promoted an increase in periepididymal (HFD = 2.94 \u00b1 0.77 vs. CON = 1.99 \u00b1 0.26 g\/100 g body weight, p = 0.01) and retroperitoneal adiposity (HFD = 3.11 \u00b1 0.81 vs. CON = 2.08 \u00b1 0.39 g\/100 g body weight, p = 0.01) and total body lipid content (HFD = 105.3 \u00b1 20.8 vs. CON = 80.5 \u00b1 7.6 g carcass, p = 0.03). Compared with control rats, HFD rats developed glucose intolerance (p=0.01), dyslipidemia (p = 0.02) and exhibited higher C-reactive protein levels in response to the HFD (HFD = 1002 \u00b1 168 vs. CON = 611 \u00b1 260 ng\/mL, p = 0.01). The adjusted HFD did not affect adipokine gene expression or proteins involved in inflammatory signaling, but decreased AKT phosphorylation after insulin stimulation in periepididymal adipose tissue (p = 0.01). In this study, nutrient-adjusted HFD did not induce periepididymal adipose tissue inflammation in rats, suggesting that the composition of HFD differently modulates inflammation in rats, and adequate micronutrient levels may also influence inflammatory pathways. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000172","type":"journal-article","created":{"date-parts":[[2014,10,11]],"date-time":"2014-10-11T01:10:45Z","timestamp":1412989845000},"page":"299-310","source":"Crossref","is-referenced-by-count":2,"title":["Nutrient-Adjusted High-Fat Diet is Associated with Absence of Periepididymal Adipose Tissue Inflammation: Is there a Link with Adequate Micronutrient Levels?"],"prefix":"10.31083","volume":"83","author":[{"given":"Monica","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Maintinguer Norde","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Borges","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane","family":"Mieko de Meneses Fujii","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Silva Jacob","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam H.","family":"Fonseca-Alaniz","sequence":"additional","affiliation":[{"name":"Heart Institute of the S\u00e3o Paulo University Medical School, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I.","family":"Cardoso Alonso-Vale","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco L.","family":"Torres-Leal","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Tirapegui","sequence":"additional","affiliation":[{"name":"Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, S\u00e3o Paulo University, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A.","family":"Fock","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Primavera","family":"Borelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Curi","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Macedo Rogero","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health, University of S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:09:21Z","timestamp":1723169361000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/83\/5\/10.1024\/0300-9831\/a000172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10,1]]}},"alternative-id":["10.1024\/0300-9831\/a000172"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000172","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[2013,10,1]]}}}