{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:23:38Z","timestamp":1740144218109,"version":"3.37.3"},"reference-count":47,"publisher":"IMR Press","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2018,2,1]]},"abstract":"<jats:p>Abstract. Cardiovascular disease (CVD) risk factors, such as bad eating habits, are typical in adolescence and lead to the consumption of meals that are not always sufficient in vitamins A, E, \u03b2-carotene, excess calories and elevated serum leptin levels. The purpose of this research is to study the relationship between vitamin A deficiency (VAD), \u03b2-carotene deficiency (\u03b2cD), vitamin E deficiency (VED) and to explore the association of leptin receptor Q223R polymorphisms with obesity and other risk factors for CVD. Method: This observational study included 237 adolescents recruited from Adolescents Reference Center, Brazil. It was collected: socioeconomic and clinical data, laboratory and molecular samples. Results: The average age was 14.93 \u00b1 2.18 years, 66.2 % were girls, 38.0 % had high levels of total cholesterol (TC) between 10\u201314 years Triceps (TSF) and subscapular skinfolds (SSF) measurements were inversely correlated with VAD. There was also an association between VAD, \u03b2cD and high triglyceride (TG) levels. Adolescents with the RR genotype presented a trend toward higher levels of body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), TC, TG, low density lipoprotein (LDLC), leptin and low levels of high-density lipoprotein (HDL-c). Conclusion: The girls had higher levels of leptin than boys. Abdominal fat, \u03b2cD and VED were observed in adolescents with VAD. Individuals with RR genotype have drawn attention to cardiovascular risk factors such as high rate of LDLC and reduced rate of HDLc. Thus, it is possible that individuals with this genotype may be more susceptible to the presence of cardiovascular risk factors.<\/jats:p>","DOI":"10.1024\/0300-9831\/a000274","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T06:54:12Z","timestamp":1555311252000},"page":"27-38","source":"Crossref","is-referenced-by-count":3,"title":["Anthropometric Profile, Serum Leptin, Antioxidant Vitamins, LEPR Q223R Polymorphism and Cardiovascular Risk Factors in Adolescents"],"prefix":"10.31083","volume":"88","author":[{"given":"Maria Nubia","family":"Gama Oliveira","sequence":"first","affiliation":[{"name":"Adolescents Reference Center of the Municipal Health of the City of Maca\u00e9 and State Health Secretariat, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glorimar","family":"Rosa","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Federal University of Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Jo\u00e3o Mansure","sequence":"additional","affiliation":[{"name":"Departament of Urology, Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane","family":"Wagner Ramos","sequence":"additional","affiliation":[{"name":"Maca\u00e9 Municipal Government, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique","family":"Godoy","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery Federal University of Rio de Janeiro State, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"c1","doi-asserted-by":"crossref","unstructured":"Schneider A. 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