{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T03:30:25Z","timestamp":1752982225386},"reference-count":55,"publisher":"IMR Press","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p> Abstract. A lower serum folate level is common in older populations and is associated with increased serum homocysteine concentration. In turn, an elevated homocysteine level is associated with increased risk of cardiovascular disease and age-related diseases. Contemporary studies of folate and dietary risk factors for cardiovascular disease among the elderly population in Thailand are lacking. This cross-sectional study aimed to investigate the relationships among serum folate, homocysteine level, and nutritional status in the elderly Thai. Three hundred individuals, aged 60\u00a0years and over, underwent anthropometric and physiological measurements, and biochemical parameters, and eating habits were also determined. Folate insufficiency was found in approximately 35% of subjects. Folate and homocysteine showed a significant inverse correlation. Serum homocysteine levels rose with increasing age. Folate deficiency and high waist-to-hip ratio were associated with 7-fold and 2.5-fold increased risk for hyperhomocysteinemia, respectively. There were positive correlations between homocysteine and waist-to-hip ratio and systolic blood pressure, but a negative correlation between homocysteine and high-density lipoprotein ( r\u00a0=\u00a0\u22120.239, p\u00a0&lt;\u00a00.01), which are markers for cardiovascular disease risk. Folate negatively correlated with body mass index, waist-to-hip ratio, and diastolic blood pressure, but positively with high-density lipoprotein ( r\u00a0=\u00a00.162, p\u00a0&lt;\u00a00.01). Investigation of eating habits showed that low consumption of green leafy vegetables and high consumption of sugary foods were associated with high homocysteine levels. Given associations between nutritional status and cardiovascular disease confirmed in this study, nutrition education, holistic health promotion, and appropriate behavioral modification of eating habits represent important measures for preventing premature cardiovascular disease in the elderly Thai population. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000402","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T08:44:40Z","timestamp":1555317880000},"page":"246-254","source":"Crossref","is-referenced-by-count":4,"title":["Associations among serum folate, waist-to-hip ratio, lipid profile, and eating habits with homocysteine in an elderly Thai population"],"prefix":"10.31083","volume":"89","author":[{"given":"Chirawat","family":"Paratthakonkun","sequence":"first","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"},{"name":"College of Sports Science and Technology, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarunya","family":"Kaewprasert","sequence":"additional","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dumrongkiet","family":"Arthan","sequence":"additional","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngamphol","family":"Soonthornworasiri","sequence":"additional","affiliation":[{"name":"Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rungsunn","family":"Tungtrongchitr","sequence":"additional","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pattaneeya","family":"Prangthip","sequence":"additional","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisara","family":"Wongsutthilerd","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Burapha University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somchai","family":"Pooudoung","sequence":"additional","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaovamarn","family":"Chantaranipapong","sequence":"additional","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyarat","family":"Nakosiri","sequence":"additional","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amornrat","family":"Aroonnual","sequence":"additional","affiliation":[{"name":"Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaowanee","family":"Chupeerach","sequence":"additional","affiliation":[{"name":"Institute of Nutrition, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siriporn","family":"Chanchai","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Burapha University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arth","family":"Nana","sequence":"additional","affiliation":[{"name":"College of Sports Science and Technology, Mahidol University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"16242","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2863(90)90070-2"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-199808000-00007"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831\/a000229"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510220049033"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-014-0537-x"},{"key":"c6","first-page":"250","volume":"14","author":"Chen K.J.","year":"2005","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"c7","first-page":"779","volume":"6","author":"Chen S.F.","year":"2013","journal-title":"Int. J. Clin. Exp. Med."},{"key":"c8","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1093\/clinchem\/39.9.1764","volume":"39","author":"Ueland P.M.","year":"1993","journal-title":"Clin. Chem."},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00512.x"},{"key":"c10","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(01)00365-7"},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000131942.77635.2D"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.3132\/dvdr.2007.033"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199104253241701"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.12.070192.001431"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.6.1731S"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.738732"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(01)00187-4"},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-9-31"},{"key":"c19","doi-asserted-by":"publisher","DOI":"10.3109\/09637480903286371"},{"key":"c20","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.1.27"},{"key":"c21","unstructured":"Mahidol University Institute for Population and Social Research (MUIPSR). (2016) Population aging in Thailand, 2016. [accessed Jan 12, 2016]. Available from: http:\/\/www.thailandometers.mahidol.ac.th\/#elderly"},{"key":"c22","unstructured":"World Health Organization (WHO) (2016) Nutrition for older persons. [accessed Jan 12, 2016]. Available from: http:\/\/www.who.int\/nutrition\/topics\/ageing\/en\/index1.html"},{"key":"c23","doi-asserted-by":"publisher","DOI":"10.1017\/S136898000720494X"},{"key":"c24","unstructured":"Health Insurance System Research Office (HISRO). Report of public health services system situation. The Third Trimester (April\u2013June 2010), pp. 1\u2013238."},{"key":"c25","first-page":"1","volume":"23","author":"Mahidol University Institute for Population and Social Research (MUIPSR)","year":"2014","journal-title":"Mahidol Population Gazette"},{"key":"c26","unstructured":"World Health Organization (WHO). (2016) Serum and red blood cell folate concentrations for assessing folate status in populations. [accessed Jan 12, 2016]. Available from: http:\/\/www.who.int\/vmnis\/indicators\/serum_RBC_folate\/en\/"},{"key":"c27","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/125.5.1371S"},{"key":"c28","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.14.4.335"},{"key":"c29","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.1.178"},{"key":"c30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000133317.49796.0E"},{"key":"c31","unstructured":"National Health Examination Survey Project (NHESO). (2011) Report on food consumption survey in Thai population. Nonthaburi: Office of NHESO, 1\u2013200."},{"key":"c32","volume-title":"Principles of Nutritional Assessment","author":"Gibson R.","year":"2005","edition":"2"},{"key":"c33","first-page":"162","volume":"7","author":"Tongboonchoo C.","year":"2015","journal-title":"J. Police Nurs."},{"key":"c34","unstructured":"Parnprathip, P. (2012) Folate status and colorectal cancer in Thais. Master\u2019s thesis. Bangkok: Mahidol University."},{"key":"c35","first-page":"275","volume":"20","author":"Chen K.J.","year":"2011","journal-title":"Asia Pac. J. Clin. Nutr."},{"key":"c36","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.6.1121"},{"key":"c37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2003.08.010"},{"key":"c38","doi-asserted-by":"publisher","DOI":"10.1300\/J052v13n04_04"},{"key":"c39","doi-asserted-by":"publisher","DOI":"10.1177\/204748739900600407"},{"key":"c40","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2013.05.019"},{"key":"c41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802037"},{"key":"c42","doi-asserted-by":"publisher","DOI":"10.1159\/000443003"},{"key":"c43","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"c44","unstructured":"World Health Organization (WHO). (2008) Waist circumference and waist-hip ratio: report of a WHO expert consultation, 1\u201339."},{"key":"c45","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-010-0165-0"},{"key":"c46","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.73.1.8"},{"key":"c47","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2008.016"},{"key":"c48","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831\/a000237"},{"key":"c49","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.6.1745"},{"key":"c50","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.216"},{"key":"c51","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000242559.42077.22"},{"key":"c52","doi-asserted-by":"publisher","DOI":"10.3390\/nu6041649"},{"key":"c53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.3.1916"},{"key":"c54","doi-asserted-by":"publisher","DOI":"10.1024\/0300-9831.77.1.22"},{"key":"c55","unstructured":"American Heart Association (AHA). (2016) Understanding blood pressure readings. [accessed Jan 12, 2016]. Available from: http:\/\/www.heart.org\/HEARTORG\/Conditions\/HighBloodPressure\/AboutHighBloodPressure\/Understanding-Blood-Pressure-Readings_UCM_301764_Article.jsp"}],"container-title":["International Journal for Vitamin and Nutrition Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/econtent.hogrefe.com\/doi\/pdf\/10.1024\/0300-9831\/a000402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T02:07:35Z","timestamp":1723169255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.imrpress.com\/journal\/IJVNR\/89\/5-6\/10.1024\/0300-9831\/a000402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":55,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1024\/0300-9831\/a000402"],"URL":"https:\/\/doi.org\/10.1024\/0300-9831\/a000402","relation":{},"ISSN":["0300-9831","1664-2821"],"issn-type":[{"type":"print","value":"0300-9831"},{"type":"electronic","value":"1664-2821"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}