{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:21:21Z","timestamp":1789176081774,"version":"build-2803163510"},"reference-count":24,"publisher":"IMR Press","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p> Abstract. Objectives: We sought to investigate associations between vitamin D levels and bowel and bladder disorders in women with vulvar diseases. <\/jats:p><jats:p> Methods: This is a planned sub-analysis of a cross-sectional study comparing the prevalence of bowel and bladder symptoms in women with biopsy-proven vulvar lichen sclerosus (LS) to a control group of women with non-lichenoid vulvar diseases. All subjects were recruited from a tertiary referral vulvar care clinic in a university-based practice. Serum vitamin D levels were measured and subjects self-completed questionnaires during study recruitment. Pelvic floor disorders were determined from the following questionnaires: Rome III Functional Bowel Disorders Questionnaire, the Bristol stool scale, the Medical, Social and Epidemiologic Aspects of Aging Questionnaire, and the Overactive Bladder-8 Question Version. <\/jats:p><jats:p> Results: 181 women with vulvar diseases were included: 88 with LS and 93 with non-LS vulvar diseases. The mean age was 52.5 \u00b1 15.3 years, and 94.5% were Caucasian. Vitamin D levels (26.8 \u00b1 13.1 vs 29.5 \u00b1 19.0 ng\/mL), prevalence of low vitamin D levels (51.1% vs 45.2%), and vitamin D supplementation (42.0% vs 47.8%) were similar in women with and without LS ( p \u2265 0.27). These factors did not differ between women with and without overactive bladder (OAB) (vitamin D levels 30.1 \u00b1 17.8 vs 26.3 \u00b1 14.8 ng\/mL), urinary incontinence (27.9 \u00b1 15.2 vs 26.4 \u00b1 11.0 ng\/mL), constipation (26.7 \u00b1 14.8 vs 28.5 \u00b1 16.8 ng\/mL), or irritable bowel syndrome (IBS) (30.8 \u00b1 22.1 vs 27.6 \u00b1 13.4 ng\/mL). <\/jats:p><jats:p> Conclusions: In this cohort of women with vulvar diseases, vitamin D levels and supplementation were not significantly different amongst women with vulvar lichen sclerosus or other non-lichenoid vulvar diseases. Furthermore, vitamin D levels are not serum biomarkers for OAB, urinary incontinence, constipation, or IBS. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000527","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T15:50:31Z","timestamp":1549986631000},"page":"266-272","source":"Crossref","is-referenced-by-count":4,"title":["Comparison of Serum Vitamin D Levels in Relation to Bowel and Bladder Symptoms in Women with Vulvar Diseases"],"prefix":"10.31083","volume":"90","author":[{"given":"Carolyn W.","family":"Swenson","sequence":"first","affiliation":[{"name":"Michigan Medicine Department of Obstetrics and Gynecology, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, 734-647-9727 (fax)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan O.","family":"Schimpf","sequence":"additional","affiliation":[{"name":"Michigan Medicine Department of Obstetrics and Gynecology, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, 734-647-9727 (fax)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy B.","family":"Menees","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Michigan Medicine Department of Internal Medicine, 1500 E. Medical Center Dr., Ann Arbor, MI 480109, 734-936-7392 (fax)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope K.","family":"Haefner","sequence":"additional","affiliation":[{"name":"Michigan Medicine Department of Obstetrics and Gynecology, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, 734-647-9727 (fax)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell B.","family":"Berger","sequence":"additional","affiliation":[{"name":"Michigan Medicine Department of Obstetrics and Gynecology, 1500 E. 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