{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:21:36Z","timestamp":1785810096940,"version":"3.56.0"},"reference-count":22,"publisher":"IMR Press","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:p> Abstract. Objective: The aim of this study was to evaluate the relationship between vitamin D levels at baseline and after 12 weeks of supplementation\/exposure to sunlight and VDR genotypes (BsmI, TaqI and ApaI) and haplotypes in a homogeneous population of postmenopausal women. <\/jats:p><jats:p> Methods: We made a prospective study in which 151 women were randomized to two groups: One with 1000\u00a0mg of calcium and 800 IU vitamin D supplementation (102 women) and a placebo group with neither calcium or vitamin D supplementation (49 women). The follow-up was from May to September 2012.Vitamin D was determined by chemiluminescent immunoassay. Genotypes were determined using the Sequenomi Plexplatform and haplotypes using PHASE software. <\/jats:p><jats:p> Results: Baseline (25\u00a0\u00b1\u00a010\u00a0ng\/ml vs.23\u00a0\u00b1\u00a09\u00a0ng\/ml, p\u00a0&gt;\u00a00.05) and 12-week (32\u00a0\u00b1\u00a08\u00a0ng\/ml vs.29\u00a0\u00b1\u00a010\u00a0ng\/ml, p\u00a0&gt;\u00a00.05) vitamin D levels were similar between the two groups. The genetic study was made in the total population. There were no differences in baseline and final levels of vitamin D in terms of genotypes and haplotypes, except for the Bat haplotype, whose baseline values were lower (25OHD: 21\u00a0\u00b1\u00a010 ng\/ml vs. 21\u00a0\u00b1\u00a010\u00a0ng\/ml, p\u00a0=\u00a00.038). The rate of nonresponders in this group was 15\u00a0% (p\u00a0=\u00a00.001), compared with 9\u00a0%, 2\u00a0% and 3\u00a0% in the other groups. <\/jats:p><jats:p> Conclusions: The Bat haplotype was associated with lower baseline levels of vitamin D and a worse response to supplementation and, therefore, may be a risk factor for vitamin D deficiency. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000534","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T17:02:54Z","timestamp":1550768574000},"page":"290-294","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Bat Vitamin D Receptor 3\u2032 Haplotypes and Vitamin D Levels at Baseline and a Lower Response After Increased Vitamin D Supplementation and Exposure to Sunlight"],"prefix":"10.31083","volume":"90","author":[{"given":"Mar\u00eda","family":"P\u00e9rez-Alonso","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laisa-Socorro","family":"Briongos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital R\u00edo Hortega, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ruiz-Mambrilla","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eladio A.","family":"Velasco","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Genetic Biology, University of Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Olmos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital Marques de Valdecilla, University of Cantabria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"de Luis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University Hospital Valladolid, University of Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Due\u00f1as-Laita","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, University Hospital R\u00edo Hortega, University of Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Luis","family":"P\u00e9rez-Castrill\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University Hospital R\u00edo Hortega, Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"16242","reference":[{"key":"c1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.04.001"},{"key":"c2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9619-0"},{"key":"c3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.05.014"},{"key":"c4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-4-200608150-00005"},{"key":"c5","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070317"},{"key":"c6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173045"},{"key":"c7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2999"},{"key":"c8","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2704"},{"key":"c9","doi-asserted-by":"publisher","DOI":"10.1086\/319501"},{"issue":"3","key":"c10","first-page":"193","volume":"51","author":"Rojo-Venegas K.","year":"2010","journal-title":"Ars Pharm."},{"key":"c11","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.953"},{"key":"c12","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2565(00)70605-9"},{"key":"c13","doi-asserted-by":"publisher","DOI":"10.1016\/S2171-9748(06)70059-9"},{"key":"c14","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0225-8"},{"key":"c15","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347196"},{"key":"c16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1389"},{"key":"c17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60588-0"},{"key":"c18","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003065"},{"key":"c19","doi-asserted-by":"crossref","unstructured":"Nieves, J., Ralston, S.H., Vasquez, E. et al. (2007) Vitamin D receptor Fokl polymorphism influences response to vitamin D supplementation in postmenopausal African-American women. In P Burckhardt, R Heaney, & B Dawson-Hughes (Eds.), Nutritional Aspects of Osteoporosis (pp. 126\u2013132). 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