{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:09:24Z","timestamp":1778314164649,"version":"3.51.4"},"reference-count":35,"publisher":"IMR Press","issue":"1-2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p> Abstract. Vitamin B12 (Cobalamin) deficiency, due to improper internalization of cobalamin, is a metabolic disorder prevalent in impoverished and elderly populations and is associated with megaloblastic anemia and dementia. It has been suggested that mutations in transcobalamin II ( TCN2) or gastric intrinsic factor (GIF) proteins can alter their binding efficiency to cobalamin or reduce the ability of their receptors to internalize them. In this case-control study, the correlation between vitamin B12 deficiency and alternative alleles of TCN2 and GIF was investigated in a Jordanian population. One hundred individuals with vitamin B12 deficiency (B12 &lt; 200 mg\/mL) were enrolled in our study to evaluate the TCN2 and GIF polymorphisms. The control group (B12 &gt; 200 mg\/mL) included 100 individuals. Our results indicated a significant association between the homologous variant of the TCN2 gene (G776G) and vitamin B12 deficiency, and an intermediate phenotype in heterozygous individuals ( p &lt; 0.001, OR = 5.6, 95% CI = 2.95 to 10.63). The GIF gene, however, showed no correlation between the A68G variant and vitamin B12 deficiency ( p = 0.2). This study expounds the association of TCN2 polymorphism with cobalamin levels in a Jordanian population and highlights the necessity of further studies to elucidate the molecular basis and impact of TCN2 and GIF genes polymorphisms on vitamin B12 deficiency and associated disorders. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000536","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T12:05:36Z","timestamp":1550145936000},"page":"151-155","source":"Crossref","is-referenced-by-count":9,"title":["Homologous G776G Variant of <i>Transcobalamin-II<\/i> Gene is Linked to Vitamin B12 Deficiency"],"prefix":"10.31083","volume":"90","author":[{"given":"Khalid M.","family":"Al-Batayneh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazhar","family":"Salim Al Zoubi","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"},{"name":"Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahaa","family":"Al-Trad","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"},{"name":"Department of Food Science and Human Nutrition, College of Applied Sciences, A\u2019Sharqiyah University, Ibra, Oman"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesam","family":"Al Khateeb","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Yarmouk University, Irbid, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa A. 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