{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:05:25Z","timestamp":1723248325162},"reference-count":33,"publisher":"IMR Press","issue":"5-6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p> Abstract. CA 15-3 is a tumor-associated antigen and is overexpressed in breast tumors, and may also be high in some other non-cancerous conditions. The aim of this study was to investigate the effect of megaloblastic anemia due to vitamin B12 or folic acid deficiency on the levels of tumor markers. Five-year patient data were retrospectively analyzed. The associations between megaloblastic anemia due to vitamin B12 deficiency and CA 15-3, CA 125, CA 19-9, CEA, and AFP levels were analyzed. Furthermore, association between CA 15-3 level and megaloblastic anemia due to folic acid deficiency was evaluated. Median CA 15-3 level was 38.1\u00a0U\/mL in the group with megaloblastic anemia due to vitamin B12 deficiency(n\u00a0=\u00a015), 46.7\u00a0U\/mL in the group with megaloblastic anemia related to folic acid deficiency (n\u00a0=\u00a03), and 17.8\u00a0U\/mL in the normal group(n\u00a0=\u00a01724). CA 15-3 levels were significantly higher among patients with vitamin B12- and folic acid-associated megaloblastic anemia compared to the normal group (p\u00a0=\u00a00.001 and p\u00a0=\u00a00.005, respectively). Megaloblastic anemia due to vitamin B12 deficiency was not associated with any significant differences in CA 125, CA 19-9, CEA, or AFP levels compared to the normal group (p\u00a0=\u00a00.777, p\u00a0=\u00a00.327, p\u00a0=\u00a00.577, and p\u00a0=\u00a00.197, respectively). The numbers of anemic and normal subjects compared in these tests were 12 vs. 1501, 17 vs. 1827, 4 vs. 897, and 8 vs. 1041, respectively. In conclusion, megaloblastic anemia results in ineffective erythropoiesis, and increased levels of CA 15-3 may be associated with this issue. Clinicians should take this into account when evaluating for a pre-diagnosis of breast cancer. <\/jats:p>","DOI":"10.1024\/0300-9831\/a000555","type":"journal-article","created":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T13:03:19Z","timestamp":1552309399000},"page":"255-260","source":"Crossref","is-referenced-by-count":1,"title":["Vitamin B12 and folic acid associated megaloblastic anemia: Could it mislead the diagnosis of breast cancer?"],"prefix":"10.31083","volume":"89","author":[{"given":"Inanc","family":"Karakoyun","sequence":"first","affiliation":[{"name":"University of Health Sciences, Tepecik Training and Research Hospital, Department of Medical Biochemistry, Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Duman","sequence":"additional","affiliation":[{"name":"University of Health Sciences, Tepecik Training and Research Hospital, Department of Medical Biochemistry, Izmir, 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