{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:58:15Z","timestamp":1787065095289,"version":"build-2736575974"},"reference-count":49,"publisher":"IMR Press","issue":"3-4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal for Vitamin and Nutrition Research"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>\n                    Abstract. Iodine is essential for thyroid hormone synthesis. Under normal iodine supply, calculated physiological iodine concentration in the thyroid is approx. 9\u00a0mM. Either potassium iodide (KI) or potassium iodate (KIO\n                    <jats:sub>3<\/jats:sub>\n                    ) are used in iodine prophylaxis. KI is confirmed as absolutely safe. KIO\n                    <jats:sub>3<\/jats:sub>\n                    possesses chemical properties suggesting its potential toxicity. Melatonin (N-acetyl-5-methoxytryptamine) is an effective antioxidant and free radical scavenger. Study aims: to evaluate potential protective effects of melatonin against oxidative damage to membrane lipids (lipid peroxidation, LPO) induced by KI or KIO\n                    <jats:sub>3<\/jats:sub>\n                    in porcine thyroid. Homogenates of twenty four (24) thyroids were incubated in presence of either KI or KIO\n                    <jats:sub>3<\/jats:sub>\n                    without\/with melatonin (5\u00a0mM). As melatonin was not effective against KI-induced LPO, in the next step only KIO\n                    <jats:sub>3<\/jats:sub>\n                    was used. Homogenates were incubated in presence of KIO\n                    <jats:sub>3<\/jats:sub>\n                    (200; 100; 50; 25; 20; 15; 10; 7.5; 5.0; 2.5; 1.25\u00a0mM) without\/with melatonin or 17\u00df-estradiol. Five experiments were performed with different concentrations of melatonin (5.0; 2.5; 1.25; 1.0; 0.625\u00a0mM) and one with 17\u00df-estradiol (1.0\u00a0mM). Malondialdehyde\u00a0+\u00a04-hydroxyalkenals (MDA\u00a0+\u00a04-HDA) concentration (LPO index) was measured spectrophotometrically. KIO\n                    <jats:sub>3<\/jats:sub>\n                    increased LPO with the strongest damaging effect (MDA\u00a0+\u00a04-HDA level: \u22481.28\u00a0nmol\/mg protein, p\u00a0&lt;\u00a00.05) revealed at concentrations of around 15\u00a0mM, thus corresponding to physiological iodine concentrations in the thyroid. Melatonin reduced LPO (MDA\u00a0+\u00a04-HDA levels: from \u22480.97 to \u22480,76 and from \u22480,64 to \u22480,49\u00a0nmol\/mg protein, p\u00a0&lt;\u00a00.05) induced by KIO\n                    <jats:sub>3<\/jats:sub>\n                    at concentrations of 10\u00a0mM or 7.5\u00a0mM. Conclusion: Melatonin can reduce very strong oxidative damage to membrane lipids caused by KIO\n                    <jats:sub>3<\/jats:sub>\n                    used in doses resulting in physiological iodine concentrations in the thyroid.\n                  <\/jats:p>","DOI":"10.1024\/0300-9831\/a000628","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T02:30:30Z","timestamp":1576549830000},"page":"271-277","source":"Crossref","is-referenced-by-count":13,"title":["Melatonin reduces high levels of lipid peroxidation induced by \t\t\t\t\tpotassium iodate in porcine thyroid"],"prefix":"10.31083","volume":"91","author":[{"given":"Paulina","family":"Iwan","sequence":"first","affiliation":[{"name":"Department of Oncological Endocrinology, Medical \t\t\t\t\tUniversity of Lodz, Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Stepniak","sequence":"additional","affiliation":[{"name":"Department of Oncological 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